CAS: 1219-46-1; N6-Benzoyl-L-Lysine

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15647-47-9 78521-43-4 35340-63-7

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CAS号98-88-4 苯甲酰氯 | CAS号56-87-1 L-赖氨酸 | CAS号70326-37-3 3-苯甲酰噻唑烷-2-硫酮 | CAS号5107-18-6 DL-ω-苯甲酰赖氨酸 | CAS号109036-22-8 N6-benzoyl-N2-b... | CAS号32513-92-1 α,ε-二苯甲酰-DL-赖氨酸 | CAS号109454-36-6 N6-benzoyl-N2-c...

📜α,ε-二苯甲酰-Dl-赖氨酸 反应生成N-ε-苯甲酰基-L-赖氨酸
参考文献:Studies On Acylase Activity And Microorganisms. Xix Optical Resolution Of Threonine,Lysine,Tryptophan,And Methionine By Acylase Of Soil Bacteria
标题:Studies On Acylase Activity And Microorganisms. Xix Optical Resolution Of Threonine,Lysine,Tryptophan,And Methionine By Acylase Of Soil Bacteria
摘要:通过使用含有氨基酸n-酰基衍生物作为唯一碳源的合成培养基,分离出15株能够不对称水解n-苯甲酰-Dl-苏氨酸,2,6-二n-苯甲酰-Dl-赖氨酸,N-乙酰-Dl-赖氨酸,N-乙酰-Dl-色氨酸或n-乙酰-Dl-蛋氨酸的土壤细菌(见表i).N-苯甲酰-Dl-苏氨酸在kt 218,Kt 229和kt 83的酰化酶作用下不对称水解为l-苏氨酸,N-苯甲酰-D-苏氨酸和苯甲酸,而2,6-二n-苯甲酰-Dl-赖氨酸则在kt 218和kt 229的作用下水解为6-N-苯甲酰-L-赖氨酸,2,6-二n-苯甲酰-D-赖氨酸和苯甲酸.Kt 241和kt 224则分别将n-乙酰-Dl-色氨酸和n-乙酰-Dl-蛋氨酸不对称水解为l-色氨酸和n-乙酰-D-色氨酸以及l-蛋氨酸和n-乙酰-D-蛋氨酸.观测到n-乙酰-D-色氨酸和n-乙酰-D-蛋氨酸被若干株土壤细菌(如kt 229,Kt 83,Kt 222等)水解.值得注意的是,N-乙酰-L-蛋氨酸比n-乙酰-L-色氨酸更容易被kt 224或kt 218水解,而后者则更容易被kt 241水解.此外,L-蛋氨酸的n-乙酰衍生物比n-苯甲酰衍生物更容易被kt 224或kt 241水解,而后者则更容易被kt 218水解.
Doi:10.1248/cpb.10.1146

专利信息

专利号:US-4575503-A
优先权日:1983-02-10
标 题:3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
发明人：WATTHEY JEFFREY W H
权利人:CIBA GEIGY CORP
摘要:Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzaz epin-2-ones and functional derivatives are angiotensin converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.