CAS: 10141-72-7; 2-Methyltetrahydropyran (Iodixanol Impurity)

该化合物是一个环状环状物,由六人组成,含有碳和氧原子的环状结构,其特点是四氢环,有替代的甲基组,具有独特的特性,这种化合物一般没有色,有温和的香味.甲基氢以相对低的极分性闻名,在有机溶剂中溶解,但水溶解较少.其沸点和密度表明其分子重量和结构,影响其各种化学反应的行为.这种化合物经常在有机合成中使用,并作为一种溶剂,因为其稳定性和溶剂溶解一系列有机化合物的能力.此外,甲基四氟可以作为制药和化学研究中较复杂的分子合成的建筑块.安全数据表明,与许多有机溶液一样,应谨慎处理,以避免吸入或皮肤接触.

结构式图片

相似化合物

89791-47-9 1821720-33-5 33747-08-9

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合成工艺路线路线简述

    📜6-氯-2-己酮置于三正丁基氢锡体系中,60.0 °C,1399.99 Mpa 条件下,反应 24.0H,以90%的收率获得2-甲基四氢吡喃
    参考文献:Chimie有机金属盐的高级压强:氯代丙酮反应生成的三丁基酯
    标题:Chimie有机金属盐的高级压强:氯代丙酮反应生成的三丁基酯
    摘要:氢化三丁基锡与几种氯酮(3-氯-2-丁酮,4-氯-2-丁酮,5-氯-2-戊酮,6-氯-2-己酮和7-氯-2-庚酮的高压反应)导致形成氯代烷氧基锡或环醚.提出了一种从对羰基的亲核攻击开始的离子机理来解释反应产物的形成.
    Doi:10.1016/0022-328X(85)80067-X

    专利信息


    专利号:US-9126995-B2
    优先权日:2011-11-08
    标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
    发明人:TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU
    权利人:NISSAN CHEMICAL IND LTD
    摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.

    专利号:WO-03031376-A1
    优先权日:2001-10-12
    标 题 :Solid phase synthesis of substituted 1,5-benzodiazepine-2-one and 1,5-benzothiazepine-2-one
    发明人:MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F
    权利人:AVENTIS PHARMA INC; MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F
    摘要:A solid phase synthetic method for making substituted 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one. The method is useful for synthesis of large numbers of compounds through automated parallel synthesis or combinatorial library generation and is thus important to rapid discovery or new therapeutic agents containing the base structure of 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one.

    专利号:US-11912647-B2
    优先权日:2020-05-22
    标 题:Diversity-oriented synthesis of N,N,O-trisubstituted hydroxylamines from alcohols and amines by N—O bond formation
    发明人:CRICH DAVID; HETTIKANKANAMALAGE ASIRI; HILL JARVIS
    权利人:UNIV GEORGIA
    摘要:In one aspect, the disclosure relates to a method for the direct synthesis of complex N,N,O-trisubstituted hydroxylamines by N—O bond formation. In another aspect, the method can successfully be employed using a wide variety of commercially available alcohols and secondary amines and enables the construction of large fragment-based libraries of trisubstituted hydroxylamines for drug discovery purposes. Also disclosed are N,N,O-trisubstituted hydroxylamines having low basicity, high stability at ambient temperatures, and an inherent lack of reactivity towards acetylating and sulfonylating enzymes that confer mutagenicity on less-substituted hydroxylamines.

    专利号:US-7138526-B1
    优先权日:1999-06-15
    标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
    发明人:HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
    权利人:AVENTIS PHARMA INC
    摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

    专利号:US-7314960-B1
    优先权日:2006-09-28
    标 题:Catalytic synthesis of oxygenate from alcohol
    发明人:LIN SHENG-DIANN; HSIAO TING-CHOU
    权利人:UNIV YUAN ZE
    摘要:The present invention discloses a method for catalytic synthesis of oxygenate from alcohol. At first, a feeding material comprising at least one alcohol is provided. Next, a copper-containing catalyst is provided and the catalyst further comprises at least one metal element selected from the group consisting of the following: zinc, magnesium, and aluminum elements. Following that, a catalytic reaction of the feeding material over the copper-containing catalyst is carried out to synthesize at least one oxygenate.

    专利号:US-6127515-A
    优先权日:1997-11-18
    标 题:Functionalized resin for the synthesis of amides and peptides
    发明人:MANFRE FRANCO; VANASSE BENOIT J; LABAUDINIERE RICHARD F; MORTON GEORGE C
    权利人:AVENTIS PHARM PROD INC
    摘要:This invention is directed to a functionalized amino resin of formula ##STR1## wherein S is a solid support; R is H or alkyl; A is ##STR2## Y is OH or OCOR 1 ; and R 1 is aliphatic or aromatic which is useful for the solid phase synthesis of amides, peptides and hydroxamic acids.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Tsukamoto, M.; Kitamura, M., Science of Synthesis, (2008) 37, 81.
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