CAS: 937-30-4; 4-Ethylacetophenone

该化合物是属于氯酮类的有机化合物,其特征为碳基组(C=O)附属的苯基组和乙基组相对于乙酰组的副位置的乙基组,该化合物一般是无色的,可粉黄液,具有特殊的甜味和植物味,在水中可中中溶,但在乙醇和乙醇等有机溶剂中可溶性更大.该化合物主要用于香气工业和有机合成的中间体,其化学结构允许各种反应,包括氧化和减少,使其在合成应用中具有多种特性.此外,4欧元-乙型苯酮在正常条件下具有稳定性等特性,但应当谨慎处理,因为其具有潜在的刺激作用.与许多有机化合物一样,在处理或储存该物质时,应当采取适当的安全措施,以避免接触和确保安全使用.

英文名称4-Ethylacetophenone
中文名称对乙基苯乙酮
IUPAC名称1-(4-ethylphenyl)ethanone
其它别名4'-乙基苯乙酮; 4乙基苯乙酮; P-Ethylphenyl Methyl Ketone
CAS编号937-30-4
MFCD编号:MFCD00009262
EINECS号:213-326-5
FDA UNII编号:LSA7B53YDO
分子式:C10H12O
分子量:148.2
产品CID: 1977376
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
产品信息参考;;;;
InChIKey: NODGRWCMFMEGJH-UHFFFAOYSA-N
InChI=1S/C10H12O/c1-3-9-4-6-10(7-5-9)8(2)11/h4-7H,3H2,1-2H3…
计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数2.0

物理性质

熔点-20.6°C
沸点239.6°C at 760 mmHg
闪点90°C
密度1.0±0.1 g/cm3
PSA:17.07
LogP:2.4516
折射率1.508
蒸汽压0.0±0.5 mmHg at 25°C
溶解性Chloroform (Slightly), Ethyl Acetate (Slightly)
敏感性常温常压下稳定，避免氧化物接触
外观形态透明无色油状物
储存条件密封, 常温干燥保存
产品应用有机化工中间体.
性质描述无色或微黄色液体,密度0.993,熔点-20.6°C,沸点245°C,折射率1.5283-1.5303,闪点90°C

MSDS等安全信息

GHS符号GHS07
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
安全声明24/25
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

合成目标产物 4-Ethylacetophenone 主要起始原料 Ethylbenzene And Acetyl Chloride
40307-11-7 = 937-30-4
反应条件:1.1 Reagents: Water Catalysts: Indium Triflate Solvents: Sulfur Dioxide; -78 °C; 16 - 18 H,8 Bar,60 °C
标题:In(Iii) And Hf(Iv) Triflate-Catalyzed Hydration And Catalyst-Free Hydrohalogenation Of Aryl Acetylenes In Liquid Sulfur Dioxide
作者:Suta,Krista; Turks,Maris
参考文献:Acs Omega 日期:2018 卷标:3(12) 页码:18065-18077]

4433-63-0 + 99-90-1 = 937-30-4
反应条件:1.1 Catalysts: Di-μ-Chlorobis(η3-2-Propenyl)Dipalladium,Rel-1,1′,1′′,1′′′-[(1R,2R,3S,4S)-1,2,3,4-Cyclopentanetetrayltetrakis(Methylene)]... Solvents: Tetrahydrofuran; 10 Min,Rt1.2 Reagents: Potassium Carbonate Solvents: Xylene; 20 H,130 °C
标题:Tetraphosphine/palladium-Catalyzed Suzuki Cross-Coupling Reactions Of Aryl Halides With Alkylboronic Acids
作者:Kondolff,Isabelle; Doucet,Henri; Santelli,Maurice
参考文献:Tetrahedron 日期:2004 卷标:60(17) 页码:3813-3818]

40307-11-7 = 937-30-4
反应条件:1.1 Catalysts: Chloro[(Isocyano-Kc)Cyclohexane]Gold,Potassium Tetrakis(Pentafluorophenyl)Borate Solvents: Methanol,Water; 24 H,Rt
标题:Hydration Of Alkynes At Room Temperature Catalyzed By Gold(I) Isocyanide Compounds
作者:Xu,Yun; Hu,Xingbang; Shao,Jing; Yang,Guoqiang; Wu,Youting; Et Al
参考文献:Green Chemistry 日期:2015 卷标:17(1) 页码:532-537]

33967-18-9 = 937-30-4
反应条件:1.1 Reagents: Oxygen Catalysts: 9,10-Dicyanoanthracene Solvents: Acetonitrile; 60 Min,Rt
标题:9,10-Dicyanoanthracene Photosensitized Oxidation Of Aryl Alkanols: Evidence For An Electron Transfer Mechanism
作者:Lykakis,Ioannis N.; Lestakis,Stellios; Orfanopoulos,Michael
参考文献:Tetrahedron Letters 日期:2003 卷标:44(33) 页码:6247-6251]

40307-11-7 = 937-30-4
反应条件:1.1 Reagents: Water Catalysts: Silver Hexafluoroantimonate,1514905-15-7 Solvents: Methanol; 24 H,120 °C
标题:Au-Nhc@porous Organic Polymers: Synthetic Control And Its Catalytic Application In Alkyne Hydration Reactions
作者:Wang,Wenlong; Zheng,Anmin; Zhao,Peiqing; Xia,Chungu; Li,Fuwei
参考文献:Acs Catalysis 日期:2014 卷标:4(1) 页码:321-327]

40307-11-7 = 937-30-4
反应条件:1.1 Reagents: Silver Triflate Catalysts: 2378834-33-2 Solvents: Acetic Acid,Water; 10 H,100 °C
标题:The Synthesis Of Methyl Triazole-4-Carboxylate Gold(I) Complex And Application On Allene Synthesis And Alkyne Hydration
作者:Hu,Wenkang; Shan,Liang; Ma,Fudong; Zhang,Yilin; Yang,Yongchun; Et Al
参考文献:Inorganic Chemistry Communications 日期:2019 卷标:109]

13045-22-2 = 937-30-4
反应条件:1.1 Reagents: Oxygen Catalysts: Ethylene Glycol Diethyl Ether; Rt; 12 H,90 °C
标题:1,2-Diethoxyethane Catalyzed Oxidative Cleavage Of Gem-Disubstituted Aromatic Alkenes To Ketones Under Minimal Solvent Conditions
作者:Liu,Kai-Jian; Deng,Ji-Hui; Zeng,Tang-Yu; Chen,Xin-Jie; Huang,Ying; Et Al
参考文献:Chinese Chemical Letters 日期:2020 卷标:31(7) 页码:1868-1872]

10537-63-0 = 937-30-4
反应条件:1.1 Catalysts: Sodium Tert-Butoxide,Iridium,[9-[[bis(1,1-Dimethylethyl)Phosphino-Kp]Oxy]Benzo[h]Quinolin-10-Yl-Kc,K... Solvents: Ethanol; 30 Min,60 °C1.2 Reagents: Oxygen
标题:Transfer Hydrogenation Of Alkenes Using Ethanol Catalyzed By A Ncp Pincer Iridium Complex: Scope And Mechanism
作者:Wang,Yulei; Huang,Zhidao; Leng,Xuebing; Zhu,Huping; Liu,Guixia; Et Al
参考文献:Journal Of The American Chemical Society 日期:2018 卷标:140(12) 页码:4417-4429]

1009-61-6 = 937-30-4
反应条件:1.1 Reagents: Hydrogen,1-Butyl-3-Methylimidazolium Tetrafluoroborate Catalysts: Palladium; 20 H,30 Bar,120 °C
标题:Hydrogen-Bonding-Mediated Selective Hydrogenation Of Aromatic Ketones Over Pd/c In Ionic Liquids At Room Temperature
作者:Li,Ruipeng; Wang,Yuepeng; Zhao,Yanfei; Zhang,Fengtao; Zeng,Wei; Et Al
参考文献:Acs Sustainable Chemistry & Engineering 日期:2021 卷标:9(42) 页码:14216-14223]

40307-11-7 = 937-30-4
反应条件:1.1 Reagents: Water Catalysts: Sulfuric Acid Solvents: Acetonitrile; 20 Min,Rt
标题:Accelerated Metal-Free Hydration Of Alkynes Within Milliseconds In Microdroplets
作者:Zheng,Boyu; Jin,Xiaoxiao; Liu,Jinhua; Cheng,Heyong
参考文献:Acs Sustainable Chemistry & Engineering 日期:2021 卷标:9(12) 页码:4383-4390]

15519-23-0 = 937-30-4
反应条件:1.1 Reagents: Chlorotrimethylsilane,Sodium Iodide Solvents: Acetonitrile
标题:Extended Scope Of In Situ Iodotrimethylsilane Mediated Selective Reduction Of Benzylic Alcohols
作者:Cain,Gary A.; Holler,Edward R.
参考文献:Chemical Communications (Cambridge 日期:2001 卷标:(13) 页码:1168-1169]

40307-11-7 = 937-30-4
反应条件:1.1 Reagents: Water Catalysts: 2750707-54-9 (Salt With Hexafluoroantimonate); 20 H,60 °C
标题:Synthesis And Catalytic Properties Of Metal-N-Heterocyclic-Carbene-Decorated Covalent Organic Framework
作者:Li,Yue; Dong,Ying; Kan,Jing-Lan; Wu,Xiaowei; Dong,Yu-Bin
参考文献:Organic Letters 日期:2020 卷标:22(18) 页码:7363-7368]

40307-11-7 = 937-30-4
反应条件:1.1 Reagents: Water Catalysts: Molybdate(3-),Cobaltatehexa-μ3-Hydroxyhexa-μ-Oxododecaoxohexa-,Ammonium (1:3) Solvents: Formic Acid; 1 H,60 °C
标题:Hydration Of Alkynes To Ketones With An Efficient And Practical Polyoxomolybdate-Based Cobalt Catalyst
作者:Xie,Ya; Wang,Jingjing; Wang,Yunyun; Han,Sheng; Yu,Han
参考文献:Chemcatchem 日期:2021 卷标:13(23) 页码:4985-4989]

40307-11-7 = 937-30-4
反应条件:1.1 Reagents: Acetic Acid,P-Toluenesulfonic Acid Solvents: Dichloromethane; 3 H,50 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water
标题:A Combination System Of P-Toluenesulfonic Acid And Acetic Acid For The Hydration Of Alkynes
作者:Liu,Haixuan; Wei,Yunyang; Cai,Chun
参考文献:Synlett 日期:2016 卷标:27(16) 页码:2378-2383]

10537-63-0 = 937-30-4
反应条件:1.1 Reagents: 1,4-Dioxane Catalysts: Di-μ-Chlorobis[(1,2,5,6-η)-1,5-Cyclooctadiene]Diiridium,1,2-Bis(Dicyclohexylphosphino)Ethane; 5 Min,Rt1.2 10 H,130 °C
标题:Iridium-Catalyzed Alkene-Selective Transfer Hydrogenation With 1,4-Dioxane As Hydrogen Donor
作者:Zhang,Deliang; Iwai,Tomohiro; Sawamura,Masaya
参考文献:Organic Letters 日期:2019 卷标:21(15) 页码:5867-5872]

13329-40-3 = 937-30-4
反应条件:1.1 Reagents: Zinc,Sodium Iodide Catalysts: Dichloro[1,1′-(1,3-Propanediyl)Bis[1,1-Diphenylphosphine-Kp]]Nickel Solvents: Tetrahydrofuran; 24 H,Rt
标题:Nickel-Catalyzed Methylation Of Aryl Halides With Deuterated Methyl Iodide
作者:Hu,Lu; Liu,Xin; Liao,Xuebin
参考文献:Angewandte Chemie 日期:2016 卷标:55(33) 页码:9743-9747]

= 937-30-4
反应条件:1.1 Reagents: Potassium Bromide,Potassium Peroxymonosulfate Sulfate (2Khso5.Khso4.K2So4) Solvents: Acetonitrile,Water; 4 H,45 °C
标题:Oxidation Of Benzylic Methylenes To Ketones With Oxone-Kbr In Aqueous Acetonitrile Under Transition Metal Free Conditions
作者:Yin,Lixia; Wu,Jingjing; Xiao,Juan; Cao,Song
参考文献:Tetrahedron Letters 日期:2012 卷标:53(33) 页码:4418-4421]

40307-11-7 = 937-30-4
反应条件:1.1 Catalysts: [1,3-Bis[2,6-Bis(1-Methylethyl)Phenyl]-1,3-Dihydro-2H-Imidazol-2-Ylidene]Chlorog... Solvents: Methanol,Water; 6 H,110 °C
标题:Process For Preparation Of Ketone Compounds Through Alkyne Hydrolysis
参考文献:China]

40307-11-7 = 937-30-4
反应条件:1.1 Catalysts: [1,3-Bis[2,6-Bis(1-Methylethyl)Phenyl]-1,3-Dihydro-2H-Imidazol-2-Ylidene]Chlorog... Solvents: Methanol,Water; 6 H,110 °C; 110 °C -> Rt
标题:Regioselective Hydration Of Terminal Alkynes Catalyzed By A Neutral Gold(I) Complex [(Ipr)Aucl] And One-Pot Synthesis Of Optically Active Secondary Alcohols From Terminal Alkynes By The Combination Of [(Ipr)Aucl] And Cp*rHCL[(R,R)-Tsdpen]
作者:Li,Feng; Wang,Nana; Lu,Lei; Zhu,Guangjun
参考文献:Journal Of Organic Chemistry 日期:2015 卷标:80(7) 页码:3538-3546]

40307-11-7 = 937-30-4
反应条件:1.1 Catalysts: P-Toluenesulfonic Acid,Indium Triflate Solvents: 1,2-Dichloroethane,Water; 3.5 H,Reflux
标题:The Indium-Catalysed Hydration Of Alkynes Using Substoichiometric Amounts Of Ptsa As Additive
作者:Gao,Qi; Li,Shenyan; Pan,Yingming; Xu,Yanli; Wang,Hengshan
参考文献:Tetrahedron 日期:2013 卷标:69(19) 页码:3775-3781

4-乙炔基苯乙酮置于iron,氢气体系中,用均三甲苯作为反应溶剂,20.0 °C,1.0 Mpa 条件下,反应 20.0H,以90%的收率获得产物对乙基苯乙酮
参考文献:使用超小铁(0)纳米粒子作为不饱和cc键选择性加氢的催化剂.
标题:使用超小铁(0)纳米粒子作为不饱和cc键选择性加氢的催化剂.
摘要:报告了定义明确的超小铁(0)纳米粒子(nps)作为不饱和cc和c = X键选择性加氢催化剂的性能.通过{fe(n [si(ch3)3] 2)2} 2在二氢下的分解,合成了约2 Nm大小的单分散铁纳米颗粒.发现它们在温和条件下对各种烯烃和炔烃的氢化具有活性,对c = O键氢化的活性较弱.
DOI:10.1039/c3Cc00152K

海关参考信息

2902600000-乙苯
2912110000-甲醛
2912120000-乙醛
2912210000-苯甲醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-6413957-B1
优先权日:1998-04-21
标题:Methods of inhibiting cell proliferation using indeno [1,2-c]pyrazol-4-ones
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; YUE EDDY W
权利人:BRISTOL MYERS SUIBB PHARMA COM
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): n that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-2022145179-A1
优先权日:2020-11-12
标题 :Synthesis of aryl 1-(methoxymethyl) vinyl ketones and their use as inhibitors of mild steel corrosion
发明人：MAZUMDER MOHAMMAD ABU JAFAR; ALI SHAIKH ASROF; ODEWUNMI NURUDEEN; ALHARBI BADER; ALJEABAN NORAH; CHEN TAO; BALHARTH SALEM
权利人:SAUDI ARABIAN OIL CO; UNIV KING FAHD PET & MINERALS
摘要:Methods for preparing alkenylphenone corrosion inhibiting compositions may include providing an arylacetone and reacting the arylacetone with formaldehyde in the presence of a strong base catalyst. Corrosion inhibiting compositions may include an alkenylphenone, which may be prepared by a method including providing an arylacetone and reacting the arylacetone with formaldehyde in the presence of a strong base catalyst. Methods of inhibiting corrosion of a steel surface of an oilfield equipment component may include contacting the steel surface with an aqueous solution comprising a corrosion inhibitor. The corrosion inhibitor may include a composition containing an alkenylphenone prepared by reacting an arylacetone with formaldehyde in the presence of a strong base catalyst.

专利号:WO-2013067646-A1
优先权日:2011-11-12
标题:Process for the synthesis of beta-aminocarbonyls
发明人：BEAUCHEMIN ANDRE MARTIN; CLAVETTE CHRISTIAN; GAN WEI; MARKIEWICZ THOMAS; TODERIAN AMY BEVERLY
权利人:UNIV OTTAWA
摘要:The present application provides processes and intermediates useful in the production of Î²- aminocarbonyl- or Î²-aminothiocarbonyl-containing compounds. Provided herein is a process for synthesizing Î²-aminocarbonyl- or Î²-aminothiocarbonyl-containing compounds from an alkene and a hydrazone. Also provided herein is a process for synthesizing Î²-aminocarbonyl- or Î²-aminothiocarbonyl-containing compounds from an alkene and a hydrazine. The present application further provides intermediate aminoisocyanate and iminoisocyanate compounds, and methods for synthesizing the starting hydrazone and hydrazine compounds.

专利号:US-9603951-B2
优先权日:2010-02-08
标题 :Methods and apparatus for synthesizing imaging agents, and intermediates thereof
发明人：LAZEWATSKY JOEL; DEVINE MARYBETH
权利人:LANTHEUS MEDICAL IMAGING INC
摘要:The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including imaging agents comprising a radioisotope (e.g., 18 F). Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like. In some cases, methods for evaluating perfusion, including myocardial perfusion, are provided. Synthetic methods of the invention have also been incorporated into an automated synthesis unit to prepare and purify imaging agents that comprise a radioisotope. In some embodiments, the present invention provides a novel methods and systems comprising imaging agent 1, including methods of imaging in a subject comprising administering a composition comprising imaging agent 1 to a subject by injection, infusion, or any other known method, and imaging the area of the subject wherein the event of interest is located.

专利号:US-9744391-B2
优先权日:2009-11-26
标题:Use of metal-accumulating plants for implementing chemical reactions
发明人：GRISON CLAUDE; ESCARRE JOSE
权利人:CENTRE NAT RECH SCIENT; UNIV MONTPELLIER 2 SCIENCES ET TECHNIQUES
摘要:A method of implementing organic synthesis reactions uses a composition containing a metal catalyst originating from a calcined plant. The plants can be from the Brassicaceae, Sapotaceae and Convolvulaceae family, and the metal catalyst contains metal in the M(II) form such as zinc, nickel, manganese, lead, cadmium, calcium, magnesium or copper. Examples of the organic synthesis reactions include halogenations, electrophilic reactions, cycloadditions, transesterification reactions and coupling reactions, among others.

专利号:US-7250435-B2
优先权日:1999-10-20
标题:Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; VIDWANS ANUP P; YUE EDDY
权利人:BRISTOL MYERS SQUIBB PHARMA CO
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): n nthat are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G.n n This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

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合成参考文献

摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 173.
摘要:Rueda-Becerril, M.; Sammis, G. M., Science of Synthesis Knowledge Updates, (2017) 2, 219.
摘要:Llopis, Q.; Ayad, T.; Phansavath, P.; Ratovelomanana-Vidal, V., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2018) 2, 147.
摘要:Singh, F. V.; Wirth, T., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 54.
摘要:Ouyang, Y.; Shou, J.-Y.; Qing, F.-L., Science of Synthesis: Special Topics, (2022) 1, 251.

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CAS: 937-30-4; 4-Ethylacetophenone

物理性质

MSDS等安全信息

欧盟法规

上下游产品

合成工艺路线路线简述

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