CAS: 73205-13-7; (6α,8ξ,10ξ,11β,14ξ,16α,17α)-6,9-Difluoro-11-Hydroxy-16-Methyl-17-[(Methylsulfanyl)Carbonyl]-3-Oxoandrosta-1,4-Dien-17-Yl Propionat E

上下游产品

Propionic acid (6S,8S,9R,10S,11S,13S,14S,16R,17R)-17-(diethoxy-phosphoryloxycarbonyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester sodium thiomethoxide 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid 11β,17α,21-trihydroxy-6α,9α-difluoro-16β-methylpregna-1,4-diene-3,20-dione

二氟拉松置于tea,过碘酸,二异丙胺体系中,用 四氢呋喃,甲醇,水,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 35.0H,反应生成 氟替卡松丙酸酯usp杂质d
参考文献:Thiol Esters From Steroid 17.Beta.-Carboxylic Acids: Carboxylate Activation And Internal Participation By 17.Alpha.-Acylates
标题:Thiol Esters From Steroid 17.Beta.-Carboxylic Acids: Carboxylate Activation And Internal Participation By 17.Alpha.-Acylates
摘要:
DOI:10.1021/jo00362A028

专利信息

专利号:WO-9709067-A1
优先权日:1995-09-05
标 题 :Combination of 5-lipoxygenase and leukotriene synthesis inhibitors with glucocorticosteroids
发明人：BURCHARDT ELMAR-REINHOLD; MUELLER-PEDDINGHAUS REINER
权利人:BAYER AG; BURCHARDT ELMAR REINHOLD; MUELLER PEDDINGHAUS REINER
摘要:The combination is disclosed of 5-lipoxygenase inhibitors as direct action lipoxygenase inhibitors (LOI) or of leukotriene synthesis inhibitors (LSI) with glucocorticosteroids (GCS). This combination is suitable for treating and preventing various acute and chronic inflammatory processes, in particular of the respiratory tract, and may therefore be used as a medicament, in particular for treating asthma.

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.