CAS: 677-22-5; Tert-Butylmagnesium Chloride

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丙基三氯硅烷 反应生成 叔丁基氯化镁
参考文献:Method For Preparation Of Tertiary-Hydrocarbylsilyl Compounds
标题:Method For Preparation Of Tertiary-Hydrocarbylsilyl Compounds
摘要:一种用于制备三级烃基硅化合物的方法.该方法包括将含有二乙二醇二丁基醚和由式rmgx描述的格氏试剂混合物与由式r.Sup.1.Sub.A Six.Sub.4-A描述的硅化合物接触,其中r是一个包含四至约20个碳原子的三级烃基团,每个r.Sup.1是一个独立选择的取代或未取代的含有一至约20个碳原子的单价碳氢基团,每个x是一个独立选择的卤素原子,A是一个整数,值为零至三,在存在有效量的铜化合物催化剂的情况下.本发明提供了一种制备用于制药工业的立体位阻有机硅中间体的方法.

专利信息

专利号:WO-2022256490-A9
优先权日:2021-06-03
标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus
发明人：LOCKWOOD MARK
权利人:ANTIOS THERAPEUTICS INC
摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.

专利号:US-10392361-B2
优先权日:2016-01-21
标题:Process for the synthesis of intermediates of Nebivolol
发明人：BARTOLI SANDRA; MANNUCCI SERENA; GRISELLI ALESSIO; STEFANINI ALESSIO
权利人:MENARINI INT OPERATIONS LUXEMBOURG SA
摘要:The present invention relates to a novel process for the synthesis of the intermediate compounds constituted by chromanyl haloketones of formula III and 6-fluoro-2-(oxiran-2-yl)chromans of formula I. n The intermediates thus obtained can be used for the synthesis of Nebivolol.

专利号:US-4384998-A
优先权日:1981-03-30
标题:Synthesis of thienamycin from D-glucose
发明人：DURETTE PHILIPPE L
权利人:MERCK & CO INC
摘要:Disclosed is a chiral, total synthesis of thienamycin from D-glucose which proceeds via intermediates I, II and III to known aldehyde IV which is known to be useful in the total synthesis of thienamycin (V): ##STR1## wherein: R is lower alkyl having 1-6 carbon atoms or bi-valent alkyl having 2-6 carbon atoms which joins the two sulfur atoms; R 1 is lower alkyl or aralkyl, such as benzyl and the like; and R 2 is hydrogen or a removable protecting group, such as triorganosilyl wherein the organo groups are independently selected from lower alkyl, phenyl and phenylloweralkyl.

专利号:US-11603382-B2
优先权日:2015-12-11
标题 :Diastereoselective synthesis of phosphate derivatives
发明人：KOTALA MANI BUSHAN; DAMMALAPATI VENKATA LAKSHMI NARASIMHA RAO
权利人:NuCana plc
摘要:The present invention provides a method for the preparation of intermediates useful in the synthesis of gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate. It also provides a method of preparing gemcitabine-[phenyl-benzoxy-L-alaninyl)]-phosphate.

专利号:US-10669292-B2
优先权日:2014-05-05
标 题 :Synthesis of boronate salts and uses thereof
发明人：HECKER SCOTT; BOYER SERGE
权利人:REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.

专利号:US-5703223-A
优先权日:1994-09-02
标题 :Solid phase synthesis of oligonucleotides with stereospecific substituted phosphonate linkages by pentavalent grignard coupling
发明人：WICKSTROM ERIC; LE BEC CHRISTINE
权利人:UNIV JEFFERSON
摘要:The present invention provides a method for producing an oligonucleotide having stereospecific substituted phosphonate linkages by use of a pentavalent Grignard coupling reaction on a solid phase support. The method can be used for automated synthesis of oligonucleotides having sequential equatorial or axial stereospecific substituted phosphonate linkages.