CAS: 64191-13-5; (1S,2S)-2-Aminocyclopentanecarboxylic Acid

相似化合物

137170-89-9 143679-80-5 136315-70-3

上下游产品

CAS号611-10-9 环戊酮-2-羧酸乙酯 | CAS号359586-68-8 (1S,2S)-2-((S)-... | CAS号359586-66-6 (1S,2S)-2-[[(S)... | CAS号136237-71-3 (trans-(1S,2S)-... | CAS号143679-80-5 (1S,2S)-2-[(叔丁氧...

📜Tert-Butyl ((Trans)-2-Cyanocyclopentyl)Carbamate置于盐酸体系中,用85%的收率获得产物(1S,2S)-(-)-2-氨基-1-环戊烷羧酸
参考文献:新型硅烷取代的β-氨基酸的合成
标题:新型硅烷取代的β-氨基酸的合成
摘要:已经从简单的起始原料开发了非天然环状被硅烷取代的β-氨基酸的高效立体选择性合成方法.关键步骤是中间体氮丙啶与羧酸盐阴离子的聚砜合成子的亲核开环.官能团操纵和脱保护反应允许获得所需的反式β-氨基酸.
DOI:10.1016/s0040-4039(02)01085-7

专利信息

专利号:US-2023295613-A1
优先权日:2020-02-14
标 题:Long chain carbon and cyclic amino acids substrates for genetic code reprogramming
发明人：JEWETT MICHAEL C; LEE JOONGOO; MOORE JEFFREY S; SCHWARZ KEVIN J
权利人:UNIV NORTHWESTERN; UNIV ILLINOIS
摘要:Abstract: Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.

专利号:WO-2007091110-A1
优先权日:2006-02-09
标 题 :Enzymatic resolution process for the preparation of cycli-c beta-amino acid and ester enatiomers
发明人：FORRO ENIKO; FUELOEP FERENC
权利人:UNIV SZEGEDI; FORRO ENIKO; FUELOEP FERENC
摘要:The invention relates to a process for the preparation of cyclic β-amino acid and ester enantiomers of general formula (I) wherein R is hydrogen or optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl and heteroaryl, wherein each ring may optionally be condensed; A is alkylene or alkenylene, and one or more carbon atoms of each groups may optionally be replaced with one or more heteroatoms; Rl and R2 are hydrogen or halogen, =(O)n, optionally halogenated alkyl, alkylidene, alkoxy, optionally protected hydroxy, optionally protected amino, mono- or dialkylamino and optionally substituted phenyl, or Rl and R2 taken together with one or any two atoms of the ring to which they are attached, form a saturated, unsaturated or aromatic fused homo- or heterocyclic ring; n is 0, 1 or 2; * denotes a chiral carbon atom; and the salts thereof, comprising the steps of hydrolysing a mixture of cyclic β-amino ester enantiomers with a stereoselective hydrolytic enzyme, and separating the obtained acid enantiomer and the unreacted ester enantiomer. The invention provides an enzymatic resolution procedure for the preparation of enantiomers of both the cis- and trans-cyclic β-amino acids and esters useful for the synthesis ' of biologically active agents.

专利号:US-9168329-B2
优先权日:2006-09-01
标题 :Beta-peptides with antifungal activity
发明人：PALECEK SEAN P; GELLMAN SAMUEL H; POMERANTZ WILLIAM C; KARLSSON AMY J
权利人:PALECEK SEAN P; GELLMAN SAMUEL H; POMERANTZ WILLIAM C; KARLSSON AMY J; WISCONSIN ALUMNI RES FOUND
摘要:The present invention is directed to the design, synthesis and use of various β-peptides exhibiting antifungal activity. The β-peptides are relatively short in length, adopt globally amphiphilic conformations, and cause little lysis of human red blood cells at concentrations that kill Candida albicans , a common human fungal pathogen.