CAS: 613-45-6; 2,4-Dimethoxybenzaldehyde

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CAS号7314-44-5 2,4-二甲氧基苄醇 | CAS号31874-34-7 2,4-二甲氧基苯甲醛肟 | CAS号3030-94-2 2,4-dimethoxybe... | CAS号917-54-4 甲基锂 | CAS号114478-87-4 1-[bis(ethylsul... | CAS号151-10-0 间苯二甲醚 | CAS号332047-72-0 Tris(diformylam... | CAS号1001179-98-1 tert-butyl 2,4-... | CAS号93-61-8 N-甲基甲酰苯胺 | CAS号40243-84-3 2,4-Dimethoxy-1... | CAS号1063733-41-4 N-(2,4-二甲氧基苄基)-... | CAS号1099378-22-9 4-羟基-6,8-二甲氧基-2... | CAS号104202-36-0 2,4-dimethoxy-1... | CAS号496-73-1 2,4-二羟基甲苯 | CAS号4107-65-7 2,4-二甲氧基苯甲腈 | CAS号7314-44-5 2,4-二甲氧基苄醇 | CAS号1521-95-5 Benzamide,2,4-d... | CAS号91-52-1 2,4-二甲氧基苯甲酸 | CAS号13330-65-9 2,4-二甲氧基苯酚 | CAS号38064-90-3 2,4-二甲氧基甲苯

对二甲氧基苯甲醇置于sodium Borate,Dipotassium Peroxodisulfate,Sodium Hydride,叔丁醇体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 2,4-二甲氧基苯甲醛
参考文献:对羟基促进的甲氧基取代的1-芳基链烷醇自由基阳离子的oh断裂的结构影响:氧酸度的作用.
标题:对羟基促进的甲氧基取代的1-芳基链烷醇自由基阳离子的oh断裂的结构影响:氧酸度的作用.
摘要:动力学和产物研究,由oh诱导,H2O由一些二和三甲氧基取代的1-芳基烷醇(arch(oh)r * +)以及2-和3-(3,4-二甲氧基苯基)链烷醇已经通过使用脉冲-和γ-辐解技术进行.在1-芳基链烷醇体系中,自由基阳离子3,4-(meo)2C6H3Ch2-Oh * +的分解速率比其甲基醚的分解速率高两个数量级.这表明侧链oh基团在衰变过程中的关键作用(氧酸度).但是,与该α-非氘代对应物相比,该自由基阳离子具有相当大的氘动力学同位素效应(3.7).提出了一种机制,其中快速的oh去质子化导致自由基两性离子,然后进行速率确定的1,2-H移位,偶联至侧链至环的分子内电子转移(et)步骤.该概念也将重要的作用归因于该et的能量屏障,该能量屏障应取决于环中正电荷的稳定性,并因此取决于甲氧基的数量和位置.在相似的实验基础上,对于2,5-(meo)2C6H3Ch2Oh * +提出了与3,4-(meo)2C6H3Ch2Oh
DOI:10.1002/1521-3765(20010401)7:7<1408::Aid-Chem1408>3.0.Co;2-M

专利信息

专利号:US-5549974-A
优先权日:1994-06-23
标题:Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
发明人：HOLMES CHRISTOPHER P
权利人:AFFYMAX TECH NV
摘要:The invention provides an efficient and versatile method for the combinatorial synthesis and screening of libraries of 4-thiazolidinones, metathiazanones, and derivatives thereof. In order to expediently synthesize a combinatorial library of derivatives based upon these core structures, a general methodology for the solid phase synthesis of these derivatives is also provided. Arrays of thiazolidinones, metathiazanones, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antihistaminic, or antimicrobial activity or use in the treatment of inflammation, hypertension, renal failure, congestive heart failure, uremia and other conditions can be prepared using this method.

专利号:US-8742028-B2
优先权日:2009-05-06
标 题:Solid support for Fmoc-solid phase synthesis of peptide acids
发明人：SRIVASTAVA KRIPA S; DAVIS MATTHEW R
权利人:SRIVASTAVA KRIPA S; DAVIS MATTHEW R; MALLINCKRODT LLC
摘要:The present invention provides a solid support for Fmoc-solid phase synthesis of peptides. In particular, the solid supports of the invention may be utilized to produce peptide acids.

专利号:US-5124478-A
优先权日:1987-12-22
标 题:Acid-labile anchor groups for the synthesis of peptide amides by a solid-phase method
发明人：BREIPOHL GERHARD; KNOLLE JOCHEN; STUEBER WERNER
权利人:HOECHST AG
摘要:The invention relates to new compounds of the formula ##STR1## in which R 1 denotes (C 1 -C 8 )-alkyl, R 2 denotes an amino acid residue which is protected with a urethane protective group which can be eliminated with weak acid or base, or denotes an amino protective group which can be eliminated with weak acid or base, R 3 denotes hydrogen or (C 1 -C 4 )-alkyl, and Y 1 -Y 9 denote identical or different radicals hydrogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy or --O--(CH 2 ) n --COOH (with n=1 to 6), with one of these radicals being --O--(CH 2 ) n --COOH, or Y 1 , Y 2 and Y 5 -Y 9 denote identical or different radicals hydrogen, (C 1 -C 4 )-alkyl or (C 1 -C 4 )-alkoxy, Y 3 denotes hydrogen or (C 1 -C 8 )-alkoxy and Y 4 denotes --(CH 2 ) n --COOH or --NH--CO--(CH 2 ) n --COOH (with n=1 to 6). n Processes for the preparation thereof and the synthesis of peptide amides by a solid-phase method using these new compounds (spacers) are described.

专利号:US-8796454-B2
优先权日:2012-05-04
标 题 :Synthesis of [2.2.2]-diazabicyclic ring systems
发明人：SCHEERER JONATHAN R
权利人:COLLEGE WILLIAM & MARY
摘要:Herein we describe compositions and methods for the synthesis of [2.2.2]-diazabicyclic structures comprising a domino reaction sequence involving aldol condensation, alkene isomerization, and intramolecular hetero-Diels-Alder cycloaddition. Excellent diastereofacial control during the cycloaddition is enforced with a removable chiral phenyl aminal diketopiperazine substituent. The reaction sequence rapidly generates molecular complexity and is competent with both enolizable and non-enolizable aldehyde substrates. This method provides an efficient route to [2.2.2]-diazabicyclic structures, common to bioactive prenylated indole alkaloids such as the brevianamides and stephacidins.

专利号:US-5679773-A
优先权日:1995-01-17
标题 :Reagants and methods for immobilized polymer synthesis and display
发明人：HOLMES CHRISTOPHER P
权利人:AFFYMAX TECH NV
摘要:Compounds and methods for solid phase synthesis of organic molecules including peptides, oligonucleotides, benzodiazepines, beta -turn mimetics, and prostaglandins. The present invention provides new reagents in the form of linking groups and resins and substrates having attached linking groups which are useful in solid phase synthesis of high density arrays of organic molecules. The invention also provides methods which increase yields of various organic synthesis strategies.

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.