CAS: 474-07-7; (6As,11Br)-7,11B-Dihydroindeno[2,1-C]Chromene-3,6A,9,10(6H)-Tetraol

上下游产品

(3RS,4RS)-3-(3,4-dihydroxybenzyl)-3,4,7-trihydroxychroman (+/-)-episappanol (3RS,4SR)-3-(3,4-dihydroxybenzyl)-3,4,7-trihydroxychroman (+/-)-sappanol 2-(3-benzyloxy-phenoxymethyl)-indan-2,5,6-triol 1-diazo-3-(3-hydroxy-phenyl)-propan-2-oner,11bc)-7,11b-dihydro-indeno[2,1-c]chromene-3,6a,9,10-tetraol(+)-(6ar,11bc)-7,11b-dihydro-indeno[2,1-c]chromene-3,6a,9,10-tetraol (+/-)-Brasilin-tetraacetat brazilein (6aS,11bR)-3,9,10-Tris-benzyloxy-7,11b-dihydro-indeno[2,1-c]chromen-6a-ol

📜3-(3,4-Dimethoxy-Phenyl)-Propionyl Chloride置于aluminum (Iii) Chloride,Sodium Tetrahydroborate,四氧化锇,甲基磺酰胺,Ad-Mix β,4-甲基苯磺酸吡啶,三溴化硼,Sodium Hydride,二异丁基氢化铝,三苯基膦,Lithium Hydroxide,偶氮二甲酸二乙酯体系中,用 四氢呋喃,甲醇,二氯甲烷,水,甲苯,Paraffin Oil,叔丁醇 作为反应溶剂,化学反应 82.0H,反应生成 苏枋精
参考文献:Enantioselective Total Synthesis Of (+)-Brazilin,(−)-Brazilein And (+)-Brazilide A
标题:Enantioselective Total Synthesis Of (+)-Brazilin,(−)-Brazilein And (+)-Brazilide A
摘要:一种对映体选择性的合成策略已经开发出来,用于合成(+)-巴西林,(−)-巴西莱因和(+)-巴西酰a.通过路易斯酸介导的内酯化反应建立了巴西酰a的新型融合双内酯核心,并完成了(+)-巴西酰a的首次总体合成.
DOI:10.1039/c3Cc42385A

专利信息

专利号:US-2002165207-A1
优先权日:2001-05-02
标题 :Compositions and methods for the treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD
摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

专利号:US-7914823-B2
优先权日:2000-12-21
标题 :Method and composition for the topical treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD ALLEN
权利人:PROPHASE LABS INC
摘要:A method and composition for the treatment of diabetic neuropathy is disclosed. The composition comprises a cold compounded mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant formulated in a pharmaceutically acceptable carrier. It has been found that this combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In view of the consensus in the art that effective combinations of various active agents have not been demonstrated to be effective for the treatment of diabetic neuropathy, the present invention provides a surprising and unexpected effect. In addition, the topical compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the topical administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is topically administered to the areas of the body that have been adversely affected by the diabetic neuropathy on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms and at least some recovery of the damaged nerve tissues.

专利号:US-2005175556-A1
优先权日:2004-02-07
标题 :Skin Darkening (Sunless Tanning) Compositions Based on Enhancement of Melanin Synthesis by Tyrosinase Promoters
发明人：GUPTA SHYAM K
权利人:BIODERM RESEARCH
摘要:This invention discloses skin darkening (sunless tanning) compositions based on enhancement of melanin synthesis by tyrosinase enzyme by providing essential substrates for tyrosinase as well as the essential elements to activate the active-site of tyrosinase enzyme. These compositions thus also act as promoters of tyrosinase enzyme.

专利号:US-2023097824-A1
优先权日:2020-05-08
标 题:Semi-synthesis and use of racemic hematoxylin
发明人：DURRANT EDWARD E; HEINDL DIETER; HUBER FLORIAN MAURITIUS ERASUMU; KLEIN ERIC; KOSMEDER II JEROME W; VOSS EDGAR
权利人:VENTANA MED SYST INC; ROCHE DIAGNOSTICS OPERATIONS INC
摘要:A racemic hematoxylin formulation is disclosed that includes one or both of a stabilizer compound and an antioxidant. The disclosed composition exhibits sufficient stability to be utilized in an automated staining process. Methods of using and making the stabilized composition also are disclosed.

专利号:CN-110776488-B
优先权日:2019-12-04
标 题:Synthesis of (-)-Brazilin

专利号:CN-110776488-A
优先权日:2019-12-04
标 题 :Synthesis of (-)-Brazilin