CAS: 446-09-3; 2-Bromo-5-Fluoronitrobenzene

上下游产品

CAS号460-00-4 对氟溴苯 | CAS号364-78-3 4-氟-2-硝基苯胺 | CAS号351-83-7 对氟乙酰苯胺 | CAS号448-39-5 4'-氟-2'-硝基乙酰苯胺 | CAS号394-33-2 4-氟-2-硝基苯酚 | CAS号313337-34-7 4-氟-7-羧基吲哚 | CAS号387-43-9 4-氟吲哚 | CAS号292636-13-6 4-氟-1H-吲哚-7-胺 | CAS号255724-72-2 6-氟-2-苯基-1H-吲哚 | CAS号518990-79-9 2-甲砜基-5-氟硝基苯 | CAS号1003-99-2 2-溴-5-氟苯胺 | CAS号344790-96-1 5-溴-4-氟-1H-吲哚 | CAS号292636-09-0 7-溴-4-氟吲哚 | CAS号238418-75-2 4-(4-氟-2-硝基苯基)吗啉

1,4-二氟苯置于硫酸,氨,Potassium Nitrate,Sodium Nitrite体系中,用 水,二甲基亚砜 作为反应溶剂,化学反应生成 2-溴-5-氟硝基苯
参考文献:一种2-硝基-4-甲氧基苯甲酸的制备方法
标题:一种2-硝基-4-甲氧基苯甲酸的制备方法
摘要:本发明公开了一种2‑硝基‑4‑甲氧基苯甲酸的工业化制备方法.该2‑硝基‑4‑甲氧基苯甲酸的工业化制备方法,以对二氟苯为初始原料,经硝化,氨解,重氮上溴,氰化,甲氧基化以及水解六步反应合成2‑硝基‑4‑甲氧基苯甲酸.本过程得到的2‑硝基‑4‑甲氧基苯甲酸为白色粉末状固体,纯度98.5%,每步原料转化率分别达到100%,整个过程的总收率达到35.8%.

专利信息

专利号:US-8735586-B2
优先权日:2007-06-26
标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:US-2010261909-A1
优先权日:2007-06-26
标题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:WO-2009000413-A1
优先权日:2007-06-26
标题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:AU-2008267444-A1
优先权日:2007-06-26
标 题 :A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:EP-2173721-B1
优先权日:2007-06-26
标 题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:KR-20100023907-A
优先权日:2007-06-26
标题:Regioselective Copper Catalytic Synthesis of Benzimidazole and Azabenzimidazole