CAS: 268551-65-1; Tert-Butyl Carbamothioylcarbamate

该化合物是属于氨基甲酸酯类别的化学化合物,典型的是一种叔丁基乙基混合物,该混合物以其发育障碍闻名,附于氨基乙基乙基乙基甲酸酯,具有独特的特性,如各种化学环境中的稳定性和潜在反应性增强;该化合物可能具有氨基氨基甲酸酯的常见特性,包括作为核糖核糖核或电极在有机反应中发挥作用的能力;此外,该化合物还可用于农用化学,制药或合成有机化学的试剂,其溶性,熔点和其他物理特性取决于该物质的特定条件和纯度;处理和毒性信息时,应参考安全数据表,因为该类化合物的生物活动和环境影响可能大不相同.

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145013-05-4 598-52-7 621-83-0

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上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号892952-70-4 4-(氯甲基)噻唑-2-基氨基甲酸叔丁酯 | CAS号1001419-35-7 (4-(溴甲基)噻唑-2-基)...

合成工艺路线路线简述

    📜N,N'-二-Boc-硫脲置于sodium Hydride,三氟乙酸酐体系中,用 四氢呋喃,Mineral Oil 用作溶剂,化学反应 1.83H,反应生成N-Boc-硫脲
    参考文献:Guanidinium-Based Derivatives: Searching For New Kinase Inhibitors
    标题:Guanidinium-Based Derivatives: Searching For New Kinase Inhibitors
    摘要:Considering The Structural Similarities Between The Kinase Inhibitor Sorafenib And 4,4'-Bis-Guanidinium Derivatives Previously Prepared By Rozas And Co.,Which Display Interesting Cytotoxicity In Cancer Cells,We Have Studied Whether This Activity Could Result From Kinase Inhibition. Five New Families Have Been Prepared Consisting Of Unsubstituted And Aryl-Substituted 3,4'-Bis-Guanidiniums,3,4'-Bis-2-Aminoimidazolinium And 3-Acetamide-4'-(4-Chloro-3-Trifluoromethylphenyl)Guanidinium Derivatives. Cytotoxicity (Measuring The Ic50 Values) And Apoptosis Studies In Human Hl-60 Promyelocytic Leukemia Cells Were Carried Out For These Compounds. Additionally,Their Potential Inhibitory Effect Was Explored On A Panel Of Kinases Known To Be Involved In Apoptotic Pathways. The Previously Prepared Cytotoxic 4,4'-Bis-Guanidiniums Did Not Inhibit Any Of These Kinases; However,Some Of The Novel 3,4'-Substituted Derivatives Showed A High Percentage Inhibition Of Raf-1/mek-1,For Which The Potential Mode Of Binding Was Evaluated By Docking Studies. The Interesting Antitumour Properties Showed By These Compounds Open Up New Exciting Lines Of Investigation For Kinase Inhibitors As Anticancer Agents And Also Highlights The Relevance Of The Guanidinium Moiety For Protein Kinase Inhibitors Chemical Design. (C) 2014 Elsevier Masson Sas. All Rights Reserved.
    Doi:10.1016/j.Ejmech.2014.05.025

    海关参考信息

    专利信息


    专利号:CN-1819997-A
    优先权日:2003-07-08
    标题 :Synthesis of tri-N-alkylated 1,4,7, 10-tetraazacyclododecanes

    专利号:CN-100418957-C
    优先权日:2003-07-08
    标 题:Synthesis of Tri-N-Alkylated 1,4,7,10-tetraazacyclododecane

    专利号:CN-110156641-B
    优先权日:2019-07-03
    标 题 :Synthesis method of substituted guanidine

    专利号:CN-110407720-A
    优先权日:2019-08-20
    标 题 :A kind of synthesis method of iodine catalyzed thiourea desulfurization to prepare substituted guanidine

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Koutentis, P. A.; Ioannidou, H. A., Science of Synthesis Knowledge Updates, (2010) 1, 276.
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