CAS: 2559761-14-5; 4-((2S,5R)-4-Acryloyl-2,5-Dimethylpiperazin-1-yl)-7-(2-Amino-6-Fluorophenyl)-1-(4,6-Dicyclopropylpyrimidin-5-yl)-6-Fluoropyrido[2,3-D]Pyrimidin-2(1H)-One

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    主要参考文献


    1: Shi Z, Weng J, Niu H, Yang H, Liu R, Weng Y, Zhu Q, Zhang Y, Tao L, Wang Z, Huh SJ, Jiang Y, Mei H, Dai X, Zhang L, Wang Y. D-1553: A novel KRASG12C inhibitor with potent and selective cellular and in vivo antitumor activity. Cancer Sci. 2023 Jul;114(7):2951-2960. doi: 10.1111/cas.15829. Epub 2023 May 9.
    2: Li Z, Song Z, Zhao Y, Wang P, Jiang L, Gong Y, Zhou J, Jian H, Dong X, Zhuang W, Cang S, Yang N, Fang J, Shi J, Lu J, Ma R, Wu P, Zhang Y, Song M, Xu CW, Shi Z, Zhang L, Wang Y, Wang X, Zhang Y, Lu S. D-1553 (Garsorasib), a Potent and Selective Inhibitor of KRASG12C in Patients With NSCLC: Phase 1 Study Results. J Thorac Oncol. 2023 Jul;18(7):940-951. doi: 10.1016/j.jtho.2023.03.015. Epub 2023 Mar 21.

    合成参考文献


    参考文献:10.1016/j.ejmech.2025.117643
    摘要:Zhao X, Yuan L, Gong Z, Li M, Yuan Y, Geng J. New drugs approved by the NMPA in 2024: Synthesis and clinical applications. European Journal of Medicinal Chemistry. 2025 Jul;291():117643. doi: 10.1016/j.ejmech.2025.117643.
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