CAS: 19686-73-8; 1-Bromopropan-2-Ol

该化合物是一种多用途有机化合物,可应用有机合成.它具有二次酒精功能,可进行多种变异.它的高纯度和受控溴化使其具有合成各种有机化合物的理想性.它的低毒性和储存稳定性是额外的优势,有助于其在研究和工业环境中的效用.

结构式图片

相似化合物

16088-60-1 96-21-9 2482-57-7

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

propene diethyl ether 1,2-dibromoethyl acetate methylmagnesium bromide fluoro-acetic acid-(β-bromo-isopropyl ester) 1-(methylthio)propan-2-ol stearic acid-(2-hydroxy-propyl ester) propylene glycol distearate

合成工艺路线路线简述

    溴丙酮置于lithium Aluminium Tetrahydride体系中,用15%的收率获得溶剂紫36
    参考文献:Catalytic Asymmetric Cyclization Of Some Bromohydrins With Chiral Cobalt Complex
    标题:Catalytic Asymmetric Cyclization Of Some Bromohydrins With Chiral Cobalt Complex
    摘要:在存在光学活性的钴(Salen)型复杂物的情况下,研究了多种溴醇与碱的非对称环化反应.获得了光学纯度适中的光学活性环氧烷.赤霉-3-溴-2-丁醇和反霉-3-溴-2-丁醇进行了类似的环化,分别仅获得了反-2,3-二甲基环氧烷和顺-2,3-二甲基环氧烷,这表明溴醇的环化过程通过完全的sn2型反应进行.
    Doi:10.1246/bcsj.61.603

    海关参考信息

    专利信息


    专利号:US-12441721-B2
    优先权日:2020-07-21
    标 题 :Synthesis of heterocyclic compounds from carboxamide and carboxamide derivatives with haloalkanols
    发明人:KARPOORMATH RAJSHEKHAR; SAYYAD NISAR
    权利人:UNIV OF KWAZULU NATAL
    摘要:The invention provides for methods for the synthesis of various compounds through reaction of carboxamide, or carboxamide derivatives, with various substituted or unsubstituted haloalkanols in a one-step, single vessel, reaction mechanism. Preferably, but not exclusively, the reaction proceeds in the absence of any solvents, catalyst, base, or any further reagents.

    专利号:US-4226778-A
    优先权日:1978-04-14
    标 题:Process for the manufacture of alkylene carbonates
    发明人:VENTURELLO CARLO; D ALOISIO RINO
    权利人:MONTEDISON SPA
    摘要:A new process is disclosed for the synthesis of alkylene carbonates having from 2 to 4 carbon atoms in the chain, starting from a corresponding halohydrin having the formula: wherein Ra, Rb, Rc and Rd are independently hydrogen or alkyl, aryl, alkylaryl or arylalkyl radicals and where X is a halogen, characterized in that said halohydrin is reacted with a bicarbonate of a quaternary -onium compound, where '-onium' means ammonium, phosphonium, arsonium or stibonium, preferably using an organic solvent as diluent and operating in the presence of carbon dioxide.

    专利号:US-2012328569-A1
    优先权日:2010-03-02
    标题:Inhibitors of hepatitis c virus ns5b polymerase
    发明人:MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO; NARJES FRANK; HABERMANN JOERG; KOCH UWE; LIU SHILAN
    权利人:MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO; NARJES FRANK; HABERMANN JOERG; KOCH UWE; LIU SHILAN
    摘要:Disclosed are compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

    专利号:US-5637757-A
    优先权日:1995-04-11
    标 题 :One-pot synthesis of ring-brominated benzoate compounds
    发明人:HILL JOHN E; FAVSTRITSKY NICOLAI A; MAMUZIC RASTKO I; BHATTACHARYA BHABATOSH
    权利人:GREAT LAKES CHEMICAL CORP
    摘要:A method of preparing tetrabromobenzoate compounds from tetrabromophthalic anhydride by reacting tetrabromophthalic anhydride with alcohol in the presence of a decarboxylation catalyst. The reaction may be carried out in an excess of alcohol, or with a near stoichiometric amount of alcohol by performing the reaction in an inert solvent.

    专利号:US-9834536-B2
    优先权日:2013-04-23
    标题:Method for producing catalyst for cyclic carbonate synthesis
    发明人:TAKAHASHI TOSHIKAZU; YASUDA HIROYUKI; SAKAKURA TOSHIYASU; YAMAMOTO SHOUJI; NANIKI TAKASHI; FURUKAWA TAKURO
    权利人:AIST; MARUZEN PETROCHEM CO LTD
    摘要:A method for producing a heterogeneous catalyst for use of synthesizing cyclic carbonates by reacting an epoxide and carbon dioxide in the presence of the catalyst. A method for making a catalyst that includes forming a catalyst precursor then reacting the catalyst precursor with a tertiary phosphine.

    专利号:US-2023295139-A1
    优先权日:2020-07-21
    标题 :Synthesis of heterocyclic compounds from carboxamide and carboxamide derivatives with haloalkanols
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    主要参考文献

    [参考文献]: Karla M S Gonalves, Et Al. Conformational Analysis Of 1-Chloro- And 1-Bromo-2-Propanol. J Phys Chem A. 2013 Oct 24;117(42):10980-4.

    合成参考文献


    摘要:2024 Emergency Response Guidebook,
    摘要:National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
    摘要:Quick CPC - Forsberg K, Mansdorf SZ. Quick Selection Guide to Chemical Protective Clothing, 5th Ed. Hoboken, NJ: Wiley-Interscience, 2007.
    摘要:Rück-Braun, K.; Freysoldt, T., Science of Synthesis, (2007) 35, 505.
    摘要:Virieux, D.; Volle, J.-N.; Pirat, J.-L., Science of Synthesis, (2009) 42, 514.
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