专利号:US-6020447-A 优先权日:1996-03-29 标 题 :Sonichemical synthesis of silicon carbide precursors and methods for preparation thereof 发明人:SEYFERTH DIETMAR; SUGIMOTO TOSHIYA; CZUBAROW PAWEL 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:A process is provided that involves reductive coupling of polysilane precursors to form polysilane in the presence of ultrasonification. The resulting precursors, upon pyrolysis, lead to improved SiC ceramic product. Ultrasonification can be used to produce oligosilanes from precursors thereof, or polysilanes from monomers, dimers, trimers, or oligomers. Precursors can include Si:C in a ratio of about 1:1, and the invention allows formation of SiC having a Si:C ratio of about 1:1.
专利号:US-6372938-B1 优先权日:2001-05-21 标题:Synthesis of 4-phenylbutyric acid 发明人:BURZYNSKI STANISLAW R; MUSIAL LESZEK 权利人:BURZYNSKI STANISLAW R 摘要:A method of synthesizing compounds of Formula I:by reacting aromatic compounds with butyrolactone, followed by neutralization with base. The reaction can be conducted in the presence of a catalyst. Preferred catalysts are Lewis acids. A preferred product of Formula I is 4-phenylbutyric acid, which is obtained by the reaction of benzene with butyrolactone in the presence of aluminum chloride, followed by neutralization with base.
专利号:US-2008227846-A1 优先权日:2007-03-13 标 题:Methods of treating juvenile type 1 diabetes mellitus 发明人:SINGH INDERJIT; KEY LYNDON 权利人:MUSC FOUND FOR RES DEV; UNIV SOUTH CAROLINA 摘要:The present disclosure describes methods for treating or preventing Type 1 diabetes mellitus in juveniles, particularly in juveniles newly diagnosed with Type 1 diabetes. This prevention or treatment of Type 1 diabetes is achieved by administering one or more therapeutic agents to a juvenile in need, wherein the therapeutic agent is, for example, a competitive inhibitor of mevalonate synthesis, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, or an inducer of AMP protein kinase (AMPK) activity. In certain embodiments, juveniles with Type 1 diabetes are treated with an HMG-CoA reductase inhibitor such as a statin, thereby decreasing the destruction of islet cells, or maintaining endogenous insulin production, in the juvenile.
专利号:US-2008275104-A1 优先权日:1997-11-25 标 题 :Methods of treating juvenile type 1 diabetes mellitus 发明人:SINGH INDERJIT; KEY LYNDON 权利人:MUSC FOUND FOR RES DEV 摘要:The present disclosure describes methods for treating Type 1 diabetes mellitus in juveniles. This treatment of Type 1 diabetes is achieved by administering one or more therapeutic agents to a juvenile in need, wherein the therapeutic agent is, for example, a competitive inhibitor of mevalonate synthesis, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, or an inducer of AMP protein kinase (AMPK) activity. In certain embodiments, juveniles with Type 1 diabetes are treated with an HMG-CoA reductase inhibitor such as a statin.
专利号:IT-201800009372-A1 优先权日:2018-10-11 标题:PROCESS FOR THE SYNTHESIS OF CARGLUMIC ACID
专利号:EP-3686190-A1 优先权日:2013-07-11 标 题 :Synthesis of therapeutically active compounds
1: Glycerol phenylbutyrate (Ravicti) for urea cycle disorders. Med Lett Drugs Ther. 2014 Aug 18;56(1449):77-8. Review. Review. doi: 10.2165/11591280-000000000-00000. Review. 4: Bugaut M, Fourcade S, Gondcaille C, Gueugnon F, Depreter M, Roels F, Netik A, Berger J, Martin P, Pineau T, Cadepond F, El Etr M, Savary S. Pharmacological induction of redundant genes for a therapy of X-ALD: phenylbutyrate and other compounds. Adv Exp Med Biol. 2003;544:281-91. Review. Review. Review. Review. Review. Review.
合成参考文献
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