专利号:US-7105695-B2 优先权日:2001-12-21 标题 :Synthesis of combretastatin A-2 prodrugs 发明人:PETTIT GEORGE R; MOSER BRYAN R 权利人:UNIV ARIZONA STATE 摘要:The original synthesis of combretastatin A-2 (1a) was modified to provide an efficient scale-up procedure for obtaining this antineoplastic stilbene. Subsequent conversion to a useful prodrug was accomplished by phosphorylation employing in situ formation of dibenzylchlorophosphite followed by cleavage of the benzyl ester protective groups with bromotrimethylsilane to afford phosphoric acid intermediate 11. The latter was immediately treated with sodium methoxide to complete a practical route to the disodium phosphate prodrug (2a). The phosphoric acid precursor (11) of phosphate 2a was employed in a parallel series of reactions to produce a selection of metal and ammonium cation prodrug candidates. Each of the phosphate salts (2a–q) was evaluated with respect to relative solubility behavior, cancer cell growth inhibition, and antimicrobial activity.
专利号:US-5905136-A 优先权日:1994-12-21 标 题 :Polycondensation catalyzers for the synthesis of polyethylene terephtalate 发明人:PO RICCARDO; PELOSINI LUIGI 权利人:MONTEFIBRE SPA; INCA INTERNATIONAL SPA 摘要:PCT No. PCT/EP95/04883 Sec. 371 Date Jun. 19, 1997 Sec. 102(e) Date Jun. 19, 1997 PCT Filed Dec. 6, 1995 PCT Pub. No. WO96/19518 PCT Pub. Date Jun. 27, 1996The subject is a class of catalyzers to be used in the stage of polycondensation of the synthesis of poly(ethylene terephtalate), consisting of metal and non-metal derivatives in composition with sulfonic acids mixed with titanium compounds so that the final polymer contains a sulfur quantity of 5-60 ppm and a quantity of metals between 2 and 100 ppm.
专利号:US-5644019-A 优先权日:1995-06-01 标题 :High activity catalytic system for the synthesis of poly(ethylene terephthalate) 发明人:PO' RICCARDO; PELOSINI LUIGI; OCCHIELLO ERNESTO; FIOCCA LUISA 权利人:ENICHEM SPA 摘要:In the present invention, a class of catalysts is described, to be used in the polycondensation stage in the synthesis of poly(ethylene terephthalate), constituted by a composition of metal derivatives in quantity so that the content of these in the final polymer is below 130 ppm.
专利号:US-5296208-A 优先权日:1992-08-07 标 题 :Molecular sieve synthesis 发明人:LESCH DAVID A 权利人:UOP INC 摘要:In the hydrothermal synthesis of crystalline microporous molecular sieves from a reaction system containing an organic templating agent, it is found that removal of at least some of the organic reagent prior to the time the formation of crystalline product is complete results in an increased yield of the product. The removal of the organic reagent disrupts the equilibrium that is normally established in the reaction system at the selected crystallization temperature between product formation and product dissolution and shifts the reaction toward the formation of additional product before a new equilibrium can form.
专利号:US-2024173708-A1 优先权日:2022-11-14 标题 :Molecular Sieve CIT-17, Its Synthesis and Use 发明人:ALSHAFEI FAISAL H; DAVIS MARK E 权利人:CALIFORNIA INST OF TECHN 摘要:The present disclosure is directed to novel silicoaluminophosphate (SAPO)-based material with an SAT framework structure (topology type) (SAPO-SAT) that is substantially free of a non-SAPO-SAT phase, as well as the synthesis and use of that SAPO-SAT.
专利号:US-7557096-B2 优先权日:1998-01-09 标题 :Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof 发明人:PETTIT GEORGE R; RHODES MONTE R 权利人:UNIV ARIZONA 摘要:Combretastatin A-4 has been previously selected for pre-clinical development as antineoplastic agent. However, it is essentially insoluble in water. New water soluble derivatives of combretastatin A-4 and its qualified analogs have been discovered and synthesized through a multistage process using other derivatives of combretastatin A-4 as intermediates. These water soluble derivatives are herein denominated as “Combretastatin A-4 Prodrugsâ€?.
[参考文献]: Krisztian Nemeth, Et Al. Synthesis And Investigation Of Sio 2-Mgo Coated Mwcnts And Their Potential Application. Sci Rep. 2019 Oct 22;9(1):15113. [参考文献]: Andrey G Malyutin, Et Al. Coat Protein-Dependent Behavior Of Poly(Ethylene Glycol) Tails In Iron Oxide Core Virus-Like Nanoparticles. Acs Appl Mater Interfaces. 2015 Jun 10;7(22):12089-98. [参考文献]: Catarina M S S Neves#, Et Al. Effect Of Salts On The Solubility Of Ionic Liquids In Water: Experimental And Electrolyte Perturbed-Chain Statistical Associating Fluid Theory. Phys Chem Chem Phys. 2015 Dec 21;17(47):32044-32052. [参考文献]: Coilín Boland#, Et Al. Cell-Free Expression And In Meso Crystallisation Of An Integral Membrane Kinase For Structure Determination. Cell Mol Life Sci. 2014 Dec;71(24):4895-4910. [参考文献]: Hieu Bui, Et Al. Programmable Periodicity Of Quantum Dot Arrays With Dna Origami Nanotubes. Nano Lett. 2010 Sep 8;10(9):3367-72.