CAS: 14691-88-4; 4-Amino-2,2,6,6-Tetramethylpiperidine 1-Oxyl

相似化合物

14691-89-5 2564-83-2 7031-93-8

上下游产品

4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE 4-oxo-2,2,6,6-tetramethylpiperidin-oxyl 4-azido-2,2,6,6-tetramethyl-1-piperidinyloxy radical N,N:N',N'-di-1,2-ethanediyl-N''-(1-oxy-2,2,6,6-tetramethyl-4-piperidyl)phosphorothioic triamide 2,2,6,6-tetramethylpiperidine-1-oxyl-4-succinamic acid bis(p-nitrophenyl) 1-oxy-2,2,6,6-tetramethyl-4-piperidinyl phosphoramidate triethylamine hydr°Chloride

四甲基哌啶酮置于sodium Tungstate (Vi) Dihydrate,乙二胺四乙酸,Ammonium Acetate,双氧水,Sodium Cyanoborohydride体系中,用 甲醇,水 用作溶剂,化学反应 96.0H,反应生成4-氨基-Tempo
参考文献:带有自旋标记抑制剂dcc和archazolid的v‐atpase的epr研究:质子易位亚基c的相互作用动力学
标题:带有自旋标记抑制剂dcc和archazolid的v‐atpase的epr研究:质子易位亚基c的相互作用动力学
摘要:液泡型h +-Atpases(v-Atpases)作为高度有希望的抗癌药物靶标最近受到关注,因此详细的结构分析和抑制剂相互作用的研究是非常重要的研究目标.通过两种新颖的方法共价结合(2,2,6,6-四甲基哌啶-1)来自旋分离烟草酵母(saccharomyces Cerevisiae)液泡中的烟草天蛾manduca Sexta的v-Atpase全酶和v-Atpase的自旋标记.N,N'的‐yl)氧基(tempo)衍生物-二环己基碳二亚胺(dcc)与活性位点中的必需谷氨酸残基以及强效抑制剂archazolid(一种来自粘菌的天然产物)的自由基类似物的非共价相互作用.通过电子顺磁共振(epr)光谱研究和双电子-电子共振(deer)测量对这两种配合物进行了详细评估,从而揭示了对抑制剂结合模式,动力学和化学计量以及对中央功能亚基c的了解.这些具有医学重要性的异质多聚体质子转运蛋白.这项研究还证明了
Doi:10.1002/cmdc.201500500

专利信息

专利号:WO-2013182636-A1
优先权日:2012-06-07
标 题 :Synthesis of a viral protease inhibitor
发明人：ALLEGRINI PIETRO; BRUNOLDI ENRICO; ATTOLINO EMANUELE
权利人:DIPHARMA FRANCIS SRL
摘要:Disclosed is a process for the preparation of telaprevir of formula (I) or a salt thereof, comprising the oxidation reaction of a compound of formula (II) or a salt thereof, (II) wherein said oxidation is conducted in a solvent in the presence of a supported oxidising agent.

专利号:US-7205385-B2
优先权日:2004-11-12
标 题:Polymerization method for the synthesis of polypeptide imaging agents
发明人：GRIMMOND BRIAN JAMES; MOASSER BAHRAM; AMARATUNGA MOHAN MARK
权利人:GEN ELECTRIC
摘要:A method for synthesizing extended poly(amino acids) conjugated to imaging agents, such as DTPA, is disclosed. The amino acid is initially conjugated to the imaging agent at the monomer stage, followed by formation of the corresponding N-carboxyanhydride. The method utilizes catalyzed ring opening polymerization of the N-carboxyanhydride of the amino acid-imaging agent monomer allowing the formation of a poly(amino acid) backbone having 100% imaging agent conjugation if desired. However, the present method also permits the degree of conjugation to be controlled by copolymerizing the N-carboxyanhydride of the amino acid-imaging agent monomer with one or more unconjugated monomers, i.e. N-carboxyanhydrides of the same or of other amino acids. Various imaging agents may be employed, and new hybrid random, block, and mixed copolymers may be prepared.

专利号:WO-2024256666-A1
优先权日:2023-06-16
标 题:Production of synthesis gas by partial oxidation of a hydrocarbon stream containing plastic liquefaction oil
发明人：ADAM CINDY; CHOFFAT ALEXANDRINE; MINOUX DELPHINE; VAN LOOK EMMANUEL; BRETON CHRISTOPHE
权利人:TOTALENERGIES ONETECH
摘要:The invention relates to a process for the production of synthesis gas by partial oxidation from a hydrocarbon stream containing plastic liquefaction oil, comprising: a) providing a composition stabilized against premature polymerization comprising: 1) a hydrocarbon stream containing at least 2 wt% of plastic liquefaction oil which is containing contaminants, the remaining part of said hydrocarbon stream being a diluent, 2) at least one additive capable to reduce gums formation or buildup, 3) optionally at least one additive which is a dispersant agent, b) an optional purification step to trap silicon and/or metals and/or phosphorous and/or halogenates over at least one trap to obtain a purified composition, c) gasifying by partial oxidation the stabilized composition provided in step (a), or the purified composition provided in step (b), in a partial oxidation gasification unit to produce synthesis gas comprising at least dihydrogen, carbon monoxide, and carbon dioxide.

专利号:US-2002055124-A1
优先权日:1998-09-23
标题:Soluble support for organic synthesis
发明人：JANDA KIM D; GRAVERT DENNIS J
权利人:SCRIPPS RESEARCH INST
摘要:Polymer supports for liquid-phase organic synthesis (LPOS) are employed in a process for transferring a chemical intermediate between immiscilbe solvents. These compounds are produced with an expanded range of solubility range in a variety of solvent systems. A sequence of normal and “livingâ€? free radical polymerizations are employed to generate a library of block copolymers possessing either block or graft architecture with initiators 100, 200 and 3 - 4 and a diverse set of vinyl monomers 5 - 9 . Novel bifunctional initiators are employed that have functional groups that independently produce free radical polymerizations to produce the block copolymers. Preferred functional groups include diazene (—Nâ•?N—) and 2,2,6,6-tetramethylpiperidinyl-1-oxy (TEMPO) moieties tethered by ester or ether linkages.

专利号:WO-2020120582-A1
优先权日:2018-12-11
标题:Chromenic phytocannabinoids, their synthesis and use in treatment or prevention of disease
发明人：MUÑOZ BLANCO EDUARDO; APPENDINO GIOVANNI; UNCITI BROCETA JUAN DIEGO
权利人:EMERALD HEALTH BIOTECHNOLOGY ESPANA S L U
摘要:The present invention relates to a compound of the formula (I) or a solvate or co-crystal thereof (I) wherein: - R is selected from the group consisting of: a C1-C6 alkyl, a C2-C8 alkenyl moiety, a C4-C12 dienyl or a C6-C18 trienyl moiety; - R1 is a C1-C6 alkyl moiety; - R2 is selected from the group consisting of: H and a C1-C6 alkyl moiety; - R3 is selected from the group consisting of: H and a C1-C6 alkyl moiety; - R4 is selected from the group consisting of: H, a C1-C6 alkyl moiety and a benzyl moiety. The present invention also relates to a process for producing said compound of the formula (I), or a solvate or co-crystal thereof, as well as a pharmaceutical composition comprising said compound of the formula (I), or a solvate or co-crystal thereof and at least one excipient. The present invention also relates to a compound of the formula (I), or a solvate or co-crystal thereof, for use in the treatment or prevention of a disease or condition.

专利号:US-2007160574-A1
优先权日:2000-04-12
标题 :Design of CXC chemokine analogs for the treatment of human diseases
发明人：MERZOUK AHMED; SALARI HASSAN
权利人:MERZOUK AHMED; SALARI HASSAN
摘要:The present invention generally relates to the design, preparation, derivation, and use of mimetics of CXC chemokines (CXCL1-CXCL17) in the prevention, treatment, and ameliorization of a wide variety of diseases and disorders. Generally speaking, this invention is directed to the design, synthesis, and use of chemokine analogs which bind to CXC chemokine receptors CXCR1-CXCR7, such that the analogs can be designed to affect the activity of the receptor, either as an agonist or an antagonist. The analogs can be useful for treating a wide variety of diseases and disorders, and can also serve as an adjunct to the treatment of a variety of diseases and disorders.