CAS: 13189-98-5; (R)-2-Amino-3-((3-Hydroxypropyl)Thio)Propanoic Acid

上下游产品

S-Formylethylcysteine
L-半胱氨酸 L-Cysteine 52-90-4
D-半胱氨酸 Cysteine 921-01-7

S-Formylethylcysteine置于sodium Tetrahydroborate体系中,化学反应 2.0H,以34.5 G的收率获得福多司坦
参考文献:一种福多司坦的合成方法
标题:一种福多司坦的合成方法
摘要:本发明涉及一种福多司坦的合成方法,属生物医药产业领域.以l‑半胱氨酸与丙烯醛为原料,在酸性水溶液中,进行michael加成反应,之后加入硼氢化钠还原,一锅法合成福多司坦,重结晶得到高纯度的福多司坦.本制备方法反应条件温和可控,产品收率95%,液相纯度99.8%.

专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-2015158809-A9
优先权日:2013-02-26
标 题 :Method of making 1-(acyloxy)-alkyl carbamate compounds
发明人：WANG HUAN; LIU PENG; DAI QUNYING; YIN HAO; RAILLARD STEPHEN P
权利人:XENOPORT INC
摘要:Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.

专利号:WO-2009094569-A2
优先权日:2008-01-25
标 题:Method for the enzymatic kinetic resolution of acyloxyalkyl thiocarbonates used for the synthesis of acyloxyalkyl carbamates

专利号:US-2005222431-A1
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof

专利号:US-7227028-B2
优先权日:2003-12-30
标题 :Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof

专利号:US-2007244331-A1
优先权日:2003-12-30
标 题 :Synthesis of Acyloxyalkyl Carbamate Prodrugs and Intermediates Thereof