CAS: 129741-57-7; (2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-Dihydroxy-6-(Hydroxymethyl)-5-(((2S,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-2-yl)Oxy)Methyl)-3,4,5-Trihydroxytetrahydro-2H-Pyran-2-Yl (1R,3As,5Ar,5Br,7Ar,8R,9S,11Ar,11Br,13Ar,13Br)-9-(((2S,3R,4S,5S)-4,5-Dihydroxy-3-(((2S,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-2-yl)Oxy)-8-(Hydroxymethyl)-5A,5B,8,11A-Tetramethyl-1-(Prop-1-En-2-yl)Icosahydro-3Ah-Cyclopenta[a]Chrysene-3A-Carboxylate
该化合物是一种天然化合物,被归类为三叶杆素沙邦素,主要来自阿内莫酮植物,以其药性著称;该化合物呈现出一种复杂的分子结构,其特征是带有多颗糖糖的类固醇脊椎,有助于其生物活动;Anemoside B4因其潜在的药理效应,包括抗炎,抗氧化剂和免疫性肺炎特性而引起注意;该化合物经常被研究其在传统医学中的作用及其在现代治疗中的潜在应用;该化合物的溶性与稳定性可能因所使用的溶剂而不同,而不同,溶剂是提取和配方的一个重要考虑因素;此外,Anemoside B4的安全性和功效是正在进行的研究的主题,因为科学家们正在探索其在治疗各种健康状况方面的行动机制和潜在好处.
- 英文名称(2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-Dihydroxy-6-(Hydroxymethyl)-5-(((2S,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-2-yl)Oxy)Methyl)-3,4,5-Trihydroxytetrahydro-2H-Pyran-2-Yl (1R,3As,5Ar,5Br,7Ar,8R,9S,11Ar,11Br,13Ar,13Br)-9-(((2S,3R,4S,5S)-4,5-Dihydroxy-3-(((2S,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-2-yl)Oxy)-8-(Hydroxymethyl)-5A,5B,8,11A-Tetramethyl-1-(Prop-1-En-2-yl)Icosahydro-3Ah-Cyclopenta[a]Chrysene-3A-Carboxylate
- 中文名称白头翁皂苷 B4
- IUPAC名称(2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl (1R,3aS,5aR,5bR,7aR,8R,9S,11aR,11bR,13aR,13bR)-9-(((2S,3R,4S,5S)-4,5-dihydroxy-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-8-(hydroxymethyl)-5a,5b,8,11a-tetramethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylate
- 其它别名Pulchinenoside B4 ; Chinensioside A ; Pulsatilla Saponin B4 ; Anemoside B4
- CAS编号129741-57-7
- MFCD编号:MFCD13195300
- FDA UNII编号:JP928BN4LE
- 分子式:C59H96O26分子量:1221.39
- 产品CID: 456990
- 产品分类生物化工 → 植物提取物
物理性质
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海关参考信息
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2905122000-异丙醇
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主要参考文献
1: Bay S, Digwal CS, Rodilla Martín AM, Sharma S, Stanisavljevic A, Rodina A, Attaran A, Roychowdhury T, Parikh K, Toth E, Panchal P, Rosiek E, Pasala C, Arancio O, Fraser PE, Alldred MJ, Prado MAM, Ginsberg SD, Chiosis G. Synthesis and Characterization of Click Chemical Probes for Single-Cell Resolution Detection of Epichaperomes in Neurodegenerative Disorders. Biomedicines. 2024 Jun 4;12(6):1252. doi: 10.3390/biomedicines12061252.
2: Mohammed OA, Youssef ME, Doghish AS, Hamad RS, Abdel-Reheim MA, Alghamdi M, Alamri MMS, Alfaifi J, Adam MIE, Alharthi MH, Alhalafi AH, Bahashwan E, Rezigalla AA, BinAfif DF, Abdel-Ghany S, Attia MA, Elmorsy EA, Al-Noshokaty TM, Fikry H, Saleh LA, Saber S. A novel combination therapy targets sonic hedgehog signaling by the dual inhibition of HMG-CoA reductase and HSP90 in rats with non-alcoholic steatohepatitis. Eur J Pharm Sci. 2024 Jul 1;198:106792. doi: 10.1016/j.ejps.2024.106792. Epub 2024 May 5. 46(4):2946-2960. doi: 10.3390/cimb46040184.
4: Vogt M, Dienstbier N, Schliehe-Diecks J, Scharov K, Tu JW, Gebing P, Hogenkamp J, Bilen BS, Furlan S, Picard D, Remke M, Yasin L, Bickel D, Kalia M, Iacoangeli A, Lenz T, Stühler K, Pandyra AA, Hauer J, Fischer U, Wagener R, Borkhardt A, Bhatia S. Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells. Cell Death Dis. 2023 Dec 6;14(12):799. doi: 10.1038/s41419-023-06337-3.
合成参考文献
参考文献:10.1248/cpb.56.1138
摘要:Tsunoda Y, Okawa M, Kinjo J, Ikeda T, Nohara T. Studies on the constituents of Gueldenstaedtia multiflora. Chem Pharm Bull (Tokyo). 2008 Aug;56(8):1138–42. doi: 10.1248/cpb.56.1138.
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