CAS: 1195-59-1; 2,6-Pyridinedimethanol

该化合物是一种多用途的七环化合物,在环的2和6个位置上有两个水氧化甲基组.这种双功能结构使乙醇成为有机合成中有价值的中间体,特别是在准备离子,聚合物和制药化合物方面.它的硬性丙烯酸核心增强了稳定性,而氢氧化硫组则为进一步发挥功能提供了反应场所,如酯化或化.该化合物还有助于协调化学,成为金属离子的铬化剂.其高纯度和定义明确的再活性使其适合于催化,材料科学和药化学研究的应用.

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相似化合物

15658-60-3 499-83-2 5431-44-7

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CAS号5453-67-8 2,6-吡啶二甲酸二甲酯 | CAS号15658-60-3 2,6-吡啶二羧酸二乙酯 | CAS号862379-50-8 pyridine-2,6-di... | CAS号499-83-2 2,6-吡啶二羧酸 | CAS号5431-44-7 2,6-吡啶二甲醛 | CAS号108-48-5 2,6-二甲基吡啶 | CAS号1073-23-0 2,6-二甲基吡啶 N-氧化物 | CAS号13287-64-4 (6-甲基吡啶-2-基)甲基乙酸酯 | CAS号122637-39-2 6-乙酰基-2-吡啶羧酸 | CAS号5431-44-7 2,6-吡啶二甲醛 | CAS号39621-11-9 6-(羟基甲基)吡啶甲醛 | CAS号40054-01-1 6-(溴甲基)-2-吡啶甲醇 | CAS号7703-74-4 2,6-双(溴甲基)吡啶 | CAS号50501-31-0 (6-(氨基甲基)吡啶-2-基)甲醇 | CAS号209215-55-4 2,6-吡啶二乙酸 | CAS号1882-26-4 吡卡酯 | CAS号65053-12-5 2,6-Bis-hydroxy... | CAS号2893-33-6 2,6-吡啶二甲腈 | CAS号3099-28-3 2,6-双(氯甲基)吡啶

合成工艺路线路线简述

  • 合成目标产物 2,6-Pyridinedimethanol 主要起始原料 Dimethyl 2,6-Pyridinedicarboxylate
  • (文献来源)合成步骤主要原料 Dimethyl 2,6-Pyridinedicarboxylate
2,6-二甲基吡啶置于aluminum (III) Chloride,Sodium Tetrahydroborate,Potassium Permanganate,硫酸,水体系中,用 四氢呋喃,甲苯 用作溶剂,化学反应 0.58H,反应生成2,6-吡啶二甲醇
参考文献:一种2,6-二氯甲基吡啶盐酸盐的制备方法
标题:一种2,6-二氯甲基吡啶盐酸盐的制备方法
摘要:本发明属于有机合成领域,具体涉及一种2,6‑二氯甲基吡啶盐酸盐的制备方法,该方法包括以下步骤:(1)以2,6‑二甲基吡啶为原料,制备2,6‑吡啶二甲酸;(2)2,6‑吡啶二甲酸与甲醇在酸性条件下生成2,6‑吡啶二甲酸二甲酯;(3)2,6‑吡啶二甲酸二甲酯还原为2,6‑吡啶二甲醇;(4)2,6‑吡啶二甲醇与氯化亚砜反应得到目的产物2,6‑二氯甲基吡啶盐酸盐.采用本发明的有益效果是:本发明采用常用的含有吡啶环的化工原料进行乙酰基化反应,反应步骤少,成本低,毒性小,收率高,适于工业化生产.

海关参考信息

专利信息


专利号:US-11945838-B2
优先权日:2018-12-20
标 题:Method for synthesis of protein amphiphiles
发明人:BRITTO Sandanaraj Selvaraj; REDDY Mullapudi Mohan
权利人:INDIAN INSTITUTE OF SCIENCE EDUCATION AND RES
摘要:The present invention discloses a novel cost effective method for synthesis of protein/peptide amphiphiles irrespective of functional and structural classification of proteins useful in designing a vaccine candidate from antigenic protein. The protein modification of the present invention is universal and hence any protein/peptide can be converted into amphiphilic proteins/peptides.

专利号:US-2025250302-A1
优先权日:2024-02-05
标题:Synthesis of self-assembling artificial proteins utilizing a host-guest system and uses thereof
发明人:SANDANARAJ BRITTO S; KHYADE ASHWINI RAJENDRA; HATI KSHITISH CHANDRA
权利人:INDIAN INSTITUTE OF SCIENCE EDUCATION AND RES PUNE IISER PUNE
摘要:The invention relates to an efficient method for synthesizing self-assembling artificial proteins (SAPs) utilizing a catalytic host-guest system. The process involves encapsulating hydrophobic probes with cyclodextrin, performing site-specific protein bioconjugation, and employing a second catalysis cycle for enhanced labeling. SAPs produced through this method are versatile and find applications in therapeutic delivery and diagnostics. The process is simplified, scalable, cost-effective, and environmentally sustainable, addressing the challenges of traditional SAP synthesis. By offering improved yield, functionality, and structural integrity, this invention advances the potential of SAPs in medical and industrial fields.

专利号:US-9045381-B2
优先权日:2010-10-19
标 题:Ruthenium complexes and their uses in processes for formation and/or hydrogenation of esters, amides and derivatives thereof
发明人:MILSTEIN DAVID; BALARAMAN EKAMBARAM; GUNANATHAN CHIDAMBARAM; GNANAPRAKASAM BOOPATHY; ZHANG JING
权利人:MILSTEIN DAVID; BALARAMAN EKAMBARAM; GUNANATHAN CHIDAMBARAM; GNANAPRAKASAM BOOPATHY; ZHANG JING; YEDA RES & DEV
摘要:The present invention relates to novel Ruthenium catalysts and related borohydride complexes, and the use of such catalysts, inter alia, for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e., synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines. The present invention further relates to the novel uses of certain pyridine Ruthenium catalysts.

专利号:WO-2024104923-A1
优先权日:2022-11-16
标 题 :Manganese- and iron-containing catalysts comprising an imine ligand for the synthesis of polyurethanes
发明人:SCHAUB THOMAS; JOOST MAXIMILIAN; SALA OLIVER; RUDDIGKEIT MIRIAM; POELTL JOERG; BOKERN STEFAN; KAMM MARINA; HASHMI A STEPHEN K; OCANSEY EDWARD
权利人:BASF SE
摘要:The present invention relates to a process for the production of a polyurethane comprising the application of a manganese- and iron-containing catalysts wherein the catalyst comprises at least on imine ligand, which is defined by the general formula (I). The catalysts comprise a salicylaldehyde based imine according to the general formula (II) as an imine ligand. The present invention is further directed to a polyol component comprising a catalyst according to the invention, and a polyurethane produced according to such a process.

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:US-2020199175-A1
优先权日:2018-12-20
标题 :Method for synthesis of protein amphiphiles
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主要参考文献

[参考文献]: Taketo Taguchi, Et Al. Unusual Fe9 And Fe18 Structural Types From The Use Of 2,6-Pyridinedimethanol In Fe(Iii) Cluster Chemistry. Dalton Trans. 2010 Oct 14;39(38):9131-9.

合成参考文献


参考文献:10.1021/ic0346329
摘要:Jude H, Krause Bauer JA, Connick WB. Tuning the electronic structures of platinum(II) complexes with a cyclometalating aryldiamine ligand. Inorg Chem. 2004 Jan 26;43(2):725–33. doi: 10.1021/ic0346329.
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