CAS: 10385-36-1; 1-Bromo-2,3,4-Trimethoxybenzene

相似化合物

20129-11-7 2675-79-8 18111-34-7

上下游产品

2-bromo-pyridine 1,2,3-trimethoxybenzene phosphorus pentabromide bromine 1,2,3,4-tetramethoxybenzene t-Butyl-2.3.4-trimethoxyphenylhydroxylamin 1,2,3-trimethoxy-4-methylbenzene 1-piperidine-3,4,5-trimethoxybenzene

📜1,2,3-三甲氧基苯置于kaolin,Sodium Chlorite,Manganese(III) Acetylacetonate,Sodium Bromide体系中,用 二氯甲烷 用作溶剂,化学反应 2.0H,以97%的收率获得2,3,4-(三甲氧基)溴苯
参考文献:高岭土辅助芳香氯化和溴化
标题:高岭土辅助芳香氯化和溴化
摘要:潮湿的高岭土用 Naclo2 和 Mn(Acac) 催化 C6H5Or(r=c1-C8 烷基,丁基,烯丙基,环己基,苄基)到 4-Xc6H4Or(分别为 X=cl 和 Br)的区域选择性和高产氯化和溴化在温和和中性条件下,分别在不存在和存在 Nabr 的情况下在 Ch2Cl2 中反应生成3.
Doi:10.1039/a804043E

专利信息

专利号:US-6355826-B1
优先权日:1997-09-17
标题:Synthesis of stable nitrile oxide compounds
发明人：PARKER DANE KENTON
权利人:GOODYEAR TIRE & RUBBER
摘要:This invention discloses a process for the synthesis of stable aryl nitrile oxides which comprises the sequential steps of (1) halomethylating a halomethyl group onto a substituted aromatic compounds wherein said halomethyl group is halomethylated onto a position that is ortho to at least one of the substituent groups on the substituted aromatic compound; (2) converting the ortho halomethylated-substituted aromatic compound into an ortho-substituted aromatic aldehyde by reacting the ortho halomethylated-substituted aromatic compound with a salt selected from the group consisting of sodium 2-nitropropane and potassium 2-nitropropane in a lower alcohol solvent; (3) converting the ortho-substituted aromatic aldehyde into an ortho-substituted aromatic; and (4) converting the ortho-substituted aromatic oxime into the ortho-substituted aryl nitrile oxide by reacting the ortho-substituted aromatic oxime with an aqueous sodium hypochlorite solution.

专利号:CA-2245780-A1
优先权日:1997-09-17
标 题 :Synthesis of stable nitrile oxide compounds

专利号:US-6403814-B1
优先权日:1998-10-16
标 题 :Method for synthesizing diaryl-substituted heterocyclic compounds, including tetrahydrofurans
发明人：RAO ALLA VENKATA RAMA; CHORGHADE MUKUND S; ISLAM AMIN UL; RAO VEMURI VENKATA KIRAN; PRASAD ANEGONDI SREENIVASA; RAO BATCHU VENKATESWARA; REDDY RANGA; REDDY LALATA KRISHNAKANTH; SHAILAJA KOTAKONDA; GURJAR MUKUND KESHAO; MHASKAR SUNIL VYANKATESH
权利人:MILLENNIUM PHARM INC
摘要:A method is provided for synthesizing diaryl-substituted heterocyclic compounds, particularly 2,5-diaryl-substituted tetrahydrofurans and tetrahydrothiophenes. Methods for synthesizing starting materials and intermediates are provided as well. An important application of the invention is in the synthesis of CMI-392, (±)trans-2-[5-N'-methyl-N'-hydroxyureidyl-methyl)3-methoxy-4-p-chlorophenylthioethoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran, a highly effective agent in treating inflammatory and immune disorders. The invention also encompasses novel compounds useful as starting materials and intermediates in the synthetic processes disclosed.

专利号:KR-19990029856-A
优先权日:1997-09-17
标 题 :Synthesis of Stable Nitrile Oxide Compounds

专利号:US-2002128491-A1
优先权日:1999-10-15
标题 :Method for synthesizing diaryl-substituted heterocyclic compounds, including tetrahydrofurans
发明人：RAO ALLA VENKATA RAMA; CHORGHADE MUKUND S; ISLAM AMIN UL; RAO VEMURI VENKATA KIRAN; PRASAD ANEGONDI SREENIVASA; RAO BATCHU VENKATESWARA; REDDY RANGA; REDDY LALATA KRISHNAKANTH; SHAILAJA KOTAKONDA; GURJAR MUKUND KESHAO; MHASKAR SUNIL VYANKATESH
摘要:A method is provided for synthesizing diaryl-substituted heterocyclic compounds, particularly 2,5-diaryl-substituted tetrahydrofurans and tetrahydrothiophenes. Methods for synthesizing starting materials and intermediates are provided as well. An important application of the invention is in the synthesis of CMI-392, (±) trans-2-[5-(N′-methyl-N′-hydroxyureidyl-methyl)-3-methoxy-4-p-chlorophenylthioethoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran, a highly effective agent in treating inflammatory and immune disorders. The invention also encompasses novel compounds useful as starting materials and intermediates in the synthetic processes disclosed.

专利号:EP-0903338-A2
优先权日:1997-09-17
标 题:Synthesis of stable nitrile oxide compounds