CAS: 956-89-8; 3,3-Diphenyldihydrofuran-2(3H)-One

该化合物是一种循环酯(内酯),其特点是处于α位置的两个苯组,具有结构僵硬性和芳香性,该化合物是有机合成的多功能中间体,特别是在制备药品,农用化学品和精细化学品方面;其内酯功能可产生环状开关反应,而二苯替代可增强核分裂性或电益性变异的稳定性和影响反应性;该化合物的晶体质性质有利于净化和处理;其定义明确的结构有助于研究反应机制中的消毒和电子效应;其应用包括用作手淫辅助剂的前体或用于药用化学的脚手架,用于生物活性分子的发育.

结构式图片

相似化合物

1131-15-3 14702-32-0 6836-98-2

物理性质

MSDS等安全信息

上下游产品

2,5-呋喃二酮,二氢-3,3-二苯基- α,α-Diphenylsuccinic Acid Anhydride 14702-32-0
双苯溴丁酸 4-Bromo-2,2-Diphenylbutyric Acid 37742-98-6
4-Diethylamino-2,2-Diphenyl-Butyric Acid 6309-42-8
2,2-二苯基-4-哌啶子基-丁酸 2,2-Diphenyl-4-Piperidino-Butyric Acid 102597-35-3
2,2-二苯基丁烷-1,4-二醇 2,2-Diphenyl-1,4-Butanediol 69177-61-3
2,2-二苯乙酸乙酯 Ethyl Diphenylacetate 3468-99-3

合成工艺路线路线简述

  • 93022-10-7 = 956-89-8 + 119-61-9 + 86-73-7 + 101109-90-4
    反应条件:1.1 Solvents: Benzene; 600 °C
    标题:Thermal Rearrangement Of Phenyl-Substituted Ketene Ethylene Acetals
    作者:Oda,Mitsunori; Morimoto,Kazuo; Thanh,Nguyen Chung; Ohta,Reina; Kuroda,Shigeyasu
    参考文献:Heterocycles 日期:2003 卷标:60(7) 页码:1673-1680]

    = 956-89-8 [标题:Reaction Conditions
    标题:Palladium-Catalyzed Oxidative Cyclization Of 1,4- And 1,5-Diols In 1,2-Dichloroethane
    作者:Ait-Mohand,Samia; Muzart,Jacques
    参考文献:Journal Of Molecular Catalysis A: Chemical 日期:1998 卷标:129(2-3) 页码:135-139]

    69177-61-3 = 956-89-8 + 67390-35-6
    反应条件:1.1 Reagents: Pyridinium Chlorochromate Solvents: Dichloromethane
    标题:The Oxidation Of Alcohols By Modified Oxochromium(Vi)-Amine Reagents
    作者:Luzzio,Frederick A.
    参考文献:Organic Reactions (Hoboken 日期:1998 卷标:53]

    525-06-4 + 96690-03-8 = 956-89-8 + 93022-10-7 [标题:Reaction Conditions
    标题:Control Of Product In The Reaction Of Tributyltin ω-Haloalkoxide (Bu3Sno(Ch2)Nx) With Diphenylketene
    作者:Shibata,Ikuya; Baba,Akio; Matsuda,Haruo
    参考文献:Bulletin Of The Chemical Society Of Japan 日期:1986 卷标:59(12) 页码:4000-2]

    14702-32-0 = 956-89-8 [标题:Reaction Conditions
    标题:Changing Regioselectivity Patterns In Metal Hydride Reductions Of Unsymmetrically Substituted Cyclic Anhydrides
    作者:Kayser,Margaret M.; Salvador,Judith; Morand,Peter
    参考文献:Canadian Journal Of Chemistry 日期:1983 卷标:61(3) 页码:439-41]

    = 956-89-8 [标题:Reaction Conditions
    标题:Synthesis Of The New Antidiarrheal Drug-Loperamide
    作者:Chu,Chi-Ya; Hsu,Li-Ying; Wang,Mei-Li; Hsu,Kuo-Ying
    参考文献:Huadong Huagong Xueyuan Xuebao 日期:1981 卷标:(1) 页码:143-6]

    = 956-89-8 [标题:Reaction Conditions
    标题:Factors Influencing Regioselectivity In Lithium Aluminum Hydride Reduction Of Unsymmetrical Dicarboxylic Acids
    作者:Kayser,Margaret M.; Morand,Peter
    参考文献:Journal Of Organic Chemistry 日期:1979 卷标:44(8) 页码:1338-9]

    37742-98-6 = 956-89-8
    反应条件:1.1 Reagents: 1,3-Dichloro-5,5-Dimethylhydantoin Solvents: Ethanol; 2 H,40 °C
    标题:1,3-Dichloro-5,5-Dimethylhydantoin Promoted Esterification Of Carboxylic Acids Under Mild Conditions
    作者:Dong,Qing; Huang,Qingqiu; Wang,Mengke; Chen,Hongyan; Zi,You; Et Al
    参考文献:Tetrahedron Letters 日期:2022 卷标:112]

    37742-98-6 = 956-89-8
    反应条件:1.1 Reagents: Tetrapropylammonium Hydroxide Solvents: Acetonitrile,Methyl Ethyl Ketone,Water; 3 H,25 °C
    标题:A Two-Phase Bromination Process Using Tetraalkylammonium Hydroxide For The Practical Synthesis Of α-Bromolactones From Lactones
    作者:Yamamoto,Yuki; Tabuchi,Akihiro; Hosono,Kazumi; Ochi,Takanori; Yamazaki,Kento; Et Al
    参考文献:Beilstein Journal Of Organic Chemistry 日期:2021 卷标:17 页码:2906-2914]

    37742-98-6 = 956-89-8
    反应条件:1.1 Reagents: Phosphorus Pentachloride Solvents: Dichloromethane; 2 H,Rt1.2 Reagents: Tungsten Hexachloride; 26 H,Rt1.3 Solvents: Water; 12 H,Rt
    标题:Decarbonylation Of Phenylacetic Acids By High Valent Transition Metal Halides
    作者:Bartalucci,Niccolo; Marchetti,Fabio; Zacchini,Stefano; Pampaloni,Guido
    参考文献:Dalton Transactions 日期:2019 卷标:48(17) 页码:5725-5734]

    1251739-90-8 = 956-89-8
    反应条件:1.1 Reagents: Sodium Periodate Catalysts: Ruthenium Trichloride Solvents: Acetonitrile,Water1.2 Reagents: Sodium Borohydride Solvents: Methanol1.3 Reagents: P-Toluenesulfonic Acid Solvents: Acetonitrile; Overnight,Rt
    标题:Synthesis Of β,β-Disubstituted γ-Butyrolactones By Chemoselective Oxidation Of 1,4-Diols And γ-Hydroxy Olefins With Rucl3/naio4
    作者:Gao,Rong; Fan,Rong; Canney,Daniel J.
    参考文献:Synlett 日期:2015 卷标:26(5) 页码:661-665]

    = 956-89-8 [标题:Reaction Conditions
    标题:Synthesis Of Loperamide Hydrochloride
    作者:Zhang,Jiuzhi; Zhu,Leixin; Wu,Zuqi
    参考文献:Yiyao Gongye 日期:1987 卷标:18(10) 页码:442-4]

    14702-32-0 = 956-89-8 [标题:Reaction Conditions
    标题:Reversal Of Regioselectivity In The Reduction Of Gem-Disubstituted Cyclic Carboxylic Acid Anhydrides
    作者:Morand,Peter; Salvator,Judith; Kayser,Margaret M.
    参考文献:Journal Of The Chemical Society 日期:1982 卷标:(8) 页码:458-9]

    69177-61-3 = 956-89-8
    反应条件:1.1 Catalysts: Acetonitrile
    标题:Selective Oxidations Of Alcohols By Bromine In Combination With Nickel(Ii) Benzoate
    作者:Doyle,Michael P.; Dow,Robert L.
    参考文献:Synthetic Communications 日期:1980 卷标:10(11) 页码:881-8
📜二苯乙腈置于sodium Amide,苯体系中,化学反应生成 α,α-二苯基-γ-丁内酯
参考文献:Attenburrow Et Al.,Journal Of The Chemical Society,1939,P. 510,517
标题:Attenburrow Et Al.,Journal Of The Chemical Society,1939,P. 510,517

海关参考信息

专利信息


专利号:US-5130478-A
优先权日:1989-12-06
标题:Process for the preparation of chlorides of chlorinated carboxylic acids
发明人：GAUTHIER PATRICIA P; LE MOULT MICHEL M; ROCHELLE CLAUDE; SENET JEAN-PIERRE G
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:The invention relates to a process for the preparation of chlorides of chlorinated carboxylic acids of formula in which R2 denotes the radical (CH2)n, n being an integer from 2 to 4, or the radical -CH2-C(C6H5)2- and R1 denotes a hydrogen atom or an alkyl radical containing from 1 to 4 carbon atoms, which consists in reacting the lactones of formula in which R1 and R2 have the above meanings, with phosgene at a temperature of 90 DEG to 180 DEG C., while employing as catalysts trisubstituted phosphine oxides or sulphides. The process according to the invention makes it possible to obtain chlorides of chlorinated carboxylic acids of high purity which exhibit an excellent stability to light and to heat and which are very useful as synthesis intermediates.

专利号:US-3714159-A
优先权日:1971-03-30
标 题:2,2-diaryl-4-(4'-aryl-4'-hydroxy-piper-idino)-butyramides
发明人：JANSSEN P; NIEMEGEERS C; STOKBROEKX R; VANDENBERK J
权利人:JANSSEN PHARMACEUTICA NV
摘要:COMPOUNDS OF THE CLASS OF 2,2-DIARYL-4-(4''-ARYL-4''HYDROXY-PIPERIDINO)BUTYRAMIDES WHEREIN SAID ARYL AND SAID AMIDE FUNCTIONS ARE VARIOUSLY DEFINED GROUPS, SAID BUTURAMIDES HAVING ANTI-DIARRHEAL AND ANALGESIC ACTVITES; ALSO INCLUDED ARE NOVEL INTERMEDIATES USED IN THE SYNTHESIS OF SAID BUTYRAMIDES.

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合成参考文献


摘要:Anderson, E. A.; Gockel, B., Science of Synthesis Knowledge Updates, (2010) 3, 207.
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