CAS: 931-61-3; 2-Methylaminopyrimidine

该化合物是作为制药和农用化学材料的一个构件,其基脚架在参与氢联结和浸泡相互作用,加强其分子识别和药物设计方面的效用方面引人注目.该化合物在标准条件下表现出适度稳定,便于处理和储存.它的再活动使得进一步功能化,使其对医药化学的衍生具有价值.N-M-M-M-HIV-HIVirimidimidin-2胺通常用于生物活性分子合成,包括活性抑制剂和抗微生物剂.

结构式图片

相似化合物

859957-10-1 109-12-6 4214-72-6

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

CAS号1722-12-9 2-氯嘧啶 | CAS号74-89-5 氨基甲烷 | CAS号62062-31-1 1,2-dihydro-1-m... | CAS号31402-54-7 5-溴-2-甲基氨基嘧啶 | CAS号5621-02-3 2-二甲氨基嘧啶

合成工艺路线路线简述

  • 109-12-6 = 931-61-3
    反应条件:1.1 Solvents: Toluene
    标题:The Chemistry Of The Alkali Amides. Iii
    作者:Levine,Robert; Fernelius,W. Conard
    参考文献:Chemical Reviews (Washington 日期:1954 卷标:54 页码:449-573]

    1722-12-9 = 931-61-3
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Methanol; Overnight,Rt -> 80 °C; 80 °C -> Rt
    标题:Preparation Of Heteroaryloxotetrahydrodiazepinoindolecarboxamide Derivatives And Analogs For Use As Rsk Inhibitors
    参考文献:World Intellectual Property Organization]

    = 931-61-3 [标题:Reaction Conditions
    标题:Preparation Of 2-Aminopyrimidines And Their Use For Treatment Of Hypertension And Congestive Heart Failure
    参考文献:Japan]

    62062-31-1 = 931-61-3
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol; 48 H,Reflux
    标题:Method For Preparation Of 1-Methyl-5-Aryl-2-Aminoimidazoles And Their Reactivity
    作者:Smirnova,T. A.; Kurapov,P. B.; Vetrova,E. L.; Bass,A. G.; Nam,N. L.
    参考文献:Izvestiya Timiryazevskoi Sel'Skokhozyaistvennoi Akademii 日期:2003 卷标:(4) 页码:132-141]

    1722-12-9 = 931-61-3
    反应条件:1.1 Solvents: Tetrahydrofuran,Water; 1 H,0 °C -> Reflux
    标题:Hit-To-Lead Optimization Of Novel Phenyl Imidazole Carboxamides That Are Active Against Leishmania Donovani
    作者:Mcnamara,Nicole; Saunders,Eleanor; Varghese,Swapna; Zheng,Rebecca; Simpson,Kaylene; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2022 卷标:240]

    1722-12-9 = 931-61-3
    反应条件:1.1 Reagents: Triethylamine Solvents: Ethanol,Water; 15 H,80 °C
    标题:N-Methylamino Pyrimidyl Amides (Mapa): Highly Reactive,Electronically-Activated Amides In Catalytic N-C(O) Cleavage
    作者:Meng,Guangrong; Lalancette,Roger; Szostak,Roman; Szostak,Michal
    参考文献:Organic Letters 日期:2017 卷标:19(17) 页码:4656-4659]

    1722-12-9 = 931-61-3
    反应条件:1.1 Solvents: Ethanol
    标题:Monomer Synthesis. Ix. Methylation Of 2-Aminopyridine
    作者:Overberger,C. G.; Kogon,Irving C.
    参考文献:Journal Of The American Chemical Society 日期:1954 卷标:76 页码:1065-8]

    1722-12-9 = 931-61-3
    反应条件:1.1 Reagents: Potassium Fluoride Solvents: Water; 17 H,Rt -> 100 °C1.2 Reagents: Potassium Carbonate Solvents: Water; Cooled
    标题:Palladium-Catalyzed Remote C-H Functionalization Of 2-Aminopyrimidines
    作者:Das,Animesh; Jana,Akash; Maji,Biplab
    参考文献:Chemical Communications (Cambridge 日期:2020 卷标:56(31) 页码:4284-4287]

    1722-12-9 = 931-61-3
    反应条件:1.1 Reagents: Triethylamine Solvents: Ethanol
    标题:New 5-Aryl-1H-Imidazoles Display In Vitro Antitumor Activity Against Apoptosis-Resistant Cancer Models,Including Melanomas,Through Mitochondrial Targeting
    作者:Mathieu,Veronique; Van Den Berge,Emilie; Ceusters,Justine; Konopka,Tomasz; Cops,Antonin; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2013 卷标:56(17) 页码:6626-6637]

    109-12-6 = 931-61-3
    反应条件:1.1 Solvents: Acetone; 15 H,75 °C; 75 °C -> Rt1.2 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 0.5 H,80 °C
    标题:Substituted 4-Phenyl-2-Aminoimidazoles And 4-Phenyl-4,5-Dihydro-2-Aminoimidazoles As Voltage-Gated Sodium Channel Modulators
    作者:Zidar,Nace; Jakopin,Ziga; Madge,David J.; Chan,Fiona; Tytgat,Jan; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2014 卷标:74 页码:23-30]

    1003-58-3 = 931-61-3
    反应条件:1.1 Solvents: Water
    标题:Simple Pyrimidines. Iii. Methylation And Structure Of The Aminopyrimidines
    作者:Brown,D. J.; Hoerger,Earl; Mason,S. F.
    参考文献:Journal Of The Chemical Society 日期:1955 卷标:4035 页码:4035-40]

    1722-12-9 = 931-61-3
    反应条件:1.1 Solvents: Ethanol
    标题:2-(Dimethylamino)Pyrimidine
    作者:Overberger,C. G.; Kogon,Irving C.; Minin,Ronald
    参考文献:Organic Syntheses 日期:1955 卷标:35 页码:58-9]

    1722-12-9 = 931-61-3
    反应条件:1.1 Solvents: Ethanol; 1 H,150 °C
    标题:Compositions Providing Enhanced Antibacterial Activity Against Gram-Positive Bacteria And Use Thereof
    参考文献:World Intellectual Property Organization]

    1722-12-9 = 931-61-3
    反应条件:1.1 Solvents: Tetrahydrofuran,Water; 0 °C; 1 H,50 °C
    标题:Preparation Of Substituted Thiazoles As Tubulin Polymerization Inhibitors Useful In The Treatment Of Cancer
    参考文献:World Intellectual Property Organization]

    86755-91-1 = 931-61-3
    反应条件:1.1 Catalysts: Phenylmagnesium Bromide
    标题:The Role Of Chelation In The Formylation Of Grignard Reagents With N-Formyl Amines
    作者:Amaratunga,Wimal; Frechet,Jean M. J.
    参考文献:Tetrahedron Letters 日期:1983 卷标:24(11) 页码:1143-6]

    = 931-61-3 [标题:Reaction Conditions
    标题:A Divergent Synthesis Of Substituted 2-Aminoimidazoles From 2-Aminopyrimidines
    作者:Ermolat'Ev,Denis S.; Van Der Eycken,Erik V.
    参考文献:Journal Of Organic Chemistry 日期:2008 卷标:73(17) 页码:6691-6697
📜2-Aminopyrimidine Methoiodide置于sodium Hydroxide体系中,化学反应生成 2-甲氨基嘧啶
参考文献:中离子化合物.第12部分.1-烷基-4-氧嘧啶基-[1,2-A]-S-三叠氮酸酯及其4-硫代衍生物的合成
标题:中离子化合物.第12部分.1-烷基-4-氧嘧啶基-[1,2-A]-S-三叠氮酸酯及其4-硫代衍生物的合成
摘要:用乙氧基羰基异氰酸酯处理2-烷基氨基嘧啶(1)和(2),得到无环脲衍生物,即3-烷基-1-乙氧基羰基-3-(2-嘧啶基)脲(3)和(4),其环化为1-烷基-4-Oxopyrimido-[1,2一]-小号在回流的-三嗪-1-鎓-2-Olates(6)和(7)p二甲苯.通过光谱分析和另一种合成方法得到结构证明,其中(1)和(2)与苯氧羰基异氰酸酯反应.
DOI:10.1039/p19810000331

海关参考信息

专利信息


专利号:WO-9931124-A1
优先权日:1997-12-12
标 题:Cholic acid-based scaffolds for multidimensional molecular presentation of peptides
发明人：HOEEG-JENSEN THOMAS
权利人:NOVO NORDISK AS; HOEEG JENSEN THOMAS
摘要:A solid phase method for the synthesis of a plurality of differently substituted cholic acid scaffolds with a wide variety of peptide chain, pseudo-peptide chain or peptoid chain substitutents, as leads or compounds of potential therapeutic interest. The substituted cholic acids are prepared by initial solution synthesis of a scaffold holding amino acids with 3 orthogonal protecting groups. Subsequent solid-phase synthesis provides the build-up of the target molecules, either as discretes or in mixture. The molecules may be screened on the resin or cleaved from the resin and then screened in solution. The method disclosed here provides an easy and fast access to highly diverse compounds, potential peptide mimetics and potential leads for compounds of therapeutic interest. The method is amenable to automatization.

专利号:US-9550000-B2
优先权日:2011-09-09
标题 :Compositions, methods, and systems for the synthesis and use of imaging agents
发明人：ROBINSON SIMON P; YU MING
权利人:ROBINSON SIMON P; YU MING; LANTHEUS MEDICAL IMAGING INC
摘要:The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.

专利号:US-7354923-B2
优先权日:2001-08-10
标 题 :Piperazine melanocortin-specific compounds
发明人：SHARMA SHUBH D; SHI YI-QUN; WU ZHIJUN; RAJPUROHIT RAMESH
权利人:PALATIN TECHNOLOGIES INC
摘要:Melanocortin receptor-specific piperazine or ketopiperazine compounds having the structure: n nand stereoisomer and pharmaceutically acceptable salts thereof, where X is CH 2 or Câ•?O, R 1 , R 2 , and R 3 are as described in the specification, preferably where R 3 is a D-amino acid with at least one substituted or unsubstituted phenyl or naphthyl aromatic ring, and where R 3 optionally further includes an amine capping group, a second amino acid residue or a second amino acid residue with an amine capping group, which compounds are agonists, antagonists or mixed agonists and antagonists at one or more melanocortin receptors, and having utility in the treatment of melanocortin receptor-related disorders and conditions. Methods of synthesis of compounds of structure (I), pharmaceutical compositions containing a compound of structure (I) and methods relating to the use thereof are also disclosed.

专利号:CN-1035555-C
优先权日:1991-05-21
标题 :Method for diastereoselective synthesis of nucleosides

专利号:CN-114315737-A
优先权日:2021-12-13
标题:A kind of method for catalyzing the synthesis of N-arylation derivatives of pyrimidine-2-amine

专利号:CN-114761026-A
优先权日:2019-10-10
标 题:Compositions and methods for in vivo synthesis of non-natural polypeptides

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主要参考文献

参考标题:A Facile Synthesis Of Trifluoromethylamines By Oxidative Desulfurization-Fluorination Of Dithiocarbamates
作者:Kiyoshi Kanie,Katsuya Mizuno,Manabu Kuroboshi,Tamejiro Hiyama |发布日期:1998.8
摘要:Conditions. When This Reaction Was Applied To Dithiocarbamates Arn(R)Cs2Me At Higher Temperatures, The Trifluoromethylation Was Accompanied By Halogen Substitution At The P-Position Of The Ar Group. The Synthesis Of Trifluoromethyl-Substituted Adenosine Is Also Described.

合成参考文献


摘要:Solorio-Alvarado, C. R., Science of Synthesis: Hypervalent Halogens in Organic Synthesis, (2025) .
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