CAS: 89673-71-2; (S)-2-Hydroxypropanamide

该化合物是一种手性有机化合物,其特征是氢氧基组和一个附属于丙基骨的薄膜功能组,其立体特性(S)配置使其在不对称合成和制药应用中具有宝贵价值,在这种应用中,对应纯度至关重要.该化合物是生产精细化学品,生物活性分子和手性催化剂的多种中间体.其氢氧和氨化功能能够参与氢的结合和进一步衍生,加强其在医药化学和材料科学中的效用.可达到高纯度的研究和工业要求,确保合成途径的再生性.建议适当处理和储存以维持稳定.

英文名称(S)-2-Hydroxypropanamide
中文名称(S)-2-羟基丙酰胺
IUPAC名称(S)-2-hydroxypropanamide
其它别名(S)-(-)-2-羟基丙酰胺; L-(-)-Lactamide For Synthesis
CAS编号89673-71-2
MFCD编号:MFCD00198010
EINECS号:966-539-7
分子式:C3H7NO2分子量:89.09
产品CID: 1918470
产品分类有机原料→分子砌块→手性化合物→手性砌块

相似结构搜索
InChIKey: SXQFCVDSOLSHOQ-REOHCLBHSA-N
InChI=1S/C3H7NO2/c1-2(5)3(4)6/h2,5H,1H3,(H2,4,6)/t2-/m0/s1
计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数1.0

相似化合物

598-81-2 2043-43-8 78-96-6

MSDS等安全信息

GHS符号GHS07
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P280-P302+P352
UN编号NONH for all modes of transport
危险品标志T
安全声明26-36/37/39-45
危险类别码23/24/25-36/37/38
WGK Germany3

欧盟法规

C&L通报

上下游产品

ethyl 2-hydroxypropionate 2-(2-hydroxy-1-oxopropoxy)propionic acid 2-hydroxy-propionitrile O-acetyl-lactic acid acetylamide acrylonitrile lactic acid hydroxymethylamide 2-n-Hexyl-5-methyl-oxazol p-Lactophenetide

合成工艺路线路线简述

687-47-8 = 89673-71-2
反应条件:1.1 Reagents: Ammonia Solvents: Methanol; 5 °C; 24 H,Rt
标题:Synthesis And Biological Activity Of Novel Ester Derivatives Of N3-(4-Metoxyfumaroyl)-(S)-2,3-Diaminopropanoic Acid Containing Amide And Keto Function As Inhibitors Of Glucosamine-6-Phosphate Synthase
作者:Pawlak,Dorota; Schielmann,Marta; Wojciechowski,Marek; Andruszkiewicz,Ryszard
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2016 卷标:26(15) 页码:3586-3589]

27871-49-4 = 89673-71-2
反应条件:1.1 Reagents: Ammonia Solvents: Methanol
标题:Syntheses And Biological Evaluation Of Peptides Containing A Transition-State Isostere: The Chemistry Of Functionalized Sulfonamides In The Quest For Protease Inhibitors And Catalytic Antibodies
作者:Moree,Willy Jantina
参考文献:1994]

687-47-8 = 89673-71-2 [标题:Reaction Conditions
标题:A General Synthetic Method Of Chiral 2-Arylalkanoic Esters Via Thermal 1,2-Rearrangement
作者:Honda,Yutaka; Ori,Aiichiro; Tsuchihashi,Genichi
参考文献:Bulletin Of The Chemical Society Of Japan 日期:1987 卷标:60(3) 页码:1027-36]

5875-25-2 = 89673-71-2
反应条件:1.1 Catalysts: (S)-2-Haloacid Dehalogenase Solvents: Dimethyl Sulfoxide,Water; 30 °C
标题:Substrate Specificity And Product Stereochemistry In The Dehalogenation Of 2-Haloacids With The Crude Enzyme Preparation From Pseudomonas Putida
作者:Vyazmensky,Maria; Geresh,Shimona
参考文献:Enzyme And Microbial Technology 日期:1998 卷标:22(5) 页码:323-328

海关参考信息

2905122000-异丙醇
2912110000-甲醛
2912120000-乙醛
2922110001-单乙醇胺
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合成参考文献

参考文献:10.1007/s00253-014-6114-8
摘要:Wang J, Zhu Y, Zhao G, Zhu J, Wu S. Characterization of a recombinant (+)-γ-lactamase from Microbacterium hydrocarbonoxydans which provides evidence that two enantiocomplementary γ-lactamases are in the strain. Applied Microbiology and Biotechnology. 2014 Oct 24;99(7):3069–80. doi: 10.1007/s00253-014-6114-8.
参考文献:10.1007/s00253-002-0943-6
摘要:Neumann S, Kula M-. Gene cloning, overexpression and biochemical characterization of the peptide amidase from Stenotrophomonas maltophilia. Applied Microbiology and Biotechnology. 2002 Mar 08;58(6):772–80. doi: 10.1007/s00253-002-0943-6.