CAS: 87081-35-4; (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-Ethyl-6-Hydroxy-3,5,7,9,11,15-Hexamethyl-19-((2S,3S)-3-Methyl-6-Oxo-3,6-Dihydro-2H-Pyran-2-yl)-8-Oxononadeca-2,10,12,16,18-Pentaenoic Acid

上下游产品

CAS号217640-04-5 (2R,3S)-1-(benz... | CAS号217640-11-4 (S)-4-isopropyl... | CAS号217640-14-7 (2S,3R,4S,E)-3-...

📜(2S,3S)-2-[(1E,3Z,5R)-3-Ethyl-7-Hydroxy-5-Methylhepta-1,3-Dienyl]-3-Methyl-2,3-Dihydropyran-6-One置于吡啶,Manganese(Iv) Oxide,Sodium Chlorite,Sodium Dihydrogenphosphate,双氧水,Dimsyl Lithium,戴斯-马丁氧化剂,氟化氢吡啶体系中,用 四氢呋喃,二氯甲烷,甲苯,乙腈,苯 作为反应溶剂,化学反应生成 来普霉素b
参考文献:Absolute Stereostructure And Total Synthesis Of Leptomycin B
标题:Absolute Stereostructure And Total Synthesis Of Leptomycin B
摘要:The Absolute Stereostructure Of Leptomycin B,An Antitumor Antibiotic And Inhibitor Of Nuclear Protein Export,Was Firstly Presumed As 1 Having 4S,5R,10R,16R,18S,19R,20S On The Basis Of NMR Comparison With Callystatin A (2) And Then 1 Was Asymmetrically Synthesized. The Synthesized Leptomycin B (I) Was Found Identical With The Authentic Sample In HPLC And Cd Comparison As Well As In Other Respects. This Structural Elucidation Of The Absolute Stereostructure And Total Synthesis Are The First Example;Among The Leptomycin Family As Streptomyces Metabolites. (C) 1998 Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0040-4039(98)01809-7

专利信息

专利号:US-10029014-B2
优先权日:2013-09-10
标题:Synthesis of novel asymmetric bow-tie PAMAM dendrimer-based conjugates for tumor-targeting drug delivery
发明人：OJIMA IWAO; WANG TAO; TENG YU-HAN
权利人:UNIV NEW YORK STATE RES FOUND
摘要:The present disclosure relates to a dendrimer-based conjugate of the formula V m -D-C-D′-(T-F) n , which is useful for tumor targeting drug delivery. The use of asymmetric dendrimers allow for specific targeting as well as synthetic reproducibility.

专利号:US-11946086-B2
优先权日:2017-01-05
标题 :Gene involved in synthesis of cyclic peptide compound, method for producing cyclic peptide compound using the same, and transformant comprising the same
发明人：KUBO TAKASHI; MACHIDA MASAYUKI; UMEMURA MAIKO; ABE KEIETSU; YOSHIMI AKIRA; FUJIOKA TOMONORI; YAMAGUCHI Shigenari; KAWAI KIYOSHI
权利人:AIST; UNIV TOHOKU; KUMIAI CHEMICAL INDUSTRY CO
摘要:This invention is intended to identify a gene cluster involved in biosynthesis of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species and to establish a system for synthesizing such cyclic peptide compound. The gene is composed of a first module to a tenth module and encodes a protein having activity of synthesizing a nonribosomal peptide constituting a basic peptide backbone of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species.

专利号:US-2022259634-A1
优先权日:2017-01-05
标题:Gene involved in synthesis of cyclic peptide compound, method for producing cyclic peptide compound using the same, and transformant comprising the same

专利号:US-11712432-B2
优先权日:2018-12-20
标题 :Method of treating cancer with an elevated glycogen content
发明人：GENTRY MATTHEW S; SUN RAMON C; YOUNG LYNDSAY EA
权利人:UNIV KENTUCKY RES FOUND
摘要:A method of treating cancer is provided. The method includes administering to a subject in need thereof an effective amount of a compound selected from the group consisting of a glycogen phosphorylase inhibitor, a glycogen synthase inhibitor, a glycogen degradation molecule, an anti-sense oligonucleotide that down-regulates glycogen synthesis, and combinations thereof, where the cancer includes elevated levels of glycogen.

专利号:CN-111684066-B
优先权日:2017-01-05
标题 :Genes related to the synthesis of cyclic peptide compounds, methods for producing cyclic peptide compounds using the genes, and transformants having the genes

专利号:US-2016220688-A1
优先权日:2013-09-10
标题:Synthesis of novel asymmetric bow-tie pamam dendrimer-based conjugates for tumor-targeting drug delivery