CAS: 7431-89-2; (S)-6-Amino-2-(Methylamino)Hexanoic Acid

该化合物是一种经修改的氨酸衍生物,通常用于生化和制药研究,其主要结构特征是甲型氨基组的甲基化,将其与原生林素区别开来,使其对研究酶-基相互作用,特别是在赖氨酸特定过程中的酶-基相互作用很有价值.盐盐的盐状可以提高溶解性和稳定性,促进其在水溶液中的使用.该化合物对于调查转基因改变,甲基化途径和作为peptide合成的建筑块特别有用.其定义明确的化学特性和高纯度使它成为酶和分子生物学的机械研究的可靠试剂.

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相似化合物

105047-45-8 106719-44-2 115186-31-7

上下游产品

N6-benzoyl-N2-methyl-N2-(toluene-4-sulfonyl)-L-lysineN6-benzoyl-N2-methyl-N2-(toluene-4-sulfonyl)-L-lysine formaldehyd N6-benzoyl-L-lysineN6-benzoyl-L-lysine N6-benzoyl-N2-(toluene-4-sulfonyl)-L-lysineN6-benzoyl-N2-(toluene-4-sulfonyl)-L-lysine

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    专利信息


    专利号:US-12351573-B2
    优先权日:2019-05-09
    标 题:Compounds for use in synthesis of peptidomimetics
    发明人:AL-ABED YOUSEF; CHENG KAI FAN
    权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

    专利号:US-2023159450-A1
    优先权日:2020-05-08
    标 题 :Dimers for use in synthesis of peptidomimetics
    发明人:AL-ABED YOUSEF; ALTITI AHMAD
    权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.

    专利号:WO-2008105759-A1
    优先权日:2007-02-27
    标 题:Methods for synthesis of modified peptides
    发明人:BROWER JUSTIN O
    权利人:ARGOLYN BIOSCIENCE INC; BROWER JUSTIN O
    摘要:Methods for the synthesis of peptides and peptide analogs containing aminoacid residues bearing substituted amino- and guanido- sidechains, such as alkyl lysine and arginine residues, are provided.

    专利号:US-2024218014-A1
    优先权日:2022-11-21
    标 题:Synthesis of a cyclic peptide
    发明人:BAUR PIUS BRUNO; CLEATOR EDWARD; DENIAU GILDAS; EISELE FRANK; FLÖGEL OLIVER; HUSTE ANJA; KEHL MARCEL ROMAN; LÖWENECK MARKUS; SILVA ROLANDO RAVELO; VORBERG RAFFAEL
    权利人:JANSSEN PHARMACEUTICA NV
    摘要:Processes for performing peptide synthesis, particularly for cyclic peptide synthesis are generally described. Reaction intermediates of the peptide synthesis are also described.

    专利号:US-7635579-B2
    优先权日:1999-08-02
    标 题:Metabolic engineering of amino acid production
    发明人:RAYAPATI P JOHN; CRAFTON COREY M
    权利人:ARCHER DANIELS MIDLAND CO
    摘要:The present invention is directed towards the fermentative production of amino acids, providing microorganisms, methods and processes useful therefor. Microorganisms of the invention are capable of converting glucose to amino acids other than L-isoleucine, L-leucine and L-valine with greater efficiency than the parent strain. The efficiency of conversion may be quantified by the formula: [(g amino acid produced/g dextrose consumed)*100]=% Yield and expressed as yield from dextrose. The invention provides microorganisms that are made auxotrophic or bradytrophic for the synthesis of one or more branched chain amino acids by mutagenesis and selected for their ability to produce higher percent yields of the desired amino acid than the parental strain. Preferred microorganisms are Corynebacterium, Brevibacterium or Escherichia coli producing L-lysine. Mutagenesis is performed by classical techniques or through rDNA methodology. Methods of the invention are designed to increase the production of an amino acid by mutagenizing a parental strain, selecting cells auxotrophic or bradytrophic for the synthesis of one or more branched chain amino acids and selecting branched chain amino acid auxotrophs or bradytrophs that produce a higher percent yield from dextrose of the desired amino acid than the parental strain. Processes of the invention are designed for the production an amino acid comprising culturing in a medium a microorganism obtained by mutagenizing a parent strain to be auxotrophic or bradytrophic for branched chain amino acid synthesis and selecting variants that are capable of converting glucose to amino acids other than L-isoleucine, L-leucine and L-valine with greater efficiency than the parent strain.

    专利号:EP-1548006-B1
    优先权日:2003-12-12
    标题 :Synthesis of tetraazapentamethine derivatives, keratin fibers dyeing process which uses such synthesis
    发明人:PEREIRA RUI; BURGAUD HERVE
    权利人:OREAL
    摘要:Producing tetraazapentamethine compounds (I) comprising reacting an azine compound with an oxidizing agent, is new. Producing tetraazapentamethine compounds of formula (I) comprises reacting an azine compound of formula (VI) or (VII) with an oxidizing agent; [Image] [Image] W1a cationic heteroaromatic group of formula (II) or (III); W2a heteroaromatic group of formula (IV) or (V); Z14Z7 or Z1; Z15Z8 or Z2; Z16Z13 or Z0; R25R5 or R1; Z17Z9 or Z3; Z18Z10 or Z4; Z19Z11 or Z5; Z20Z12 or Z6; R26R8 or R3; R27R7 or R4; R28, R29H, 1-6C alkyl or 1-6C alkoxy, but not both H; Z0CR2, N or NR21; Z1O, S or NR9; Z2N or CR10; Z3N or CR11; Z4N or CR12; Z5N or CR13; Z5N or CR13; Z6N or CR14; Z7O, S or NR15; Z8N or CR16; Z9N or CR17; Z10N or CR18; Z11N or CR19; Z12N or CR20; Z13CR6, N or NR22; R2, R6, R10, R16H; 1-4C alkyl substituted with 0-3 of OH, 1-2C alkoxy, 2-4C (poly)hydroxyalkoxy, NH2, 1-2C (di)alkylamino, COOH or SO3H; phenyl substituted with 0-2 of OH, 1-2C alkoxy, 2-4C (poly)hydroxyalkoxy, NH2, 1-2C (di)alkylamino; COOH; sulfonylamino; R1, R4, R5, R7, R9, R15, R21, R221-6C alkyl substituted with 0-3 of OH, 1-2C alkoxy, 2-4C (poly)hydroxyalkoxy, NH2, 1-2C (di)alkylamino, COOH or SO3H; R0, R3, R8, R11-R14, R17-R20H; 1-6C linear or branched hydrocarbyl with 0-3 unsaturations, optionally substituted with 1-3 of OH, 1-2C alkoxy, 2-4C (poly)hydroxyalkoxy, NH2, 1-2C (di)alkylamino, COOH, SO3H, sulfonylamino, 2-4C (poly)hydroxyalkylamino or halo and optionally interrupted by O, N, S or SO2; phenyl optionally substituted with 1-3 of OH, 1-2C alkoxy, 2-4C (poly)hydroxyalkoxy, NH2, 1-2C (di)alkylamino, COOH, SO3H, sulfonylamino, 2-4C (poly)hydroxyalkylamino or halo; pyrazolyl, pyrrolyl, imidazolyl, thiazolyl, oxazolyl, triazolyl, pyridyl, pyrimidinyl, triazinyl, pyrazinyl or pyridazinyl; X : an anion; R2+R10, R11+R12, R6+R16, R17+R18 can form a 5-6C aromatic ring substituted with 0-2 of OH, NH2, 1-2C (di)alkylamino, 1-2C alkoxy, 2-4C (poly)hydroxyalkylamino. An independent claim is also included for dyeing keratinic fibers by applying (VI) or (VII) onto the wet or dry fibers in the presence of an oxidizing agent. [Image].

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    合成参考文献


    参考文献:10.1371/journal.pone.0022290
    摘要:Foreman KW, Brown M, Park F, Emtage S, Harriss J, Das C, Zhu L, Crew A, Arnold L, Shaaban S, Tucker P. Structural and Functional Profiling of the Human Histone Methyltransferase SMYD3. PLoS ONE. 2011 Jul 14;6(7):e22290. doi: 10.1371/journal.pone.0022290.
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