CAS: 71936-92-0; 1,2,3,4,10,14B-Hexahydrodibenzo[c,F]Pyrazino[1,2-A]Azepine

上下游产品

N-Cyanomianserin mianserin 2-(6,11-dihydro-5H-dibenzo[b,e]azepin-6-ylmethyl)isoindole-1,3-dione 2-benzylanilinemianserinmianserin (14BR)-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine mianserin

专利信息

专利号:WO-2023284262-A1
优先权日:2021-07-13
标 题 :3,4-fused seven-membered heterocyclic oxindole, synthesis method therefor and application thereof
发明人：Li shuai-shuai; HU FANGZHI; Ding Zhanshuai; LI XINYAO
权利人:UNIV QINGDAO AGRICULTURAL
摘要:Disclosed is a 3,4-fused seven-membered heterocyclic oxindole, a synthesis method therefor and an application thereof. A structure of a 3,4-fused seven-membered nitrogen heterocyclic oxindole is provided in the present invention. A method for synthesizing same is also provided, comprising the following steps: reacting propargyl alcohol containing an isatin framework with a nucleophile under specific conditions to prepare a 3,4-fused seven-membered nitrogen heterocyclic oxindole. A pharmaceutical composition is provided in the present invention. Also provided in the present invention is an application of a 3,4-fused seven-membered nitrogen heterocyclic oxindole in the preparation of a drug for treating cancer. Provided in the present invention is a method for efficiently synthesizing 3,4-fused seven-membered nitrogen heterocyclic oxindoles having different structures. This is the first time achieving efficient synthesis of bioactive molecules containing both benzazepine and 3,4-fused heterooxidized oxindole structures on the basis of a hydrogen migration strategy.

专利号:US-4217452-A
优先权日:1974-02-09
标 题:Synthesis for the preparation of tetracyclic compounds
发明人：OLIVIE JACQUES
权利人:AKZONA INC
摘要:The invention relates to a new synthesis for the preparation of tetracyclic compounds of the general formula: ##STR1## as well as the pharmaceutically acceptable salts thereof, in which: n is the number 1 or 2, n m is the number 1, if n=2 and the number 2, if n=1, n R 1 and R 2 stand for hydrogen, hydroxy, halogen, lower alkyl (1-4 C), lower alkoxy (1-4 C) or trifluoromethyl and n R 3 represents hydrogen, alkyl (1-6 C), aralkyl (7-10 C) or an amino alkyl group (1-6 C), in which the nitrogen atom has been substituted by two alkyl groups (1-4 C), or the nitrogen atom forms part of a heterocyclic 5- or 6-membered ring, n having valuable biological properties.

专利号:US-4254031-A
优先权日:1974-02-09
标 题:Synthesis for the preparation of tetracyclic compounds
发明人：OLIVIE JACQUES
权利人:AKZONA INC
摘要:The invention relates to a new synthesis for the preparation of tetracyclic compounds of the general formula ##STR1## as well as the pharmaceutically acceptable salts thereof, in which: n is the number 1 or 2, n m is the number 1, if n=2 and the number 2, if n=1, n R 1 and R 2 stand for hydrogen, hydroxy, halogen, lower alkyl (1-4 C), lower alkoxy (1-4 C) or trifluoromethyl and n R 3 represents hydrogen, alkyl (1-6 C), aralkyl (7-10 C) or an amino alkyl group (1-6 C), in which the nitrogen atom has been substituted by two alkyl groups (1-4 C), or the nitrogen atom forms part of a heterocyclic 5- or 6-membered ring, n having valuable biological properties.

专利号:US-4025513-A
优先权日:1974-02-09
标题:Synthesis for the preparation of tetracyclic compounds