CAS: 69-27-2; Chlorisondamine Diiodide,4,5,6,7-Tetrachloro-1,3-Dihydro-2-Methyl-2-[2-Trimethylammonium)Ethyl]-2H-Isoindoliumdiiodide

该化合物是一种属于四氟铵化合物类别的化学化合物,主要被确认为用作肌肉放松剂,并用于药理学.该化合物具有分解性质,能够与生物膜有效互动....

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CAS号632-58-6 四氯酞酸半水合物 | CAS号74-87-3 氯甲烷 | CAS号95467-71-3 N,N-dimethyl-2-...

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    专利号:US-10925977-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
    发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
    权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
    摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

    专利号:US-9315483-B2
    优先权日:2007-09-13
    标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
    发明人:JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT
    权利人:CONCERT PHARMACEUTICALS INC
    摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.

    专利号:US-10814013-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:WO-2009035652-A1
    优先权日:2007-09-13
    标 题 :Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof

    专利号:AU-2007308022-A2
    优先权日:2006-10-05
    标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:AU-2007308022-A1
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

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    1: Marenco T, Bernstein S, Cumming P, Clarke PB. Effects of nicotine and chlorisondamine on cerebral glucose utilization in immobilized and freely-moving rats. Br J Pharmacol. 2000 Jan;129(1):147-55. doi: 10.1038/sj.bjp.0703005.
    2: Chadman KK, Woods JH, Stitzel J. Chlorisondamine inhibits the nicotine- induced stimulation of c-fos in the pigeon brain for up to 2 weeks. Nicotine Tob Res. 2007 Sep;9(9):927-36. doi: 10.1080/14622200701540838. 308(1):73-8. doi: 10.1124/jpet.103.057307. Epub 2003 Oct 17. 111(2):397-405. doi: 10.1111/j.1476-5381.1994.tb14748.x.
    5: el-Bizri H, Clarke PB. Blockade of nicotinic receptor-mediated release of dopamine from striatal synaptosomes by chlorisondamine administered in vivo. Br J Pharmacol. 1994 Feb;111(2):414-8. doi: 10.1111/j.1476-5381.1994.tb14750.x.

    合成参考文献


    摘要:Bollettino Chimico Farmaceutico., 103(490), 1964 []
    摘要:Journal of Pharmacology and Experimental Therapeutics., 115(172), 1955 []
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