CAS: 609-67-6; 2-Iodobenzoylchloride

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CAS号88-67-5 邻碘苯甲酸 | CAS号79-37-8 草酰氯 | CAS号75-09-2 二氯甲烷 | CAS号118-92-3 邻氨基苯甲酸 | CAS号591-50-4 碘苯 | CAS号107624-39-5 2-IODO-4'-METHY... | CAS号109241-03-4 (2-iodophenyl)-... | CAS号108350-92-1 2-iodo-N,N-diph... | CAS号3930-83-4 2-碘苯甲酰胺 | CAS号144631-04-9 N-[2-(2-bromoph... | CAS号90034-85-8 (2-碘苯甲酰基)乙酸乙酯 | CAS号5022-29-7 N-乙基邻苯二甲酰亚胺 | CAS号444912-75-8 (2-碘苯基)(1-((1-甲... | CAS号947-84-2 2-苯基苯甲酸 | CAS号5159-41-1 2-碘苄醇

📜2-碘苯甲酸置于草酰氯,N,N-二甲基甲酰胺体系中,用 二氯甲烷 作为反应溶剂,以100%的收率获得产物邻碘苯甲酰氯
参考文献:用(tms)2 Nh,苯乙烯,Nis和t Buok将芳基2-碘苯基酮新型转化为1,3-二芳基异喹啉
标题:用(tms)2 Nh,苯乙烯,Nis和t Buok将芳基2-碘苯基酮新型转化为1,3-二芳基异喹啉
摘要:在温热条件下,在sc(otf)3存在下,用tms 2 Nh处理芳基2-碘苯基酮,然后与苯乙烯和nis反应,得到n-(1-芳基-2-碘乙基)芳基2-碘苯基酮亚胺.在1,10-菲咯啉存在下,在120oc下用t Buok对n-(1-芳基-2-碘乙基)芳基2-碘苯基酮亚胺进行进一步处理,通过set将t Buok转化为1,3-二芳基异喹啉碘苯基基团形成芳基,它们的6-Endo-Trig环化到乙烯基上,以及环化中间体的芳构化.本方法是由芳基2-碘苯基酮经两个步骤制备异喹啉核心的新颖方法.©2020爱思唯尔科学.版权所有.
DOI:10.1016/j.Tet.2020.131864

专利信息

专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:US-6603070-B2
优先权日:2000-07-21
标题 :Convergent synthesis of multiporphyrin light-harvesting rods
发明人：LINDSEY JONATHAN S; LOEWE ROBERT S
权利人:UNIV NORTH CAROLINA STATE
摘要:The present invention provides a convergent method for the synthesis of light harvesting rods. The rods are oligomers of the formula A 1 (A b+1 ) b , wherein b is at least 1, A 1 through A b+1 are covalently coupled rod segments, and each rod segment A 1 through A 1+b comprises a compound of the formula X 1 (X m+1 ) m wherein m is at least 1 and X 1 through X m+1 are covalently coupled porphyrinic macrocycles. Light harvesting arrays and solar cells containing such light harvesting rods are also described, along with intermediates useful in such methods and rods produced by such methods.

专利号:US-2003111108-A1
优先权日:2000-07-21
标题:Convergent synthesis of multiporphyrin light-harvesting rods

专利号:US-2007099919-A1
优先权日:2005-10-06
标题 :Composition and synthesis of new reagents for inhibition of HIV replication

专利号:US-7754773-B2
优先权日:2005-10-06
标 题:Composition and synthesis of new reagents for inhibition of HIV replication
发明人：RANA TARIQ M; STEVENSON MARIO; NATHANS ROBIN SCOTT; CAO HONG; ALI AKBAR
权利人:UNIV MASSACHUSETTS
摘要:The present invention provides compounds and compositions for inhibiting Vif and methods for treating viral infection, e.g., HIV infection.

专利号:WO-2007044565-A2
优先权日:2005-10-06
标 题 :Composition and synthesis of new reagents for inhibition of hiv replication