CAS: 56-39-3; 2-Aminoacetic Acid

📜Nitroethanoic Acid-1-14C置于5%-Palladium/activated Carbon,氢气,溶剂黄146体系中,用 水 作为反应溶剂,以30 Mg的收率获得产物甘氨酸-1-14C
参考文献:一种甘氨酸-1-
标题:一种甘氨酸-1-
摘要:本发明公开了一种甘氨酸‑1‑14C的制备方法,包括以下步骤:(1)在惰性气体保护下,无水硝基甲烷与金属或者金属有机试剂在无水醚类溶剂中形成硝基甲烷盐溶液,然后与14Co2进行反应得到硝基乙酸‑1‑14C粗品;所述的14Co2通过碳酸钡‑14C的酸解得到;(2)在钯炭催化剂的作用下,硝基乙酸‑1‑14C粗品与氢气进行还原反应,反应结束后经过后处理得到所述的甘氨酸‑1‑14C.该方法合成步骤短,反应条件温和可控,不需要高温高压等严苛条件,也不需要使用强腐蚀性,剧毒等危险化学品,并且易于微量合成,成本低,14C利用率高,最后纯化得到的产品纯度高,状态好,比活度降低小.

专利信息

专利号:US-9597417-B2
优先权日:2013-11-08
标 题 :Compositions and methods to evaluate hepatobiliary/gastrointestinal health, enterohepatic circulation, and drug interactions
发明人：POLLI JAMES E; RAUFMAN JEAN-PIERRE; VIVIAN DIANA
权利人:THE US DEPT OF VETERAN AFFAIRS; UNIV MARYLAND; THE US DEPARTMETN OF VETERANS AFFAIRS
摘要:The present invention relates to the synthesis and use of a novel trifluorinated bile acid analog, that being, CA-sar-TFMA which is useful as an imaging probe, diagnostic agent or contrast agent and is resistant to bacterial deconjugation, wherein the trifluorinated bile acid analog can be used as a 19 F MRI tracer exhibiting an increased half-life due to its resistance to choloylglycine hydrolase.