CAS: 48208-26-0; (S)-2-(1,3-Dioxoisoindolin-2-yl)-3-(1H-Indol-3-yl)Propanoic Acid

上下游产品

phthalic anhydride L-Tryptophan L-tryptophan hydr°Chloride methyl 2-(N-succinimidyloxycarbonyl)benzoatebenzyl (S)-N-phthaloyltryptophanyl-(S)-prolinate 26H19FN2O4C26H19FN2O4 N-Phth-Trp-Phe-OMe 35H36N4O6C35H36N4O6

📜N-乙氧羰基邻苯二甲酰亚胺,L-色氨酸置于sodium Carbonate体系中,用 水 作为反应溶剂,化学反应 5.0H,反应生成 N-酞酰-L-色氨酸
参考文献:用于确定α-氨基酸衍生物绝对构型的手性传感器
标题:用于确定α-氨基酸衍生物绝对构型的手性传感器
摘要:通过比较在(R)-Csa 1和(S)存在下n-邻苯二甲酰基保护的α-氨基酸的α氢的质子NMR化学位移值,开发了一种简单的α-氨基酸构型分配策略-Csa 1.可以在NMR管中直接在手性溶剂化剂与n-邻苯二甲酰基保护的α-氨基酸的混合溶液上获得高分辨的NMR光谱,从而给出可明显区分的质子信号而不会产生干扰,从而显着提高了分配的准确性并加快了分配过程.该策略广泛适用于各种天然和非天然氨基酸.
DOI:10.1039/c8Ob01933A

专利信息

专利号:US-2024066133-A1
优先权日:2020-03-06
标 题 :Therapeutic agents and conjugates thereof
发明人：SONG YUNTAO; LI ANRONG; LI HUI; LI XIANFENG; YANG JUNBAO
权利人:BEIJING XUANYI PHARMASCIENCES CO LTD
摘要:The present disclosure provides a class of conjugates of general formula (X), a class of TLR9 agonist derivatives, such as formula (I), (XX), and (XXI), certain diastereomers of STING agonists, a class of STING agonist derivatives, such as formula (XXVIV), a class of heterocyclic compounds of general formula (II), a class of heterocyclic compounds of general formula (III), as defined herein. A 1 , A 2 , T, Z 1 , Z 2 , Z 3 , b 1 , and b 2 , in formula (X) are defined herein. The conjugate provides unique properties that are based upon the properties of the therapeutic agents that are part of the conjugate. Also provided are methods of synthesis and use of compounds.

专利号:US-12102685-B2
优先权日:2020-03-26
标 题:Immodulator peptides covalently modified with small molecules
发明人：MASCARENHAS DESMOND
权利人:MASCARENHAS DESMOND
摘要:This invention provides modified IGFBP-derived peptides—collectively termed “immodulator peptidesâ€?—and related compositions and methods. Chemical modifications to peptides using small molecules, and sequence extensions to immodulator core sequences exhibit new and surprising biological activities. The invention builds the combinatorial power of the immodulator peptide class further by demonstrating which core sequences bind metal or glycosaminoglycans such as heparin. The invention discloses some surprising biological properties of compositions derived from these modifications, including a host of new therapeutic and diagnostic utilities (e.g. immune modulation of TLR signaling, enhanced collagen synthesis by skin fibroblasts, and synergy with a RIG-I agonist in killing melanoma cells). The invention also teaches methods for enhancing previously disclosed uses of immodulator peptides by showing how the modifications of the invention can boost the efficacy of immodulator peptides in a model of burn trauma.

专利号:US-11674950-B2
优先权日:2017-10-31
标题 :Methods determining and treating cellular resistance to ADP-rtbosylating toxin
发明人：LANE ANDREW; ASTER JON
权利人:DANA FARBER CANCER INST INC; BRIGHAM & WOMENS HOSPITAL INC
摘要:The present invention is based in part on the identification of DPH1 and other members of the diphthamide synthesis pathway as biomarkers of resistance to an ADP-ribosylating toxin in a cell, and methods for identification, assessment, and treatment of a condition that is resistant to an ADP-ribosylating toxin.