CAS: 4641-57-0; 1-Phenyl-2-Pyrrolidinone

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N-苯基哌啶置于亚硝酸特丁酯,2,2,6,6-Tetramethylpiperidine-1-Oxoammonium Tetrafluoroborate,氯化铵,三氟乙酸,锌体系中,用 四氢呋喃,1,4-二氧六环,水 作为反应溶剂,化学反应 15.0H,反应生成 1-苯基-2-吡咯烷酮
参考文献:由t Buono促进的n-芳基哌啶的c-c / C-n键的选择性切割和可调功能
标题:由t Buono促进的n-芳基哌啶的c-c / C-n键的选择性切割和可调功能
摘要:本文提出了在无金属条件下t Buono促进的n-芳基哌啶中惰性cc-C / C-N键的选择性裂解和可调功能.具体而言,当反应在分子筛存在下在乙腈中进行时,形成了合成上有用的无环n-甲酰基腈.另一方面,当使用醇作为反应介质时,相应的反应通过机理上不同的途径提供了n-亚硝基链酯作为主要产物.
DOI:10.1021/acs.Orglett.9B00226

专利信息

专利号:US-9453044-B2
优先权日:2012-02-07
标题 :Method of synthesizing peptides, proteins and bioconjugates
发明人：LIU CHUAN FA; ZHAO JUNFENG
权利人:UNIV NANYANG TECH
摘要:The invention relates to the synthesis of peptides, proteins and related bioconjugates, and in particular, to such synthesis using a peptide ligation method whereby a C-terminal salicylaldehyde ester peptide is reacted with an aminoacyl-N-hydroxl peptide. The invention also relates to the synthesis of cyclic peptides, including serinyl- or threonyl-containing cyclic peptides. The invention further relates to a solid phase synthesis of C-terminal salicylaldehyde ester peptides.

专利号:US-6841559-B1
优先权日:1999-11-19
标 题:Pyridinones to treat and prevent bacterial infections
发明人：ALMQVIST FREDERIC; EMTENAS HANS; HULTGREN SCOTT J; PINKNER JEROME S
权利人:WASHINGTON UNIVERSITY OF ST LO
摘要:Novel pyridinones and their derivatives which are effective in treating or preventing Gram-negative bacterial infections are provided. The pyridinones are stable and easily derivatized; the methods by which these derivatizations occur is described. Two regioselective and functional group tolerant methods for the synthesis of the novel pyridinones are also provided. One such synthetic method involves reacting an imine and a Meldrum's acid derivative in solution. The other synthetic method is a solid phase synthesis of the pyridinones in which an imine is prepared bound to a solid support and a Meldrum's acid derivative is reacted with the imine. Novel imine intermediates useful in the solid phase and solution methods of synthesizing the pyridionones are also described.

专利号:US-2010063301-A1
优先权日:2006-03-15
标题 :Synthesis of thrombopoietin activity modulating compounds
发明人：PHILLIPS DEAN
权利人:LIGAND PHARM INC
摘要:Disclosed herein are various methods for synthesizing compounds that modulate thrombopoietin activity. Also disclosed are intermediates useful for the preparation of these compounds.

专利号:US-7732605-B2
优先权日:2005-03-29
标题 :Synthesis of diketopiperazines
发明人：HAYASHI YOSHIO
权利人:NEREUS PHARMACEUTICALS INC
摘要:Disclosed herein are methods for synthesizing diketopiperazines with enantiomeric excess by inducing cyclization of an α-keto acid with an acid catalyst.

专利号:US-10995078-B2
优先权日:2013-03-13
标 题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:US-2006235226-A1
优先权日:2005-03-29
标 题:Synthesis of diketopiperazines