CAS: 43076-59-1; 4-Chloro-1-(Thiophen-2-yl)Butan-1-One

该化合物是一种专门的七环化合物,其特点是氯代代硫苯环,加上丁优优生酮,这种结构具有适合有机合成应用的再活性,特别是作为制药和农用化学中间体的活性.该氯组增强了电益特性,促进了核生殖替代反应,而丁优生酮框架为进一步实现功能化提供了多功能性.其定义明确的分子结构确保了复杂的合成途径的一贯性能.该化合物一般在受控制的条件下处理,因为其具有再活性,其纯度对于目标转换的高产量至关重要.对于需要精确分子修改的研究和工业规模应用来说,它适合.

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物理性质

MSDS等安全信息

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上下游产品

thiophene 4-Chlorobutanoyl chloride thiophen-2-yl magnesium bromide N-Methyl-N-methoxy-4-chlorobutanamidecyclopropyl(2-thienyl)methanone 2-(3-bromo-2-thienyl)-2-(2-thienyl)tetrahydrofuran 4-[(2-Hydroxy-ethyl)-methyl-amino]-1-thiophen-2-yl-butan-1-one 1-Methyl-5-[3-(2-thenoyl)propyl]thio-1,2,3,4-tetrazole

合成工艺路线路线简述

    📜Magnesium,2H-Thiophen-2-Ide,Bromide,4-氯丁酰氯置于n-甲基吡咯烷酮体系中,用 甲苯,四氢呋喃 作为反应溶剂,化学反应 4.75H,以89%的收率获得产物4-氯-1-(2-噻吩基)丁酮
    参考文献:Acylation Of Grignard Reagents Mediated By N-Methylpyrrolidone: A Remarkable Selectivity For The Synthesis Of Ketones
    标题:Acylation Of Grignard Reagents Mediated By N-Methylpyrrolidone: A Remarkable Selectivity For The Synthesis Of Ketones
    摘要:本文介绍了一种高效且用户友好的方法,通过简单的酰胺如nmp或dmf辅助,将格氏试剂酰化以选择性地合成酮.这种化学选择性方法能够容忍包括酮,酯,腈等多种功能团.
    DOI:10.1039/c1Ob05780D

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    专利信息


    专利号:US-2012302756-A1
    优先权日:2010-02-19
    标 题 :Process for synthesis of 2-substituted pyrrolidines and piperadines
    发明人：LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
    权利人:LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
    摘要:The present invention provides a highly efficient, versatile one-step process for asymmetric synthesis of either diastereomer of 2-substituted pyrrolidines from a single starting material with excellent yields and high diastereoselectivety. Also provided is a method for the asymmetric synthesis of both diastereomers of 2-substituted piperidines with good yields and excellent diastereoselectivety. Diasteroselectivity is controlled effectively by choice of reducing agent.

    专利号:WO-2011103263-A2
    优先权日:2010-02-19
    标题:Process for synthesis of 2-substituted pyrrolidines and piperadines

    专利号:EP-2536687-A2
    优先权日:2010-02-19
    标 题 :Process for synthesis of 2-substituted pyrrolidines and piperadines

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    合成参考文献

    合成方法参考DOI号:10.1039/c1ob05780d
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