CAS: 42521-82-4; 1,1'-Disulfanediylbis(Naphthalen-2-Ol)

该化合物是一个有机化合物,其结构特征是两个环球体,由二硫双连接连接连接,具有两种环球体.该化合物具有典型的苯丙化合物特性,包括由于存在氢氧基组而具有作为抗氧化剂的能力.它溶于有机溶剂中,在水中可能表现出有限的溶解性.二硫双联系具有独特的再活动性,允许它参与各种化学反应,包括再毒过程.此外,1,1欧元-二硫双[2-纳phthalenol]可以形成金属离子复合体,这可以提高其在催化或协调化学中作为离子的用途的效用.其潜在应用范围扩大到材料科学和生物化学化学学等领域,可以用作试剂或稳定剂.在处理和储存任何化学物质时,应参考安全数据,以确保采取适当的预防措施.

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欧盟法规

ECHA物质C&L通报

上下游产品

β-naphthol methanol -1,3-oxathiol-2-onenaphth1,2-d-1,3-oxathiol-2-one chloroform 2-methoxynaphthalen-1-yl disulfide 1,1'-bi-2-naphthol 1,1'-thiobis(2-naphthol) 2-methoxy-1-picrylmercapto-naphthalene

合成工艺路线路线简述

    📜1-氯-2-萘酚置于sodium Disulfide,乙醇,铜体系中,化学反应生成 二(2-羟基-1-萘基)二硫醚
    参考文献:Tsukamoto Et Al.,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1953,Vol. 73,P. 1083
    标题:Tsukamoto Et Al.,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1953,Vol. 73,P. 1083

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    专利信息


    专利号:US-11584724-B2
    优先权日:2018-04-23
    标 题:Process for synthesis of a phenoxy diaminopyrimidine compound
    发明人:MALONEY KEVIN M; BASU KALLOL; DI MASO MICHAEL JAMES; HUMPHREY GUY R; LEE ALFRED Y; PENG FENG; REN HONG; ZHANG SIWEI
    权利人:MERCK SHARP & DOHME; WERTHENSTEIN BIOPHARMA GMBH; MERCK SHARP & DOHME LLC
    摘要:Disclosed herein is a novel process for preparing Compound A free base, 5-((2,4-diaminopyrimidin-5-yl)oxy)-4-iso-propyl-2-methoxybenzenesulfonamide, and a citrate salt of Compound A with simplified chemistry and a high overall yield: Compound A. In one embodiment, the overall yield from the starting material 2-isopropylphenol to Compound A citrate salt is greater than 50%. In another embodiment, the overall yield is greater than 60%. Also disclosed herein are novel salts and solvates of Compound A.

    专利号:WO-2022045540-A1
    优先权日:2020-08-28
    标题:Composition for improving muscle strength, alleviating muscle atrophy, or alleviating aging-induced sarcopenia by using ishige okamurae extract or compound isolated therefrom
    发明人:JEON YOU JIN; RYU BO MI
    权利人:JEJU NATIONAL UNIV INDUSTRY ACADEMIC COOPERATION FOUNDATION
    摘要:Disclosed in the present invention is a composition for improving muscle strength or alleviating muscle atrophy by using, in experiments on animal with muscle atrophy, modelsan Ishige okamurae extract or Ishophloroglucin A for alleviating hypotonia or muscle atrophy, promoting the expression of muscle protein synthesis-related factors Akt and PI3K or muscle growth-related factors TRPV4 and A1R, and inhibiting the expression of muscle protein synthesis inhibiting factors Myostatin and Sirt1 or muscle protein degradation-related factors MuRF1 and Atrogin1.

    专利号:US-2017335204-A1
    优先权日:2016-05-19
    标 题 :Heavy amines as hydrogen sulfide and mercaptan scavengers
    发明人:EKOUE-KOVI KEKELI; JONES IAN MICHAEL
    权利人:ECOLAB USA INC
    摘要:The present invention generally relates to compositions and methods for scavenging hydrogen sulfide and/or mercaptans from fluids. More particularly, the invention relates to the use of compositions comprising a surfactant and the reaction product between a polyamine and a formaldehyde as a hydrogen sulfide or a mercaptan scavenger for hydrocarbon-containing fluids, particularly for natural gas, crude oil, field oil, fuel oil, naphtha, gasoline, kerosene, diesel, slurry oil, gas oil, resid, refinery gas, coal gas, tar, asphalt, coke gas, ammonia synthesis gas, gas from an industrial gas stream, or a sulfurization plant.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Ji X, Zhang W, Zhang L, Zhang L, Zhang Y, Tang P. Inhibition of p21-activated kinase 1 by IPA-3 attenuates secondary injury after traumatic brain injury in mice. Brain Res. 2014 Oct 17;1585:13-22. doi: 10.1016/j.brainres.2014.08.026. Epub 2014 Aug 20. doi: 10.1371/journal.pone.0092560. eCollection 2014.
    3: Wong LL, Lam IP, Wong TY, Lai WL, Liu HF, Yeung LL, Ching YP. IPA-3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF-κB activation. PLoS One. 2013 Jul 19;8(7):e68843. doi: 10.1371/journal.pone.0068843. Print 2013.

    合成参考文献


    参考文献:10.1371/journal.pone.0218897
    摘要:Miller TW, Amason JD, Garcin ED, Lamy L, Dranchak PK, Macarthur R, Braisted J, Rubin JS, Burgess TL, Farrell CL, Roberts DD, Inglese J. Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. PLoS ONE. 2019 Jul 05;14(7):e0218897. doi: 10.1371/journal.pone.0218897.
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