📜1-氯-2-萘酚置于sodium Disulfide,乙醇,铜体系中,化学反应生成 二(2-羟基-1-萘基)二硫醚 参考文献:Tsukamoto Et Al.,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1953,Vol. 73,P. 1083 标题:Tsukamoto Et Al.,Yakugaku Zasshi/journal Of The Pharmaceutical Society Of Japan,1953,Vol. 73,P. 1083
专利号:US-11584724-B2 优先权日:2018-04-23 标 题:Process for synthesis of a phenoxy diaminopyrimidine compound 发明人:MALONEY KEVIN M; BASU KALLOL; DI MASO MICHAEL JAMES; HUMPHREY GUY R; LEE ALFRED Y; PENG FENG; REN HONG; ZHANG SIWEI 权利人:MERCK SHARP & DOHME; WERTHENSTEIN BIOPHARMA GMBH; MERCK SHARP & DOHME LLC 摘要:Disclosed herein is a novel process for preparing Compound A free base, 5-((2,4-diaminopyrimidin-5-yl)oxy)-4-iso-propyl-2-methoxybenzenesulfonamide, and a citrate salt of Compound A with simplified chemistry and a high overall yield: Compound A. In one embodiment, the overall yield from the starting material 2-isopropylphenol to Compound A citrate salt is greater than 50%. In another embodiment, the overall yield is greater than 60%. Also disclosed herein are novel salts and solvates of Compound A.
专利号:WO-2022045540-A1 优先权日:2020-08-28 标题:Composition for improving muscle strength, alleviating muscle atrophy, or alleviating aging-induced sarcopenia by using ishige okamurae extract or compound isolated therefrom 发明人:JEON YOU JIN; RYU BO MI 权利人:JEJU NATIONAL UNIV INDUSTRY ACADEMIC COOPERATION FOUNDATION 摘要:Disclosed in the present invention is a composition for improving muscle strength or alleviating muscle atrophy by using, in experiments on animal with muscle atrophy, modelsan Ishige okamurae extract or Ishophloroglucin A for alleviating hypotonia or muscle atrophy, promoting the expression of muscle protein synthesis-related factors Akt and PI3K or muscle growth-related factors TRPV4 and A1R, and inhibiting the expression of muscle protein synthesis inhibiting factors Myostatin and Sirt1 or muscle protein degradation-related factors MuRF1 and Atrogin1.
专利号:US-2017335204-A1 优先权日:2016-05-19 标 题 :Heavy amines as hydrogen sulfide and mercaptan scavengers 发明人:EKOUE-KOVI KEKELI; JONES IAN MICHAEL 权利人:ECOLAB USA INC 摘要:The present invention generally relates to compositions and methods for scavenging hydrogen sulfide and/or mercaptans from fluids. More particularly, the invention relates to the use of compositions comprising a surfactant and the reaction product between a polyamine and a formaldehyde as a hydrogen sulfide or a mercaptan scavenger for hydrocarbon-containing fluids, particularly for natural gas, crude oil, field oil, fuel oil, naphtha, gasoline, kerosene, diesel, slurry oil, gas oil, resid, refinery gas, coal gas, tar, asphalt, coke gas, ammonia synthesis gas, gas from an industrial gas stream, or a sulfurization plant.
1: Ji X, Zhang W, Zhang L, Zhang L, Zhang Y, Tang P. Inhibition of p21-activated kinase 1 by IPA-3 attenuates secondary injury after traumatic brain injury in mice. Brain Res. 2014 Oct 17;1585:13-22. doi: 10.1016/j.brainres.2014.08.026. Epub 2014 Aug 20. doi: 10.1371/journal.pone.0092560. eCollection 2014. 3: Wong LL, Lam IP, Wong TY, Lai WL, Liu HF, Yeung LL, Ching YP. IPA-3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF-κB activation. PLoS One. 2013 Jul 19;8(7):e68843. doi: 10.1371/journal.pone.0068843. Print 2013.
合成参考文献
参考文献:10.1371/journal.pone.0218897 摘要:Miller TW, Amason JD, Garcin ED, Lamy L, Dranchak PK, Macarthur R, Braisted J, Rubin JS, Burgess TL, Farrell CL, Roberts DD, Inglese J. Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. PLoS ONE. 2019 Jul 05;14(7):e0218897. doi: 10.1371/journal.pone.0218897.