CAS: 42288-26-6; 2-((4-Cyanophenyl)Amino)Acetic Acid

相似化合物

5698-54-4 91192-27-7 103-01-5

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CAS号79-08-3 溴乙酸 | CAS号873-74-5 对氨基苯腈 | CAS号79-11-8 氯乙酸 | CAS号3926-62-3 氯乙酸钠 | CAS号144656-11-1 (4-cyanophenyla... | CAS号872728-81-9 甲磺酸达比加群酯 | CAS号211915-06-9 达比加群酯 | CAS号211915-84-3 3-[[[2-[[(4-氰基苯... | CAS号851680-14-3 2-[4-(methanesu...

N-(4-Cyano-Phenyl)-Glycine-Tert-Butylester置于苯甲醚,三氟乙酸体系中,化学反应生成 N-(4-氰基苯基)甘氨酸
参考文献:Platelet Glycoprotein Iib-iiia Receptor (Gpiib-iiia) Antagonists Derived From Amidinoindoles
标题:Platelet Glycoprotein Iib-iiia Receptor (Gpiib-iiia) Antagonists Derived From Amidinoindoles
摘要:A Series Of Substituted Amidinoindoles Have Been Prepared As Mimics Of The Rgd Sequence And Were Studied As Antagonists Of The Platelet Glycoprotein Iib-Iiia Receptor (Gpiib-Iiia). The Agents Were Potent And Selective Antagonists Of Gpiib-Iiia. Compared To Their Acyclic Counterparts,The Amidinoindole Series Bound With 10-To 20-Fold Greater Affinity,Indicating The Advantages Of Added Conformational Restriction And/or Hydrophobicity In The Basic Region Of Rgd Mimics.
DOI:10.1016/0960-894X(95)00563-9

专利信息

专利号:US-9533971-B2
优先权日:2012-10-29
标 题 :Process for the synthesis of dabigatran and its intermediates
发明人：PULLAGURLA MANIK REDDY; RANGISETTY JAGADEESH BABU; NANDAKUMAR MECHERIL VALSAN
权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD; BIOPHORE INDIA PHARMACEUTICALS PVT LTD
摘要:The present invention describes an improved process for the preparation of Dabigatran Etexilate (Formula-VII) or it's pharmaceutically acceptable salt for the treatment of thrombosis, cardiovascular diseases etc. and intermediates involved in the synthesis.

专利号:US-10077251-B2
优先权日:2012-10-29
标题:Process for the synthesis of Dabigatran Etexilate and its intermediates
发明人：PULLAGURLA MANIK REDDY; RANGISETTY JAGADEESH BABU; NANDAKUMAR MECHERIL VALSAN
权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD
摘要:The present invention describes an improved process for the preparation of Dabigatran Etexilate (Formula-VII) or it's pharmaceutically acceptable salt for the treatment of thrombosis, cardiovascular diseases etc. and intermediates involved in the synthesis.

专利号:US-9365544-B2
优先权日:2012-07-16
标题 :Process for the preparation of intermediates for the synthesis of Dabigatran Etexilate, and crystalline forms of said intermediates
发明人：HERNÀNDEZ GALLEGO SANTOS; MARQUILLAS OLONDRIZ FRANCISCO; POMARES MARCO MARTA
权利人:INTERQUIM SA
摘要:The present invention relates to new processes for the preparation of synthesis intermediate products useful in the preparation of Dabigatran Etexilate on an industrial scale. The invention also relates to new crystalline forms of intermediate products thus obtained.

专利号:US-9273030-B2
优先权日:2012-04-02
标题 :Process for the preparation of benzimidazole derivatives and salts thereof
发明人：THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; RAGHURAM SURAPARAJU
权利人:MSN LAB PRIVATE LTD
摘要:Provided are novel salts of benzimidazole derivatives, preferably salts of benzimidazole derivatives which are useful intermediates in the synthesis of pure 1-methyl-2-[N-[4-(N-n-hexyloxycarbonylamidino)phenyl]aminomethyl]benzimidazol-5-yl-carboxylicacid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide and its salts.

专利号:US-9688657-B2
优先权日:2013-03-25
标题:Synthesis of dabigatran
发明人：PATKAR LAXMIKANT NARHARI; MONDKAR HARISH KASHINATH; AROTE NITIN DNYANESHWAR; PATIL SACHIN SHIVAJI; JADHAV TANAJI SHAMRAO; HAGAVANE NITIN NIVRUTTI; BHOPALKAR RAJESH GANPAT
权利人:USV PRIVATE LTD
摘要:The present invention relates to a process for preparation of Dabigatran etexilate or pharmaceutically acceptable salt thereof. The present invention relates to novel compounds, in particular Ethyl-3-{[(2-formyl-1-methyl-1H-benzimidazole-5-yl)carbonyl]-(2-pyridinyl) amino}propanoate and Ethyl-3-{[(2-dichloromethyl-1-methyl-1H-benzimidazole-5-yl)carbonyl]-(2-pyridinyl)amino}propanoate and process for preparation thereof. The present invention further relates to the use of these novel compounds in the preparation of Dabigatran etexilate or pharmaceutically acceptable salt thereof.

专利号:US-2015203470-A1
优先权日:2012-07-16
标 题 :Process for the preparation of intermediates for the synthesis of dabigatran etexilate, and crystalline forms of said intermediates