CAS: 3863-59-0; Hydrocortisone 21-Phosphate

📜11β,17α-Dihydroxy-21-Iodopregn-4-Ene-3,20-Dione置于silver Orthophosphate,磷酸体系中,化学反应生成 [2-[(11S,17R)-11,17-二羟基-10,13-二甲基-3-氧代-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊二烯并[a]菲-17-基]-2-氧代乙基]磷酸二氢酯
参考文献:Poos Et Al.,Chemistry And Industry,1958,P. 1260
标题:Poos Et Al.,Chemistry And Industry,1958,P. 1260

专利信息

专利号:WO-9925385-A1
优先权日:1997-11-17
标 题:A method of increasing nucleic acid synthesis with ultrasound
发明人：UNGER EVAN C; MCCREERY THOMAS; SADEWASSER DAVID
权利人:IMARX PHARMACEUTICAL CORP
摘要:The present invention is directed to a method of increasing nucleic acid synthesis in a cell comprising administering to the cell a therapeutically effective amount of ultrasound for a therapeutically effective time such that said administration of said ultrasound results in said increased nucleic acid synthesis. The nucleic acid sequence may comprise an endogenous sequence or an exogenous sequence.

专利号:WO-9709067-A1
优先权日:1995-09-05
标 题 :Combination of 5-lipoxygenase and leukotriene synthesis inhibitors with glucocorticosteroids
发明人：BURCHARDT ELMAR-REINHOLD; MUELLER-PEDDINGHAUS REINER
权利人:BAYER AG; BURCHARDT ELMAR REINHOLD; MUELLER PEDDINGHAUS REINER
摘要:The combination is disclosed of 5-lipoxygenase inhibitors as direct action lipoxygenase inhibitors (LOI) or of leukotriene synthesis inhibitors (LSI) with glucocorticosteroids (GCS). This combination is suitable for treating and preventing various acute and chronic inflammatory processes, in particular of the respiratory tract, and may therefore be used as a medicament, in particular for treating asthma.

专利号:US-5762918-A
优先权日:1992-03-23
标题:Methods of using steroid-polyanionic polymer-based conjugated targeted to vascular endothelial cells
发明人：THORPE PHILIP E
权利人:UNIV TEXAS
摘要:This invention discloses new targeted conjugates for the delivery of a compound, and particularly, a steroid, to vascular endothelial cells. The conjugates comprise two components, preferably linked by a selectively-hydrolyzable bond, such as an acid-labile bond or enzyme-sensitive bond. The first component, a polyanionic polymer, and preferably, a polysulphated polymer such as a heparin-derivative, specifically directs the conjugate to vascular endothelial cells. The second component is a selected agent, such as a steroid, which exerts a specific effect on the target cell following its release. In particular, the present invention provides novel conjugated angiogenesis inhibitors, for use in the treatment of pathogenic conditions including cancer, arthritis, and diabetic blindness. An inhibitor comprising a heparin derivative and the anti-angiogenic steroid, cortisol, is herein shown to be markedly acid-labile, to suppress DNA synthesis and cell migration in human umbilical vein endothelial cells, to retard or abolish (depending pending on the route of injection) the vascularization of sponges in vivo and to retard lung tumor growth in mice by 65%. No adverse effects of the conjugate were detected, and equivalent treatments with a mixture of heparin plus cortisol were significantly less effective in all cases.

专利号:US-9315799-B2
优先权日:2011-05-10
标题:Process for preparing phosphate compound bearing isotope
发明人：HAMASAKI TOMOHIRO; OHGI TADAAKI
权利人:HAMASAKI TOMOHIRO; OHGI TADAAKI; BONAC CORP
摘要:The present invention provides a process for preparing an isotope-containing phosphate compound easily. The process for preparing an isotope-containing phosphate compound according to the present invention includes the step of: oxidizing a trivalent phosphorus compound with an oxidizing agent containing an isotope to synthesize a pentavalent phosphate compound to which the isotope has been introduced. The present invention preferably is applied to the synthesis of nucleic acids such as DNA and RNA, for example. The isotope preferably is a stable isotope. The oxidizing agent preferably is H 2 18 O, 3H-1,2-benzodithiol 3-one 1,1-dioxide having 34 S, or a diisopropylethylamine-borane complex having 10 B, for example.

专利号:KR-20160017105-A
优先权日:2008-01-15
标题:Synthesis of resorcylic acid lactones useful as therapeutic agents

专利号:KR-20110003468-A
优先权日:2008-01-15
标题:Synthesis of resorcylic acid lactones useful as therapeutic agents