CAS: 35897-92-8; Methyl (2S,4S,E)-3-Ethylidene-4-(2-(4-Hydroxyphenethoxy)-2-Oxoethyl)-2-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-3,4-Dihydro-2H-Pyran-5-Carboxylate

上下游产品

CAS号2280-44-6 D-glucopyranose | CAS号501-94-0 对羟基苯乙醇

📜(2S,3S,4R,5S,6R)-2-(Acetoxymethyl)-6-(((E)-3-Ethylidene-4-(2-(4-Hydroxyphenethoxy)-2-Oxoethyl)-5-(Methoxycarbonyl)-3,4-Dihydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-3,4,5-Triyl Triacetate置于二乙胺体系中,用 甲醇 用作溶剂,化学反应 6.0H,以71%的收率获得女贞甙
参考文献:橄榄苦苷的新半合成类似物在体外和体内显示出改善的抗癌活性
标题:橄榄苦苷的新半合成类似物在体外和体内显示出改善的抗癌活性
摘要:橄榄苦苷是存在于橄榄果实和叶子中的一种糖基化的类花生油.由于橄榄苦苷具有广泛的生物学活性,包括抗癌特性,因此在过去的20年中受到了科学的关注.富含橄榄苦苷的橄榄叶提取物对一系列人类癌细胞系的有希望的抗增殖活性,促使我们着手合成橄榄苦苷的51个类似物.在对雌激素受体阴性乳腺癌细胞株skbr3进行初步筛选后,显示7种类似物显示出明显的细胞毒性,并进一步针对6种其他实体肿瘤衍生和白血病细胞株进行了测试.选择具有最有前途的抗肿瘤活性的类似物(24)进行更详细的研究.24在接近其最大抑制浓度一半的浓度下进行测试时,对健康献血者的外周血单核细胞无毒.在荷黑素瘤小鼠体内给予24只可导致肿瘤大小以剂量依赖性方式减少,并诱导抗黑素瘤反应性免疫反应.我们的结果表明,从橄榄苦苷的初始结构中出现的类似物24代表了有希望的进一步优化的先导结构.
Doi:10.1016/j.Ejmech.2017.05.029

专利信息

专利号:US-12342841-B2
优先权日:2020-09-28
标题:Compositions for improving low testosterone levels
发明人：AYYADURAI V A SHIVA; DEONIKAR PRABHAKAR
权利人:CYTOSOLVE INC
摘要:The present disclosure is related to dietary supplements. In some aspects, this disclosure relates to compositions that can include, one or more agents that can increase the synthesis of testosterone, decrease the degradation of testosterone, and/or decrease the oxidative stress. In some embodiments, an agent of the composition includes: a mineral, a carboxylic acid, a flavone, a flavan, a terpinoid, an amino acid, a benzopyran; and a glycoside, and a combination thereof.

专利号:WO-2018162769-A3
优先权日:2017-03-10
标 题 :Use of dmso for the synthesis of oleacein and oleocanthal

专利号:US-10702550-B1
优先权日:2019-09-10
标 题:Synthesis of olive leaf extract silver nanoparticles
发明人：ALHAJRI HASSNA MOHAMMED; AL-QAHTANI WEDAD SAEED; AL TERARY SEHAM SOLIMAN; ALRFAEI BAHAUDDEEN M
权利人:UNIV KING SAUD
摘要:The olive leaf extract silver nanoparticles may be synthesized by extracting olive leaves and using the extract to synthesize AgNPs. Olive leaves may be washed, dried, and ground to a powder. The olive leaf powder may be mixed with a first solvent to form a first olive leaf extract. The first olive leaf extract may then be separated and/or concentrated by centrifugation and filtration to form a filtrate. The filtrate may be evaporated to form a residue. The residue may then be resuspended in ethanol to form a second olive leaf extract. The second olive leaf extract may be mixed with AgNO 3 to form a mixture including the AgNPs.