CAS: 34830-11-0; Europium D-3-Trifluoroacetylcamphorate

专利信息

专利号:US-4314066-A
优先权日:1976-11-08
标题 :Synthesis of tetramisole, levamisole and their derivatives
发明人：RAGHU SIVARAMAN; HOFFMANN ARTHUR K; SINGH BALWANT
权利人:AMERICAN CYANAMID CO
摘要:A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives, and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of the anthelmintic levamisole, (-)-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives through conventional resolution procedures. The new process also permits the direct manufacture of optically active 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidone and their 3-acylated derivatives, optically active 1-(2-alkoxyethyl)-4-phenylimidazolidine-2-thiones, and levamisole, the levorotatory isomer of tetramisole, using catalytic amounts of a chiral reducing agent, with the elimination of conventional resolution procedures.

专利号:US-4204997-A
优先权日:1979-03-19
标题 :Asymmetric amination of 1,3-dienes
发明人：HOBBS CHARLES F; MCMACKINS DUDLEY E
权利人:MONSANTO CO
摘要:A process for the asymmetric synthesis of amines which comprises the amination of a conjugated diene having from 4 to about 20 carbon atoms in the presence of a catalyst system comprising a palladium compound and an optically active phosphine ligand containing at least two phosphorus atoms.