CAS: 313-67-7; 8-Methoxy-6-Nitrophenanthro[3,4-D][1,3]Dioxole-5-Carboxylic Acid

上下游产品

CAS号13395-02-3 马兜铃内酰胺I | CAS号35142-05-3 aristolic acid | CAS号3580-56-1 Phenanthro(3,4-... | CAS号1169-60-4 Phenanthro[4,3-... | CAS号85814-30-8 Benzo(f)-1,3-be... | CAS号38965-71-8 马兜铃酸A去甲基代谢产物

📜8-Methoxy-6-Nitronaphtho[2,1-G][1,3]Benzodioxole-5-Carbaldehyde置于sodium Chlorite体系中,用 Aq. Phosphate Buffer,二甲基亚砜 作为反应溶剂,化学反应生成 马兜铃酸
参考文献:马兜铃酸,其主要代谢物和相关化合物的全合成
标题:马兜铃酸,其主要代谢物和相关化合物的全合成
摘要:自希波克拉底时代以来,马兜铃属植物已被推荐用于治疗各种人类疾病.然而,许多物种会产生剧毒的马兜铃酸 (Aas),这些物质既具有肾毒性又具有致癌性.为了进行广泛的生物学研究,主要基于 Suzuki-Miyaura 偶联反应设计了一种合成 Aa 及其主要代谢物的通用方法.成功的关键在于制备一种常见的环-A 前体,即 2-硝基甲基-3-碘-4,5-亚甲基二氧基苯甲醇 (27)的四氢吡喃醚,它是通过氧化醛肟前体26.铃木-宫浦联轴器27与各种苯甲醛 2-硼酸酯的反应伴随着羟醛缩合/消除反应,直接得到所需的菲中间体.苯甲醇的脱保护,然后是两个连续的氧化步骤,得到所需的菲硝基羧酸.该方法用于合成 Aa I-Iv 和其他几种相关化合物,包括在 6 位带有氨基丙氧基的 A I 和 Aa Ii,它们是进一步转化为荧光生物探针所必需的.suzuki-Miyaura 偶联反应进一步成功应用于合成aa I 和
DOI:10.1021/tx500122X

专利信息

专利号:US-10111441-B1
优先权日:2018-04-18
标 题:Synthesis of silver-PMMA nanocomposite film using herbal extract
发明人：AWAD MANAL AHMED GASMELSEED; HENDI AWATIF AHMED; ORTASHI KHALID MUSTAFA OSMAN; SOLIMAN DINA WAFIQ AWAD
权利人:UNIV KING SAUD
摘要:The synthesis of a silver-PMMA nanocomposite film using herbal extract includes mixing an aqueous extract of Aristolochia bracteolate buds with an aqueous solution of silver nitrate, thereby reducing the silver ions to silver metal nanoparticles. A solution of the silver nanoparticles is added to a solution of PMMA [poly (methyl methacrylate)] in N′N-dimethylformamide (DMF) with stirring at 80° C. A brown solution of silver colloids develops, which is cast in a glass plate and the DMF is evaporated at room temperature, leaving a silver-PMMA nanocomposite film. Testing on water shows the silver-PMMA nanocomposite film prevents or inhibits growth of microbes, suggesting use as an antimicrobial or antibacterial agent, e.g., in water purification. In addition, testing by disc diffusion against E. coli and Bacillus cereus showed zones of inhibition, also suggesting use as an antimicrobial or antibacterial agent.

专利号:WO-2024109736-A1
优先权日:2022-11-21
标题:Compound, pharmaceutical composition containing same, synthesis method therefor and use thereof
发明人：CAO BIN; ZHAO LIYU; TIAN YE; DOU GUOSHENG; LU SIZHU; YANG JUN; XIE DEWEI; CHEN ZHAOQIANG; ZHANG QIHUA; WANG SHAOHUI; CHEN BIN; ZHANG PEIYU
权利人:SHENZHEN ZHONGGE BIOLOGICAL TECH CO LTD
摘要:The present application provides a compound as shown in formula (0), a pharmaceutical composition containing same, a synthesis method therefor and a use thereof. The compound of the present application can significantly reduce the integrated stress response (ISR) of cells and activate the activity of eIF2B, so that the protein in the cells tends to be synthesized normally, providing more possible drugs for ISR pathway-mediated diseases or condition eIF2B-related diseases, and/or diseases related to regulation of the activity or level of eIF2B activity or level, and regulation of the activity or level of the eIF2 pathway or ISR pathway.

专利号:CN-113684221-B
优先权日:2021-09-10
标 题:Application of benzyl isoquinoline alkaloid and derivative thereof in synthesis of gene Ac6OMT

专利号:SA-119400637-B1
优先权日:2018-04-18
标题 :synthesis of a thin layer of polymethyl methacrylate-silver nanocomposite using herbal extract

专利号:SU-1731053-A3
优先权日:1985-08-28
标题 :Method for synthesis of methylenedihydroxyphenanthrene or theirs pharmaceutically compatible salts

专利号:WO-2019076178-A1
优先权日:2017-10-18
标 题:Medical degradable polyurethane with adjustable degradation time and adjustable elongation at break
发明人：ZHANG WENFANG
权利人:COMSCAFFOLDS NANJING MEDICAL DEVICE CO LTD
摘要:The invention provides a medical degradable polyurethane with adjustable degradation time and adjustable elongation at break, a preparation method and application thereof, and can adjust the proportion of each component in the polyurethane synthesis process and select different chain extenders. Control the performance of PU in a wide range, such as PU degradation time, elongation at break, strength, lubricity and hydrophilicity, etc., can choose different properties of medical degradable polyurethane according to the needs of regenerative medicine and medical devices implanted in the body. .