CAS: 264276-42-8; 2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-3-(4-Fluorophenyl)Propanoic Acid

英文名称2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-3-(4-Fluorophenyl)Propanoic Acid
中文名称2-(((((9H-芴-9-基)甲氧基)羰基)氨基)-3-(4-氟苯基)丙酸
IUPAC名称2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-fluorophenyl)propanoic acid
其它别名N-Alpha-(9-Fluorenylmethoxycarbonyl)-Dl-(4-Fluorophenyl)Alanine; N-Alpha-(9-Fluorenylmethoxycarbonyl)-Dl-(P-Fluorophenyl)Alanine; 2-{[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}-3-(4-Fluorophenyl)Propanoic Acid; Dl-Fmoc-4-Fluorophenylalanine; N-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-4-Fluorophenylalanine; (Rs)-Fmoc-2-Amino-3-(4-Fluorophenyl)Propionic Acid; Fmoc-4-Fluoro-Dl-Phenylalanine≥ (Hplc); Fmoc-4-Fluoro-Dl-Phenylalanine
CAS编号264276-42-8
MFCD编号:MFCD00237667
EINECS号:189-212-3
分子式:C24H20FNO4
分子量:405.42
产品CID: 1239570
产品分类有机原料→生命科学→氨基酸及其衍生物→苯丙氨酸及其衍生物

相似结构搜索
InChIKey: IXUMACXMEZBPJG-UHFFFAOYSA-N
InChI=1/C24H20FNO4/c25-16-11-9-15(10-12-16)13-22(23(27)28)26-24(29)30-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-12,21-22H,13-14H2,(H,26,…
计算化学: 氢键受体数3.0氢键供体数2.0可旋转键数6.0

相似化合物

169243-86-1 177966-64-2 18125-46-7

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
警示词Warning(警告)
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
危险等级IRRITANT

欧盟法规

C&L通报

上下游产品

9-芴甲基-N-琥珀酰亚胺基碳酸酯 N-(9H-Fluoren-2-Ylmethoxycarbonyloxy)Succinimide 82911-69-1

合成工艺路线路线简述

Dl-对氟苯丙氨酸,9-芴甲基-N-琥珀酰亚胺基碳酸酯置于sodium Carbonate体系中,用 1,4-二氧六环,水用作溶剂,以76%的收率获得fmoc-Dl-4-氟苯丙氨酸
参考文献:使用staudinger反应固相合成β-内酰胺,通过19 F NMR光谱监测
标题:使用staudinger反应固相合成β-内酰胺,通过19 F NMR光谱监测
摘要:我们报告了使用19 F NMR作为监测固相反应的简单方法.在涉及氟化α-氨基酯,醛和酰氯的多组分反应的情况下,描述了包括保护,偶联,脱保护,缩合,环加成和裂解步骤在内的多步骤序列.
Doi:10.1016/s0040-4020(03)00553-2

海关参考信息

2902600000-乙苯
2905121000-正丙醇
2912110000-甲醛
2912120000-乙醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC

专利号:US-8338565-B2
优先权日:2008-08-20
标题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
发明人：LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.