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L-天冬酰胺置于碳酸氢钠,氯甲酸苄酯体系中,化学反应生成N-苄氧羰基-L-天冬酰胺
参考文献:新催产素合酶
标题:新催产素合酶
摘要:描述了催产素的新合成.使n-Cbo-L-谷氨酰胺基-L-天冬酰胺基-S-苄基-L-半胱氨酰叠氮化物与l-脯氨酰基-L-亮氨酰-甘氨酰胺反应,得到n-Cbo-L-谷氨酰胺基-L-天冬酰胺基-S-苄基-L-半胱氨酰基-L-脯氨酰基-L-亮氨酰-甘氨酰胺.用乙酸中的hbr除去cbo基团后,该六肽与n-Cbo-S-苄基-L-半胱氨酰-L-酪氨酰基-L-异亮氨酰-叠氮基缩合,得到九肽n-Cbo-S-苄基-L杜维格诺和同事已经通过另一途径获得的-半胱氨酰-L-酪氨酰基-L-异亮氨酰-L-谷氨酰胺基-L-天冬酰胺基-S-苄基-L-半胱氨酰-L-脯氨酰基-L-亮氨酰-甘氨酰胺.用液态氨中的钠还原并再氧化,即可获得生物活性物质.
Doi:10.1002/hlca.19550380622

专利信息

专利号:US-2024218014-A1
优先权日:2022-11-21
标 题:Synthesis of a cyclic peptide
发明人：BAUR PIUS BRUNO; CLEATOR EDWARD; DENIAU GILDAS; EISELE FRANK; FLÖGEL OLIVER; HUSTE ANJA; KEHL MARCEL ROMAN; LÖWENECK MARKUS; SILVA ROLANDO RAVELO; VORBERG RAFFAEL
权利人:JANSSEN PHARMACEUTICA NV
摘要:Processes for performing peptide synthesis, particularly for cyclic peptide synthesis are generally described. Reaction intermediates of the peptide synthesis are also described.

专利号:US-5455363-A
优先权日:1991-10-11
标题 :Amino acid derivatives for peptide synthesis
发明人：GOSTELI JACQUES; SAX BEAT; DICK FRITZ; TANNER RUDOLF
摘要:Compounds of formula I are described, I wherein n is equal to one or two, R1 stands for hydrogen or an amino protecting group, R2 represents hydrogen or a carboxyl protecting group and R3 4-methyltriphenylmethyl, 4,4'-dimethyltriphenylmethyl, 4,4',4''-trimethyltriphenylmethyl. Furthermore described are compounds of formula I which are reactive and suitable for coupling reactions and are derived from I with R2=H by activation of the carboxyl group. The compounds mentioned above can be used as starting materials for the synthesis of peptides. They are more suitable than analogous compounds of formula I, wherein R3 represents hydrogen or a carbamoyl protecting group used hitherto.

专利号:US-2003153783-A1
优先权日:1999-06-30
标题:Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
发明人：GIANNESSI FABIO; DELL UOMO NATALINA; TINTI MARIA ORNELLA; DE ANGELIS FRANCESCO
权利人:SIGMA TAU IND FARMACEUTI
摘要:A process is described for the preparation of R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives with the following formula: n n n where Y is as described in the attached description, starting from aspartic acid with the same configuration as the desired compounds. This process is advantageous from the industrial point of view in terms of the type of reactants used, the reduced volumes of solvents and the possibility of avoiding purification of the intermediate products.

专利号:US-6822115-B2
优先权日:1999-06-30
标 题:Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
发明人：GIANNESSI FABIO; DELL UOMO NATALINA; TINTI MARIA ORNELLA; DE ANGELIS FRANCESCO
权利人:SIGMA TAU IND FARMACEUTI
摘要:R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives are prepared using n starting from aspartic acid with the same configuration as the desired compounds. This process is advantageous from the industrial point of view in terms of the type of reactants used, the reduced volumes of solvents and the possibility of avoiding purification of the intermediate products.

专利号:US-6528684-B1
优先权日:1999-06-30
标题 :Synthesis of (R) and (S) -aminocarnitine and their derivatives starting from D- and L-aspartic acid
发明人：GIANNESSI FABIO; DELL UOMO NATALINA; TINTI MARIA ORNELLA; DE ANGELIS FRANCESCO
权利人:SIGMA TAU IND FARMACEUTI
摘要:R or S aminocarnitine and their derivatives with formula (I)where Y is as described in the description, starting with aspartic acid with the same configuration as the aminocarnitine desired. This process has advantage in the type of reactants used, reduced volumes of solvents and the possibility of avoiding purification of intermediate products.

专利号:US-3725380-A
优先权日:1969-04-05
标 题:Method of synthesizing peptides in the presence of a carbodiimide and a 1-hydroxy-benzotriazole
发明人：KONIG W; GEIGER R
权利人:HOECHST AG
摘要:Improved synthesis of peptides by the carbodiimide method in which an amino-protected amino acid or peptide having a reactive carboxy group is condensed with a carboxy-protected amino acid or peptide having a reactive amino group in the presence of a 1hydroxy-benzotriazole or a substituted 1-hydroxy-benzotriazole of the formula AS WELL AS IN THE PRESENCE OF A CARBODIIMIDE SUCH AS DICYCLOHEXYL CARBODIIMIDE.