CAS: 189628-39-5; 3-Fluoro-5-Methylbenzaldehyde

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CAS号202865-83-6 3-溴-5-氟甲苯 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号491862-84-1 3-氟-5-碘甲苯 | CAS号82102-37-2 9-Methylfluoren... | CAS号216976-30-6 3-氟-5-甲基苯甲腈

📜5-氟-3-碘甲苯,9-Methyl-9H-Fluorene-9-Carbonyl Chloride置于dichloro(Cycloocta-1,5-Diene)Palladium (II),N-甲基二环己基胺,Potassium Formate,四丁基碘化铵,Tricyclohexylphosphine Tetrafluoroborate,Bis(Dibenzylideneacetone)-Palladium(0),Tri Tert-Butylphosphoniumtetrafluoroborate体系中,用 乙腈 用作溶剂,化学反应 18.0H,以96%的收率获得3-氟--5-甲基苯甲醛
参考文献:Reductive Carbonylation Of Aryl Halides Employing A Two-Chamber Reactor: A Protocol For The Synthesis Of Aryl Aldehydes Including 13C-And D-Isotope Labeling
标题:Reductive Carbonylation Of Aryl Halides Employing A Two-Chamber Reactor: A Protocol For The Synthesis Of Aryl Aldehydes Including 13C-And D-Isotope Labeling
摘要:A Protocol Has Been Developed For Conducting The Palladium-Catalyzed Reductive Carbonylation Of Aryl Iodides And Bromides Using 9-Methylfluorene-9-Carbonyl Chloride (Cogen) As A Source Of Externally Delivered Carbon Monoxide In A Sealed Two-Chamber System (Coware),And Potassium Formate As The In Situ Hydride Source. The Method Is Tolerant To A Wide Number Of Functional Groups Positioned On The Aromatic Ring,And It Can Be Exploited For The Isotope Labeling Of The Aldehyde Group. Hence,Reductive Carbonylations Run With (13)Cogen Provide A Facile Access To C-13-Labeled Aromatic Aldehydes,Whereas With Dco2K,The Aldehyde Is Specifically Labeled With Deuterium. Two Examples Of Double Isotopic Labeling Are Also Demonstrated. Finally,The Method Was Applied To The Specific Carbon-13 Labeling Of The Beta-Amyloid Binding Compound,Florbetaben.
Doi:10.1021/jo400741T