CAS: 185968-90-5; Z-D-Dapa(Fmoc)-Oh
该化合物是一种受保护的氨酸衍生物,广泛用于peptide合成,其主要结构特征包括N-terminus的Fmoc (9-氟氧基)-碳基)和侧链的Cbz (苯氧基碳基)组,为固相聚(SPS)的选择性脱保提供或全方位保护.这种化合物对于将(R)-2,3-二氨基丙基丙基硫酸残留物引入peptides特别有用,从而能够准确控制立体化学学,双重保护战略提高了合成灵活性,同时最大限度地减少侧反应.其高度纯度和稳定性使其适合于要求药用化学和生物化学研究的应用,因为再生和立体选择性至关重要.该产品通常以HPLC和NMR为特征,以确保批量一致性.
- 英文名称Z-D-Dapa(Fmoc)-Oh
- 中文名称(R)-3-((((9H-氟-9-基)甲氧基)羰基)氨基)-2-(((苄氧基)羰基)氨基)丙酸
- IUPAC名称(R)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-(((benzyloxy)carbonyl)amino)propanoic acid
- 其它别名N-Cbz-N'-Fmoc-D-2,3-二氨基丙酸; Z-D-Dap(Fmoc)-Oh
- CAS编号185968-90-5
- MFCD编号:MFCD02684469
- 分子式:C26H24N2O6分子量:460.49
- 产品CID: 949366
- 产品分类有机原料→分子砌块→手性化合物→手性砌块
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122235-70-5 131570-56-4 142855-80-9物理性质
MSDS等安全信息
上下游产品
CAS号62234-37-1 N(α)-Z-D-2,3-二氨基丙酸 | CAS号82911-69-1 9-芴甲基-N-琥珀酰亚胺碳酸酯 | CAS号28920-43-6 芴甲氧羰酰氯(Fm°C-Cl)合成工艺路线路线简述
📜N(α)-Z-D-2,3-二氨基丙酸,9-芴甲基-N-琥珀酰亚胺基碳酸酯置于碳酸氢钠体系中,用 水,丙酮 用作溶剂,化学反应 3.0H,反应生成N-苄氧羰基-N'-芴甲氧羰基-D-2,3-二氨基丙酸
参考文献:Benzimidazole Compounds That Are Vitronectin Receptor Antagonists
标题:Benzimidazole Compounds That Are Vitronectin Receptor Antagonists
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2906210000-苄醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Total Synthesis Of Quinaldopeptin And Its Analogues作者:Satoshi Ichikawa,Takuya Okamura,Akira Matsuda |发布日期:2013.12.20
摘要:The First Total Synthesis Of Quinaldopeptin (1) Was Accomplished. Our Approach To The Synthesis Of 1 Includes The Solid-Phase Peptide Synthesis Of The Linear Decapeptide 4 Followed By Macrocyclization And Introduction Of The Quinoline Chromophores 2 At A Late Stage Of The Synthesis. As For The Preparation Of 4, A Fragment Coupling Approach Was Applied Considering The C2 Symmetrical Structure Of 1. Chromophore Analogues 22 And 23 And Desmethyl Analogue 27 Were Also Prepared In A Manner Similar To The Synthesis Of 1. Synthetic 1 Exhibits A Strong Cytotoxicity With The Ic50 Value Of 3.2 Nm. On The Other Hand, The Activity Of 23 And 27 Was Largely Reduced.
合成参考文献
合成方法参考DOI号:10.1021/jo402267r
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