CAS: 1849-55-4; 3-Hydroxypicolinaldehyde

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3-羟基-2-羟甲基吡啶盐酸盐置于potassium Hydroxide,Manganese(Iv) Oxide体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 1.0H,以22%的收率获得3-羟基-2-吡啶甲醛
参考文献:用于检测有机磷神经清除剂的hts分析
标题:用于检测有机磷神经清除剂的hts分析
摘要:一种针对清除剂的hts分析的新型前荧光探针能够选择性和有效地裂解有机磷神经毒剂的ps键,从而设计并合成了无毒的膦酸.先前描述的亲荧光探针是基于传统的活性p O芳基键裂解,而我们的方法使用自脱落接头策略,其允许phosphonothioase活性的检测相对于非活化的p 1-8烷基键.此外,我们还开发并优化了高通量筛选分析方法,以选择可以有效水解高毒性v的去污剂(化学或生物化学清除剂).型神经毒剂.在一个小的α-亲核试剂库上进行的初步筛选使我们能够鉴定出一些初步的"命中",其中吡啶醛肟,α-氧代肟,异羟肟酸和活性较低但较原始的a胺肟是最有前途的.通过使用phx作为底物进一步证实了它们的选择性磷酸硫代磷酸酶活性,因此它们为合成更有效的v神经剂清除剂提供了新的见解.
Doi:10.1002/chem.200902986

专利信息

专利号:US-7026339-B2
优先权日:2003-11-07
标题 :Inhibitors of HCV NS5B polymerase
发明人：YANG FAN; ZHANG BO; WICNIENSKI NANCY ANNE; PFEFFERKORN JEFFREY ALLEN; GREENE MEREDITH L; CHEN KE; NUGENT RICHARD A; REDING MATTHEW TODD; KELLY ROBERT CHARLES; MITCHELL MARK A; FUNK LEE A; HEIER III RICHARD FREDERICK; ANDERSON REBECCA MERRY
权利人:YANG FAN; ZHANG BO; WICNIENSKI NANCY ANNE; PFEFFERKORN JEFFREY ALLEN; GREENE MEREDITH L; CHEN KE; NUGENT RICHARD A; REDING MATTHEW TODD; KELLY ROBERT CHARLES; MITCHELL MARK A; FUNK LEE A; HEIER III RICHARD FREDERICK; ANDERSON REBECCA MERRY
摘要:The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present invention provides novel compounds, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment or prevention of HCV infection. The present invention also provides processes and intermediates for the synthesis of these compounds.

专利号:US-4269773-A
优先权日:1976-04-27
标 题:Fused oxazolidine compounds
发明人：MITSURU YOSHIOKA; TERUJI TSUJI; YASUHIRO NISHITANI; WATARU NAGATA
权利人:SHIONOGI & CO
摘要:Compounds represented by the following formula prepared from 6-aminopenicillanic acid are key intermediates in a stereo-specific synthesis of 1-oxadethiacephalosporins, highly active antibiotics: +TR [wherein COA and COB each is carboxy or protected carboxy; COX is carboxy, protected carboxy, or a group of the formula -COCQ=N2 or -COCHQ-Z (in which Q is hydrogen, lower alkyl or aryl; and Z is hydrogen or a nucleophilic group); Hal is halogen; R is lower alkyl or aralkyl; and Y is hydrogen or acyl].

专利号:US-11999755-B1
优先权日:2024-01-05
标题 :Effective anticancer drug candidate of dinuclear palladium (II) bis-dihydrozone malonyl complex
发明人：ADAM MOHAMED SHAKER SAYED; TAHA AMEL MUSA; ALGHANIM ALHANOOF SAAD IBRAHIM
权利人:UNIV KING FAISAL
摘要:A dinuclear palladium (II) bis-dihydrozone malonyl complex, its synthesis, and its use as anti-cancer agents.