专利号:US-2008242861-A1 优先权日:2007-04-02 标题 :Synthesis of amino-protected cyclohexane-1,4-diyldimethanamine and its derivatives 发明人:YEN CHI-FENG; HUANG CHANG-PIN; HU CHENG-KUNG; CHOU MING-CHEN; KING CHI-HSIN RICHARD 权利人:YEN CHI-FENG; HUANG CHANG-PIN; HU CHENG-KUNG; CHOU MING-CHEN; KING CHI-HSIN RICHARD 摘要:This invention relates to methods of preparing the compounds of formula (V): n n n n n n n n n n Each variable in this formula is defined in the specification.
专利号:US-5916899-A 优先权日:1996-10-18 标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries 发明人:KIELY JOHN S; GRIFFITH MICHAEL C 权利人:TREGA BIOSCIENCES INC 摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.
专利号:US-6417195-B1 优先权日:1999-02-22 标题 :Isoquinoline derivatives and isoquinoline combinatorial libraries 发明人:LEBL MICHAL 权利人:LION BIOSCIENCE AG 摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.
专利号:US-5874443-A 优先权日:1995-10-19 标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries 发明人:KIELY JOHN S; GRIFFITH MICHAEL C 权利人:TREGA BIOSCIENCES INC 摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.
专利号:US-9708336-B2 优先权日:2014-01-22 标题 :Metallo-beta-lactamase inhibitors 发明人:MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.
专利号:US-8450529-B2 优先权日:2008-10-02 标 题:Branched polyamines and formulations thereof for use in medical devices 发明人:KAPIAMBA MBIYA 权利人:KAPIAMBA MBIYA; COVIDIEN LP 摘要:The present disclosure provides for the synthesis of branched polyamines. In embodiments, branched polyamines may be formed by reacting a branched polyol with a nitroaryl carboxylic acid to form a nitrobenzoyl ester which, in turn, may then be subjected to a hydrogenating step to form the branched polyamine. The resulting branched polyamine may then be reacted with another hydrogel precursor to form a hydrogel.
参考标题:Metallo-Beta-Lactamase Inhibitors 摘要:The Present Invention Relates To Compounds Of Formula (I) That Are Metallo-β-Lactamase Inhibitors, The Synthesis Of Such Compounds, And The Use Of Such Compounds For Use With β-Lactam Antibiotics For Overcoming Resistance.
合成参考文献
参考文献:10.1007/s11030-012-9361-6 摘要:Felder ER, Badari A, Disingrini T, Mantegani S, Orrenius C, Avanzi N, Isacchi A, Salom B. The generation of purinome-targeted libraries as a means to diversify ATP-mimetic chemical classes for lead finding. Mol Divers. 2012 Feb;16(1):27–51. doi: 10.1007/s11030-012-9361-6.