CAS: 162046-58-4; Boc-4-Amc-Oh

该化合物是一种受保护的氨基酸衍生物,其基脊为环己烷,具有保护的氨基甲基甲基甲基组和碳酸性功能,该化合物在浸泡物合成和药用化学方面特别宝贵,因为它在标准反应条件下具有稳定性,并且具有多功能性构件的作用. Boc组在温性酸条件下提供选择性的去保护,允许有控制的修改.环己烷环可增强符合性硬性,这在设计生物活性分子方面具有优势.其双重功能组可以进一步衍生,从而有利于发展聚苯乙烯和其他专门中间体.

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1197-18-8 27687-14-5 701-54-2

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CAS号24424-99-5 二碳酸二叔丁酯 | CAS号1197-17-7 cis-4-(氨基甲基)环己酸 | CAS号1197-18-8 凝血酸,氨甲环酸 | CAS号123-91-1 1,4-二氧六环

合成工艺路线路线简述

    📜凝血酸 以97的收率获得反-4-(Boc氨甲基)环己烷甲酸
    参考文献:Heterocyclic Compounds
    标题:Heterocyclic Compounds
    摘要:本发明涉及公式如规范所示的杂环化合物.它还涉及使用其中一种杂环化合物治疗炎症性疾病或免疫性疾病,发育或退化性疾病以及组织损伤的方法.

    海关参考信息

    专利信息


    专利号:US-2008242861-A1
    优先权日:2007-04-02
    标题 :Synthesis of amino-protected cyclohexane-1,4-diyldimethanamine and its derivatives
    发明人:YEN CHI-FENG; HUANG CHANG-PIN; HU CHENG-KUNG; CHOU MING-CHEN; KING CHI-HSIN RICHARD
    权利人:YEN CHI-FENG; HUANG CHANG-PIN; HU CHENG-KUNG; CHOU MING-CHEN; KING CHI-HSIN RICHARD
    摘要:This invention relates to methods of preparing the compounds of formula (V): n n n n n n n n n n Each variable in this formula is defined in the specification.

    专利号:US-5916899-A
    优先权日:1996-10-18
    标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
    发明人:KIELY JOHN S; GRIFFITH MICHAEL C
    权利人:TREGA BIOSCIENCES INC
    摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.

    专利号:US-6417195-B1
    优先权日:1999-02-22
    标题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
    发明人:LEBL MICHAL
    权利人:LION BIOSCIENCE AG
    摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.

    专利号:US-5874443-A
    优先权日:1995-10-19
    标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
    发明人:KIELY JOHN S; GRIFFITH MICHAEL C
    权利人:TREGA BIOSCIENCES INC
    摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.

    专利号:US-9708336-B2
    优先权日:2014-01-22
    标题 :Metallo-beta-lactamase inhibitors
    发明人:MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI
    权利人:MERCK SHARP & DOHME
    摘要:The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

    专利号:US-8450529-B2
    优先权日:2008-10-02
    标 题:Branched polyamines and formulations thereof for use in medical devices
    发明人:KAPIAMBA MBIYA
    权利人:KAPIAMBA MBIYA; COVIDIEN LP
    摘要:The present disclosure provides for the synthesis of branched polyamines. In embodiments, branched polyamines may be formed by reacting a branched polyol with a nitroaryl carboxylic acid to form a nitrobenzoyl ester which, in turn, may then be subjected to a hydrogenating step to form the branched polyamine. The resulting branched polyamine may then be reacted with another hydrogel precursor to form a hydrogel.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Metallo-Beta-Lactamase Inhibitors
    摘要:The Present Invention Relates To Compounds Of Formula (I) That Are Metallo-β-Lactamase Inhibitors, The Synthesis Of Such Compounds, And The Use Of Such Compounds For Use With β-Lactam Antibiotics For Overcoming Resistance.

    合成参考文献


    参考文献:10.1007/s11030-012-9361-6
    摘要:Felder ER, Badari A, Disingrini T, Mantegani S, Orrenius C, Avanzi N, Isacchi A, Salom B. The generation of purinome-targeted libraries as a means to diversify ATP-mimetic chemical classes for lead finding. Mol Divers. 2012 Feb;16(1):27–51. doi: 10.1007/s11030-012-9361-6.
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