CAS: 158171-14-3; Fmoc-Ser(Hpo3Bzl)-Oh

相似化合物

175291-56-2 937171-63-6 329223-23-6

上下游产品

-OPacFm°C-Ser-OPac N-Fm°C serine phenacyl ester benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine{(S)-2-(Benzyloxy-hydroxy-phosphoryloxy)-1-[(S)-1-(di-p-tolylmethyl-carbamoyl)-ethylcarbamoyl]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester Fm°C-O-benzyloxy-phosphono-L-serine cyclohexyl amide 71H112N25O21PC71H112N25O21P

苯甲醇置于2,6-二甲基吡啶,Sodium Bromate,水,Sodium Bromide,三氯化磷体系中,用 四氢呋喃 用作溶剂,化学反应 5.4H,反应生成Fmoc-丝氨酸磷酸苄酯
参考文献: Process For Preparing Phosphorylated Amino Acids[fr] Procédé De Préparation D'Acides Aminés Phosphorylés
标题: Process For Preparing Phosphorylated Amino Acids[fr] Procédé De Préparation D'Acides Aminés Phosphorylés
摘要:本发明提供了一种短,安全,廉价,商业可扩展的过程,用于制备式i的磷酸化氨基酸,可在一个反应釜中完成,无需分离任何合成中间体.

专利信息

专利号:US-2020010502-A1
优先权日:2018-07-05
标题 :Synthesis of multiphosphorylated peptides
发明人：FRIEDLER ASSAF; MAMDI SAMARA SIMHA REDDY; HUREVICH MATTAN
权利人:YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD
摘要:The present invention relates to a new approach for the synthesis of multiphosphorylated peptides. Specifically, the present invention provides a process, which enables the synthesis of multiphosphorylated peptides with up to seven phosphorylated Serine (pSer) and Threonine (pThr) residues, including such residues that are close in sequence.

专利号:US-7781488-B2
优先权日:2002-06-10
标 题:Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation
发明人：BOTTI PAOLO; VILLAIN MATTEO; MANGANIELLO SONIA; GAERTNER HUBERT
权利人:AMYLIN PHARMACEUTICALS INC
摘要:The present invention provides a method and compositions for synthesizing an oligopeptide or polypeptide by convergent assembly of a plurality of pairs of oligopeptides in chemical ligation reactions. An important aspect of the present invention is an oligopeptide having a C-terminal disulfide-protected carboxythioester group that can be deprotected to spontaneously generate a free C-terminal thioester moiety. This allows a single precursor to participate in a succession of chemical ligation reactions, thereby making the convergent synthesis approach possible. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins, and improves the efficiency of native chemical ligation reactions, particularly where four or more peptide fragments are used to assemble an oligopeptide, polypeptide or protein product.

专利号:WO-2022187216-A1
优先权日:2021-03-01
标题:Synthesis of gamma peptide nucleic acid monomers and oligomers, and applications therefor

专利号:ES-2340376-T3
优先权日:2002-06-10
标 题 :DISPROTECTION OF SULFUR AFTER EXCISION FOR CONVERGENT SYNTHESIS OF PROTEINS THROUGH CHEMICAL BINDING.

专利号:CN-106478778-A
优先权日:2016-10-24
标 题 :A kind of solid-phase synthesis method of phosphorylated polypeptide