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2-氟吡啶,碘甲烷置于lithium Diisopropyl Amide,碘体系中,用 四氢呋喃,正己烷 用作溶剂,化学反应 6.17H,反应生成2-氟-3-甲基-4-碘吡啶
参考文献: Hydroxymethyl Piperidine Orexin Receptor Antagonists[fr] Antagonistes Des Récepteurs Des Orexines De Type Pipéridine Hydroxyméthylique
标题: Hydroxymethyl Piperidine Orexin Receptor Antagonists[fr] Antagonistes Des Récepteurs Des Orexines De Type Pipéridine Hydroxyméthylique
摘要:本发明涉及羟甲基哌啶类化合物,其为促进睡眠的受体拮抗剂.本发明还涉及所述化合物在潜在的治疗或预防神经系统和精神疾病中的用途,这些疾病涉及促进睡眠的受体.本发明还涉及含有这些化合物的组合物.本发明还涉及利用这些组合物在潜在的预防或治疗涉及促进睡眠的受体的疾病中的用途.

专利信息

专利号:US-5496952-A
优先权日:1995-02-07
标题 :Method of making asymmetric DE ring intermediates for the synthesis of camptothecin and camptothecin analogs
发明人：COMINS DANIEL L
权利人:UNIV NORTH CAROLINA STATE
摘要:The present invention is directed towards new methods of making DE ring intermediates of Formula (III), ##STR1## wherein Y is H or halogen and R is loweralkyl, which in turn are useful in methods of making camptothecin and camptothecin analogs. The present invention also provides new compounds useful in the methods of making compounds of Formula (III).