CAS: 1424-65-3; 4-(Dibenzylamino)-2-Methylbenzaldehyde

该化合物是在par 位置上有一个二苯甲氨基替代物,在与气态功能组相对的正方位上有一个甲基组,该化合物在有机合成中特别宝贵,作为制备药品,农用化学品和特殊化学品的关键中间体.其二苯甲氨基组可增强有机溶液的溶解性,有利于进一步实现功能化,而藻丁丁胺基系则提供凝聚,减少或核分裂性增加反应的再活性.该组提供静态和电子调节,影响随后变异的再生选择性.该化合物一般供应纯度高,确保合成应用的连续性能.

英文名称4-(Dibenzylamino)-2-Methylbenzaldehyde
中文名称N,N-二苄基-4-氨基-2-甲基苯甲醛
IUPAC名称4-(dibenzylamino)-2-methylbenzaldehyde
其它别名4-Dibenzylamino-2-Methylbenzo-Aldehyde; 4-Di-Benzylamino-2-Methyl-Benzaldehyde; Benzaldehyde,4-[bis(Phenylmethyl)Amino]-2-Methyl-; N,N-Dibenzyl-4-Amino-2-Methyl Benzaldehyde; 3-[bis(Phenylmethyl)Amino]-1-Methyl-1-Cyclohexa-2,4-Dienecarboxaldehyde
CAS编号1424-65-3
MFCD编号:MFCD00799406
分子式:C22H21NO分子量:315.42
产品CID: 650410
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: JMVDVHYMDWJOSI-UHFFFAOYSA-N
InChI=1S/C22H21NO/c1-18-14-22(13-12-21(18)17-24)23(15-19-8-4-2-5-9-19)16-20-10-6-3-7-11-20/h2-14,17H,15-16H2,1H3
计算化学: 氢键受体数2.0氢键供体数*可旋转键数6.0

相似化合物

1199-59-3 92-14-8 61594-81-8

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H312-H332
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

上下游产品

N,N-dibenzyl-3-methylbenzenamine N,N-dimethyl-formamide benzyl chloride 1-amino-3-methylbenzene acetamideN-1-methyl-2-(2-methyl-4-acetamidophenyl)ethylacetamide N-[2-(4-Acetylamino-5-bromo-2-methyl-phenyl)-1-methyl-ethyl]-acetamide 4-(2-Amino-propyl)-3-methyl-phenylamine 4-(2-Amino-2-methyl-propyl)-3-methyl-phenylamine

合成工艺路线路线简述

📜3-甲基苯胺置于potassium Carbonate,Potassium Iodide,三氯氧磷体系中,用 N,N-二甲基甲酰胺用作溶剂,化学反应 2.0H,反应生成4-二苄氨基-2-甲基苯甲醛
参考文献:Selective Monoamine Oxidase Inhibitors. 4. 4-Aminophenethylamine Derivatives With Neuron-Selective Action
标题:Selective Monoamine Oxidase Inhibitors. 4. 4-Aminophenethylamine Derivatives With Neuron-Selective Action
摘要:Nine 4-Aminophenethylamine Derivatives Were Synthesized And Tested For Monoamine Oxidase (Mao) Inhibitory Effects With Particular Attention To Their Selectivity For Mao Within Monoaminergic Neurons In The Rat Brain. All Compounds Selectively Inhibited The A Form Of Mao In Vitro. Some Of The Compounds Inhibited The Mao Within The Monoaminergic Neurons At Much Lower Doses Than Those Required For Inhibition Of Mao Within Other Cells In Vivo. The Most Potent Compounds In This Respect Were 4-Amino-2-Fluoro-Alpha-Methylphenethylamine (5) And 4-Amino-2-Chloro-Alpha-Methylphenethylamine (4).
Doi:10.1021/jm00161A020