CAS: 131-48-6; (4S,5R,6R,7S,8R)-5-Acetamido-4,6,7,8,9-Pentahydroxy-2-Oxononanoic Acid

上下游产品

CAS号72-87-7 N-acelyl-D-gluc... | CAS号312-85-6 乳酸钠 | CAS号7512-17-6 N-乙酰-D-氨基葡萄糖 | CAS号57-60-3 pyruvate | CAS号50-99-7 D(+)-无水葡萄糖 | CAS号328-42-7 草乙酸 | CAS号3615-17-6 N-乙酰-D-甘露糖胺 一水合物 | CAS号57-60-3 pyruvate | CAS号127-17-3 丙酮酸 | CAS号56144-08-2 beta-神经氨酸甲酯

在 Sodium Methylate,水体系中,用 甲醇 用作溶剂,化学反应 24.0H,反应生成N-乙酰神经氨酸
参考文献:唾液酸及其衍生物的三步合成.
标题:唾液酸及其衍生物的三步合成.
摘要:
Doi:10.1002/anie.200601555

专利信息

专利号:WO-0142264-A1
优先权日:1999-12-10
标 题 :Method for the synthesis of sialylated oligosaccharide donors
发明人：MEHTA SEEMA; GILBERT MICHEL; WAKARCHUK WARREN W; WHITFIELD DENNIS M
权利人:CA NAT RESEARCH COUNCIL; MEHTA SEEMA; GILBERT MICHEL; WAKARCHUK WARREN W; WHITFIELD DENNIS M
摘要:A method for the synthesis of aryl thioglycosides comprising a sialylated residue of β-D-galactose is disclosed. The method consists of preparing by a chemical synthesis a non-sialylated aryl thioglycoside, and enzymatically sialylating the latter with a sialic acid in the presence of a suitable sialyltransferase. The sialylated aryl thioglycoside is then chemically derivatized by standard procedures, to provide a derivative suitable for use as a donor in chemical syntheses of sialylated oligosaccharides. The derivatized sialylated aryl thioglycosides are prepared in high yields, due to reduced number of chemical and purification steps involved in the process. Derivatized aryl thioglycosides useful as building blocks for the synthesis of biologically active sialylated oligosaccharides are also disclosed.

专利号:US-2022395800-A1
优先权日:2019-11-04
标题:Device for automated synthesis of oligo- and polysaccharides
发明人：SEEBERGER PETER H; DANGLAD FLORES JOSE; LE MAI HOANG KIM; PARDO VARGAS ALONSO; SLETTEN ERIC; SALWICZEK MARIO
权利人:MAX PLANCK GESELLSCHAT ZU RFERDERUNG DER WSS E V; GlycoUniverse GmbH & Co KG&A
摘要:The present invention generally relates to automated synthesis technology, and more particularly, to a device and method for automated synthesis of oligo- and polysaccharides on a solid support. In particular the present invention relates to a device for automated synthesis of oligo- and polysaccharides on a solid support comprising a reaction vessel, a reagent storing component, a reagent delivery system, a cooling device for cooling reaction vessel, and a pre-cooling device for pre-cooling the reagents to be supplied.

专利号:WO-9423054-A1
优先权日:1993-04-05
标 题:Synthesis of tetrasaccharide
发明人：NILSSON KURT
权利人:PROCUR AB; NILSSON KURT
摘要:The present invention relates to a method for synthesis of a tetrasaccharide or a derivative thereof, which includes the initial synthesis with two different glycosidases of two disaccharides, or derivatives thereof, which after modification are used as donor and acceptor in chemical synthesis of the tetrasaccharide or its derivative.

专利号:US-5374541-A
优先权日:1993-05-04
标 题 :Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides
发明人：WONG CHI-HUEY; GAETA FEDERICO C A
权利人:SCRIPPS RESEARCH INST; CYTEL CORP
摘要:A single reaction vessel process for the synthesis of a sialylated galactoside is disclosed. The synthesis utilizes a β-galactosidase to catalyze the reaction of a galactose-containing substrate and an acceptor to form a new galactosyl glycoside that is then sialylated using a cyclic multienzyme synthesis system to form CMP-sialic acid that sialylates the formed galactosyl glycoside in the presence of an α-sialyltransferase. The value of K m /V max for the formed galactosyl glycoside as a substrate for the α-sialyltransferase is less than one-third the K m /V max value for the galactose-containing substrate for that α-sialyltransferase.

专利号:US-9034844-B2
优先权日:2009-04-06
标 题 :6′-sialyllactose salts and process for their synthesis and for the synthesis of other alpha-sialyloligosaccharides
发明人：TAMERLANI GIANCARLO; LOMBARDI ILARIA; BARTALUCCI DEBORA; DANESI ANDREA; SALSINI LIANA; MANONI MARCO; CIPOLLETTI GIOVANNI
权利人:TAMERLANI GIANCARLO; LOMBARDI ILARIA; BARTALUCCI DEBORA; DANESI ANDREA; SALSINI LIANA; MANONI MARCO; CIPOLLETTI GIOVANNI; INALCO SPA
摘要:The present invention relates to a process of synthesis of α-sialyl oligosaccharides and in particular of 6′-sialyllactose and its salts comprising a step of coupling by Koenigs-Knorr reaction under conditions that allow its use on an industrial scale.

专利号:US-2024327447-A1
优先权日:2021-12-20
标题 :Chemical synthesis of cytidine-5'-monophospho-n-glycyl-sialic acid
发明人：JOSEPH SHAJI; BODENMÃœLLER ARTHUR
权利人:89BIO INC
摘要:Aspects of the present disclosure provide methods for the chemical synthesis of cytidine-5′-monophospho-N-glycyl-sialic acid (GSC).