2-Nitrocinnamic Acid置于双(乙腈)氯化钯(II),1,10-菲罗啉,硫酸,甲酸苯酯,三乙胺体系中,用 乙腈 用作溶剂,化学反应 21.0H,反应生成吲哚-2-羧酸甲酯 参考文献:使用甲酸酯作为 Co 替代物通过硝基化合物的还原环化合成吲哚 标题:使用甲酸酯作为 Co 替代物通过硝基化合物的还原环化合成吲哚 摘要:描述了使用烷基和苯基甲酸酯作为 Co 替代物从适当取代的硝基芳烃制备吲哚和其他n-杂环的非常有效,通用和可扩展的方案.使用甲酸苯酯,产物的分离产率通常高于以前使用气态 Co 实现的收率.通过动力学和机理研究阐明了甲酸苯酯的脱羰反应和环化反应的机理. Doi:10.1002/ejoc.202100789
专利号:US-6258323-B1 优先权日:1998-11-16 标题:Apparatus and method used in multiple, simultaneous synthesis of general compounds 发明人:HORMANN ROBERT EUGENE; GILBERT DARYL EUGENE; SIOMA EDWARD MICHAEL 权利人:ROHM & HAAS 摘要:The apparatus and method of the present invention provides for conducting simultaneous multiple synthesis of general compounds, which often takes place under varied uneven conditions requiring heating, cooling, agitation, reagent/solvent additions to the reactor contents at each reaction vessel location, supply and maintenance of inert atmosphere and means to facilitate the reflux of the reactor contents. Thus, it becomes necessary to monitor and control the reaction conditions during the simultaneous multiple synthesis of general compounds. The apparatus allows the user to connect various independently controlling and conveying means to each reaction vessel through multiple ports provided on a stopper mounted on each reaction vessel. The apparatus of the present invention permits user to readily access the reaction vessels without interrupting the reactions occurring in the adjacent reaction vessels. The unique geometry and shape of the stopper allows positioning of multiple ports, while still providing the stopper with a compact size. As a result, a large array of reaction vessels can be accommodated in the device of the present invention without significantly increasing the overall size of the apparatus. Some of the general compounds that can be readily synthesized by the apparatus and the method of the present invention include inorganic compounds as well as organic compounds, such as oligomers, polymers, agricultural chemicals, drugs, peptides and oligonucleotides.
专利号:US-2008267981-A1 优先权日:2004-06-30 标题:Compositions and Methods for Delivery of Antitumor Agents 发明人:JANDA KIM D; WIRSCHING PETER; BOGER DALE L 权利人:SCRIPPS RESEARCH INST 摘要:Methods for treating a neoplastic disease with an antibody-cytotoxin conjugate molecule, methods of synthesizing an antibody-cytotoxin conjugate molecule are provided. Compounds that are useful as antibody-cytotoxin conjugate molecule or useful in the synthesis of these molecules are also provided.
专利号:US-2023095750-A1 优先权日:2019-12-12 标 题:Flow chemistry synthesis of isocyanates 发明人:BURKART MICHAEL D; PHUNG HAI THIEN AN 权利人:UNIV CALIFORNIA 摘要:The disclosure provides, inter alia, safe and environmentally-friendly methods, such as flow chemistry, to synthesize isocyanates, such as methylene diphenyl diisocyanate, toluene diisocyanate, hexamethylene diisocyanate, isophorone diisocyanate, and tetramethylxylene diisocyanate.
专利号:EP-4073032-A1 优先权日:2019-12-12 标 题:Flow chemistry synthesis of isocyanates
专利号:CN-118724753-A 优先权日:2024-06-18 标题:Method for promoting synthesis of hydroxamic acid by using metal salt
专利号:WO-2021119606-A1 优先权日:2019-12-12 标 题 :Flow chemistry synthesis of isocyanates
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 182. 摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 339. 摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 134. 摘要:Harris, P. A., Science of Synthesis Knowledge Updates, (2021) 3, 154. 摘要:Virieux, D.; Ayad, T.; Pirat, J.-L.; Volle, J.-N., Science of Synthesis Knowledge Updates, (2018) 1, 297.