CAS: 1013-22-5; 1-(2,3-Dimethylphenyl)Piperazine

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95356-15-3 1203-64-1 1013-25-8

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CAS号111073-34-8 7-[3-[4-(2,3-di...

📜1-(2,3-Dimethylphenyl)Piperazine Hydrochloride置于sodium Hydroxide体系中,用 水 用作溶剂,化学反应 0.5H,以96%的收率获得1-(2,3-二甲基苯基)哌啶
参考文献:设计,合成和生物学评估结构受限的杂种类似物,其中包含罗匹尼罗部分作为新型强效和选择性多巴胺d3受体配体
标题:设计,合成和生物学评估结构受限的杂种类似物,其中包含罗匹尼罗部分作为新型强效和选择性多巴胺d3受体配体
摘要:设计,合成和评估了两个系列的杂合类似物,作为多巴胺d3受体的一类新的选择性配体.确定目标化合物的结合亲和力(使用放射性配体结合测定法).与比较剂bp897相比,发现化合物2A和2C对d3受体表现出相当大的结合亲和力和选择性,尤其是化合物2H与bp897(正参比)具有相似的效力和更高的d3R配体.因此,它们可以为发现和开发具有出色选择性的高效多巴胺d3受体配体提供有价值的信息.
Doi:10.1111/cbdd.13324

专利信息

专利号:US-2005019747-A1
优先权日:2002-08-07
标 题 :Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
发明人：ANDERSON DANIEL G; LEVENBERG SHULAMIT; LANGER ROBERT S
摘要:A method of screening cell-polymer interactions. The method includes depositing monomers as a plurality of discrete elements on a substrate, causing the deposited monomers to polymerize, thereby creating an array of discrete polymer elements on the substrate, incubating the substrate in a cell-containing culture medium, and characterizing a predetermined cell behavior on each polymer element.

专利号:US-6960601-B2
优先权日:2001-09-24
标题 :Preparation and use of imidazole derivatives for treatment of obesity
发明人：SMITH ROGER A; O'CONNOR STEPHEN J; WIRTZ STEPHAN-NICHOLAS; WONG WAI C; CHOI SOONGYU; KLUENDER HAROLD C E; SU NING; WANG GAN; ACHEBE FURAHI; YING SHIHONG
权利人:BAYER PHARMACEUTICALS CORP
摘要:This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

专利号:US-9951088-B2
优先权日:2012-05-09
标题 :D2 receptor modulators and methods of use thereof in the treatment of diseases and disorders
发明人：JONES PHILIP G; LEW ROBERT; SPEAR KERRY L; XIE LINGHONG
权利人:SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and neurological disorders, including, but not limited to, e.g., psychosis, schizophrenia, depression, movement disorders, and Parkinson's disease.

专利号:CA-2539670-A1
优先权日:2003-09-15
标 题:Nanoliter-scale synthesis of arrayed biomaterials and screening thereof

专利号:WO-2005028619-A2
优先权日:2003-09-15
标题:Nanoliter-scale synthesis of arrayed biomaterials and screening thereof

专利号:US-9555039-B2
优先权日:2011-05-09
标题:Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT)
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; KUNTZ JUDITH D; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; KUNTZ JUDITH D; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: Formula (I)