CAS: 100-11-8; 4-Nitrobenzyl Bromide

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CAS号619-73-8 对硝基苯甲醇 | CAS号631-61-8 乙酸铵 | CAS号558-13-4 四溴化碳 | CAS号555-16-8 对硝基苯甲醛 | CAS号99-99-0 对硝基甲苯 | CAS号619-75-0 Benzene,1-(dibr... | CAS号14856-73-6 (4-Nitrobenzyl)... | CAS号6971-51-3 3-甲氧基苄醇 | CAS号1058649-42-5 4-nitro-1-[(eth... | CAS号105535-09-9 1-but-3-enyl-4-... | CAS号107484-31-1 1-[(4-nitrophen... | CAS号108049-92-9 5-[(4-nitrophen... | CAS号1012-18-6 1-(2-methylprop... | CAS号107108-25-8 2-methyl-4-nitr... | CAS号456-42-8 间氟氯苄 | CAS号555-21-5 4-硝基苯乙腈 | CAS号4403-71-8 4-氨基苄胺 | CAS号142599-44-8 (4-nitrophenyl)... | CAS号14064-58-5 1-methoxy-3-[2-...

4-硝基甲苯置于n-溴代丁二酰亚胺(Nbs)体系中,用 四氯化碳 用作溶剂,化学反应生成对硝基溴化苄
参考文献:碳的均质置换:X.甲苯磺酰碘作为甲苯磺酰基自由基的来源,用于形成烯丙基,苄基,环丙基羰基,螺环丙基环烷基,双环[1.0.3]烷基和双环[1.0.4]烷基-4-有机钴肟的甲苯磺酸酯
标题:碳的均质置换:X.甲苯磺酰碘作为甲苯磺酰基自由基的来源,用于形成烯丙基,苄基,环丙基羰基,螺环丙基环烷基,双环[1.0.3]烷基和双环[1.0.4]烷基-4-有机钴肟的甲苯磺酸酯
摘要:4-甲苯磺酰碘在约40oc下与多种烯基和苄基-钴氧肟类发生热反应,可制得高产率的有机-4-甲苯磺酸酯.烯丙基钴肟主要产生,有时在某些情况下仅产生重排的烯砜.脂环族的3-烯基钴肟化合物产生相应的环丙基-羧甲基砜;环烯基乙基钴肟酯产生螺-1,1-环丙基-环烷基砜;环烷-2-烯基甲基钴肟生成双环[1.0.ñ]烷基砜.螺和双环烷基化合物也与其他自由基前体形成.认为反应通过链机制发生的,其中不定存在或通过底物部分均相形成的钴肟(II)从甲苯磺酰碘中提取碘,生成甲苯磺酰基自由基,该自由基攻击钴肟的有机配体,优选在末端烯烃碳处,从而置换钴肟(II)并得到所观测到的有机产物.
Doi:10.1016/0022-328X(85)87417-9

专利信息

专利号:US-11840544-B2
优先权日:2018-07-02
标 题 :Intermediates in the synthesis of C3-substituted cephalosporins
发明人：MADELA KAROLINA
权利人:NORBROOK LAB LTD
摘要:Disclosed herein are novel and inventive methods for preparing intermediates in the synthesis of C3-substituted cephalosporins. One preferred C3-substituted cephalosporin of clinical interest is Cefovecin. Accordingly, the present invention provides for methods of preparing reactive halogen intermediates for use in the synthesis of C3-substituted cephalosporins, such as Cefovecin. In the case of Cefovecin the reactive intermediates are of the formula:

专利号:US-4427587-A
优先权日:1982-11-10
标 题:Total synthesis of antitumor antibiotics BBM-2040A and BBM-2040B
发明人：KANEKO TAKUSHI; WONG HENRY S L
权利人:BRISTOL MYERS CO
摘要:A new chemical synthesis of the pyrrolobenzodiazepine antibiotics BBM-2040A and B is disclosed. The disclosed total synthesis uses readily available starting materials and provides a useful alternative to the microbiological procedure previously used to prepare these antibiotics.

专利号:US-6951932-B2
优先权日:2001-10-25
标 题:Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines
发明人：MOORMAN ALLAN R
权利人:KING PHARMACEUTICALS RES & DEV
摘要:The invention provides new methods for synthesis of 2-aralkyloxyadenosines and 2-alkoxyadenosines. The invention is particularly useful for synthesis of 2-[2-(4-chlorophenyl)ethoxy]adenosine. Preferred methods of the invention include activating a guanosine compound followed by hydrolysis; alkylating the hydrolyzed compound with subsequent animation to provide a 2-aralkyloxyadenosine or a 2-alkoxyadenosine compound.

专利号:US-9879043-B1
优先权日:2013-06-06
标 题:Synthesis of non-natural cofactor analogs of S-adenosyl-L-methionine using methionine adenosyltransferase
发明人：THORSON JON; HUBER TYLER; ZHANG JIANJUN; Singh Shanteri
权利人:UNIV KENTUCKY RES FOUND
摘要:The present disclosure relates to the synthesis of non-natural analogs of S-adenosyl-L-methionine (SAM) and/or of Se-adenosyl-L-methionine (SeAM) by reacting a methionine analog and adenosine triphosphate (ATP) in the presence of at least one methionine adenosyltransferase (MAT), and to use thereof with downstream SAM and/or SeAM utilizing enzymes. The non-natural analogs of SAM and/or SeAM have the general formula: n nwhere X is S or Se, and R 1 is an alkyl group.

专利号:US-9556140-B2
优先权日:2013-01-26
标 题 :Approach for synthesis of catechins
发明人：DUGAR SUNDEEP; MAHAJAN DINESH; RAI KUMAR SANTOSH; TRIPATHI VINAYAK; PATIL ISHWAR RAKESH
权利人:SPHAERA PHARMA PRIVATE LTD
摘要:A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+ and/or −) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (−)-epicatechin; (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin.

专利号:US-6455680-B1
优先权日:2000-12-21
标 题 :Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
发明人：LUKIN KIRILL A
权利人:ABBOTT LAB
摘要:An efficient deoximation technique for use in synthesis of erythromycin derivatives, involving aryl thioimine intermediates is disclosed. The aryl thioimine intermediates can be utilized in a method for protecting a ketone of a ketone-containing erythromycin derivative as a thioimine; a method for deoximating an oxime-containing erythromycin derivative, or a method for preparing a 6-O-alkyl erythromycin derivative. Presently preferred erythromycin derivatives have a C-9 oxime or a C-9 ketone.